One should never take as much Lysine as you have suggested. I have been taking L-Lysine for 15yrs for herpes and have never heard of such a high dose. Most medical practictioners suggest 500mg daily before food or other aminos and during an outbreak up to 1500mg/day. This has helped me control my outbreaks for a long time. Not one source that I have researched during this time has suggested such a high dose. Overloading of the liver would seem common sense with that dose.