Unlocking Well-being: 5-HTP's Remarkable Health Benefits

| Modified on Jan 10, 2024
5-HTP Side Effects
Posted by Ann (Louisville, KY) on 09/10/2021


I have been taking 5-HTP with Vitamin B6 (50mg) for the past month and have had serious side effects. I would take one dose in the morning with breakfast and one in the evening when I first started, but invariably would miss the second dose as I would forget to take it with my dinner. I then noticed I was having more diarrhea than normal and researched 5-HTP to find that that was a side effect. So I cut back to only taking 50mg every other day. During the early morning hours of Thursday, September 9th, I had a violent tremor outbreak that was happening over my whole body. It lasted between 45 minutes to an hour and only seemed to release when I would cough hard or yell and the reprieve only lasted a minute or so. I took off work on September 9th because I was wasted after this occurrence and slept the whole day. After returning to work today (Friday, September 10th), I again researched 5-HTP to see if there was any link and there was. Quote from draxe.com "There are some potential side effects to be aware of: indigestion and stomach problems; heartburn; nausea; vomiting; fatigue and drowsiness; sexual dysfunction; and muscular spasms and dysfunction." According to other research, these muscular spasms only happen to a select few (I'm one of the lucky ones).

I only researched 5-HTP, because I knew of no other reason why I would be having this type of tremor episode. I am on blood pressure medication and have been for years without having this type of episode before. So I am truly thinking that it has something to do with the 5-HTP. The weird thing is, I was only taking 50mg doses and just recently those were only taken every other day, so I don't think there was that much of an increase of serotonin in my system. Perhaps it's because the Vitamin B6 caused the 5-HTP to be more effective more quickly. I don't really know. I've given my doctor my observations and wait to see what she says. Just wanted to give everyone a heads up on here as I use earthclinic.com any time I am researching for natural supplements.

5-HTP Side Effects
Posted by Denise (Us) on 12/17/2018 50 posts

I can't agree with this more, especially about the treating symptoms instead of looking at possible causes. For the first time in my 66 years, I am looking at my whole food intake, and exercise habits. I've changed a lot already, and honestly, for me it isn't about living longer, it's just about feeling as good as possible, and doing the things I love for as long as I am here.

I am starting to be hooked on healthy, food choices, and if I feel I am not getting enough of some nutrient, I am supplementing with vitamins and minerals. I don't expect to cure every single issue I have, but many of those issues are improving and that is enough for me to stick with this. Love EC, and the people here that share what they've tried, and what they've been successful with. I know we all are unique so I also never expect something to work for me, or at least not at the same dose etc.

Sleep, Depression and Meditation
Posted by Blue Star (Tennessee) on 05/10/2018

Poor sleep really impacts your quality and outlook on life. For years I have had poor sleep due to back pain, inflammation and was never able to go into deep sleep. Every year about January and February I would have acute SAD.

I found 5 HTP and am really impressed at how my life has improved. I take 2 50mg capsules about an hour before I go to bed. I finally go into a deep sleep and I awake in the morning loving life again. I feel refreshed. I feel like 5 HTP has restarted my serotonin and melatonin production. I feel that I don't need to take every night because now I naturally start to get sleepy, but I still do anyway. My depression is much improved.

Several things I noticed taking 5 HTP. Less is better. Start at 50 mg's. Too much will cause vivid dreaming. Sometimes I am aware that my short term memory is impacted. I am observing if 5 HTP makes a learning issue worse or better and how it effects my memory.

I am an energy healer and meditate on a regular basis. Serotonin and melatonin are produced by the pineal gland, the gland of enlightenment. I am finding that my inner experiences and process seem to be highly supported by 5 HTP.

5-HTP Side Effects
Posted by Quercus (Socals) on 05/13/2014

When one reads about studies concerning either the good or bad about a supplement, it would be wise to ascertain who paid for those studies. Also, it is a good idea to look at the number of participants. While there can be a lot good info gleemed off the internet, there are also a lot of information that is untrue, out of context or without full disclosure. Some websites promote the image of being impartial, when they are not.

As with any prescription anti-depressant, it would be wise when taking a new supplement to start out slowly.

5-HTP for Teenagers
Posted by Mama To Many (Tennessee, Usa) on 12/20/2013

Hi Dana,

It is worrisome to see a teen work hard and be tired and have headaches! I have seen this too with my sons.

One thing is that teens do need more sleep for a time during the mid-teen years. I have worried when it appears my teens need more sleep than their younger siblings. Teens often do not get adequate sleep and often get irregular sleep. But between school and social lives etc, it can be hard to get them to sleep enough. Does he have trouble sleeping? Sleepytime tea before bed actually helps a lot for many, if so. I don't know that I would start with 5-HTP, I don't know much about it. But others may have another thought on this.

I agree with Mike that getting him some concentration nutrition is important. Teens are growing and need extra nutrition. Unfortunately, they are often not getting a very good diet, especially if they are consuming fast food, energy drinks, caffeine, etc. In fact, MSG (in fast food or processed food), processed sugar, and energy drinks can all cause headaches and anxiety.

Most of us are iodine deficient. A drop of Lugol's iodine daily, or a kelp tablet (not as much iodine, but still helpful to some.) might be helpful. Low iodine affects energy poorly. Also, daily vitamin C and D and B complex would be good. I did this for my son who is 17 and it did make a noticeable difference.

Sometimes a few simple changes will help. Sometimes it might be more complex. An underlying virus could cause be involved and then I would consider Dave's colloidal silver plan.

Keep us posted on what you try and how it is going. If the first things you try don't work, EC posters will likely have some more ideas for you!

~Mama to Many~

5-HTP for Teenagers
Posted by Mike 62 (Denver, Colorado) on 12/19/2013

Dana: I had what your son has when I was his age, only I was a lot worse. 40 years later I learned that cooked regular food does not have any enzymes, humic acids that activate nutrients, xeronines that activate proteins, sulfur, or trace minerals. Do your son a big favor and feed him raw organic, grassfed, and superfood concentrates, and make home made water kefir. You can watch raw food videos for some great ideas.

5-HTP for Teenagers
Posted by Dana (Sheridan, Wyoming) on 12/19/2013

Would 5-HTP be advisable for my 16 year old son? He seems to be tired a lot, gets frequent headaches, looks to have low energy (except when he is with his friends and has bouts of anxiety. He has a huge homework load from AP classes but handles his homework well. I worry about his headaches and anxiety. Any advice would be appreciated. Thank you.

Posted by Jillery (North Carolina (nc)) on 11/24/2013 88 posts

All this information goes to show how differently we all are and all can react to different supplements. There is not just one cure all for depression. Look at the book Nutrition Power and it discusses the different types of depressions. My holistic psychiatrist suggested I read it. I weaned myself off psych meds about 8 years ago using the TrueHope site and vitamins. I have been off meds but have not been taking supplements or meditating like I should have. I went into a large depression after losing my job (situational depression)-- I found this new psychiatrist and I am taking multi vits, omega 3's, D, aminos along with additional 5HTP and GABA. It seems I am serotonin lacking as the last two supplements got me around the corner. But everyones system is vastly different. Best wishes. I get most of my vitamins on Amazon-- the better brands.

Buy Quality 5-HTP
Posted by Anonymous (Oz, Middle Earth, ) on 07/11/2013

Hello, not insult to anyone but when you get vitamins from Walgreens, Walmart etc. it is not good for your health. Walmart's food is GMO (Genetically Modified=cancer etc. Do your research and look at fillers in vitamins. GMO foods are banned everywhere but in the U.S, why because MONSANTO is here. Do your research. MONSANTO cannot be sued in the U.S. i.e., MONSANTO PROTECTION ACT passed this year. Our organic farmers crops are being poisoned and sterilized by their chemicals. GMO foods and their side affects are lethal. Support your local farmers. Dr. Mercola and Dr. Andrew Lessman are the best vitamins (natural) I've found. Lessman's are even grown in solar powered nurseries etc. Please do your research. <3 and Peace to all of you.

Posted by Neukoln (Edinburgh, Scotland, Uk) on 02/03/2013

I can't find the post, but someone commented that taking a lower dose of 5HTP is more effective. [It may have been on the Depression pages?] I have to agree with this. I had crippling depression, and so I had gradually increased to 300mg/day (3 x 100mg) thinking that I needed the maximum dose - because my depression was almost making me bed-ridden. But that very high dose gave me a weird anxiety, and racing heart, and I took ages to fall asleep. And I got very loose bowels too.

I am now taking 200mg. I break open one of the capsules and have 50mg under the tongue 1/2 hour before breakfast, then 100mg under the tongue 1/2 hour before dinner, and finally 50mg under the tongue 1/2 hour before bed. I feel so much better. My depression has completely gone. I feel happy. I am thinking of reducing the 100mg dinner-time dose to 50mg. But maybe when the Winter has passed.

5-HTP Side Effects
Posted by Charlotte (Honolulu, Hi) on 02/02/2013


hey everyone who wants to try 5-HTP you should research it first... It's the cause of Eosinophilia Myalgia Syndrome (EMS). I thought I was going to try it until I read about this. The side effects among other things are extreme muscle pain, tremors, and it's a life-long condition. It has also killed people.

Posted by Adam (Southern, California) on 09/26/2012

I am a 26 year old male who has suffered from depression and sleeping problems for years. I have been on medication such as Effexor XR, Trazodone, etc. I was also diagnosed with ADD, given a prescription of Adderall XR. Ever since I was a teen I suffered from the issue of getting too much sleep. I always felt tired. Sleeping 10 hours would result in me feeling exhausted upon waking. No amount of sleep could remedy the issue (no matter how little or how much). I enjoyed Adderall because it made me feel "Awake" and able to concentrate on my studies; However, the side-effects were too great. I recently started supplementing 100mg of 5-HTP before bed. I have been waking up in the morning naturally after 6-8 hours of sleep. The beneficial effects of 5-HTP have been a live saver for me. I feel happier, my quality of sleep has improved beyond measure, and I feel rested and refreshed in the morning. I highly recommend this to people suffering from the "too much sleep" problem. There are many who suffer in silence, give this supplement a shot!

5-HTP Side Effects
Posted by Guata (Provo, Ut) on 07/27/2012


I tried 5-HTP, 50 mg. I slept great but woke up with burst blood vessels in my left eye. I tried it a few nights later and the same thing happened: I slept great again but had the burst blood vessels again. I don't dare use it anymore.

5-HTP Side Effects
Posted by Rolf (Los Angeles, Ca, Usa) on 07/25/2012

Interestingly enough, and rather contrary to the popular marketing perspective, much of the research on tryptophan and 5-hydroxytryptophan documents that it isn't particularly beneficial for insomnia and depression.

Worst of all, there are many distressing side effects from the use of (prolonged) tryptophan supplements, such as cancer promotion. I wrote an article on this, "Tryptophan Side Effects: L-Tryptophan Is Far From Harmless", which you can access at http://www.supplements-and-health.com/tryptophan-side-effects.html

Posted by Gail (Branson, Missouri) on 01/20/2012

My husband got the 5-HTP from reading about it in Ray and Terry's info... I can get grouchy, so I took some to see the effect. I took 100mg in the morning and I forgot about it as I was busy that day... Then later in the day when I was doing school work with my kids and my son didn't want to focus and was acting up, which usually upsets me, I felt calm and I noticed it... It was nice... I guess you could say it took the edge off of my irritation?? I had no side effects other than vivid dreams but not bad dreams... I think it depends on your brain chemistry and particular problems.

I know a friend who had severe depression for years who recently cured it with ACV and some slight diet changes, so go figure. My husband tends toward anxiety and he likes what it does for him, but he does not take it every day, more like every other. We have learned over the years often with anxiety/depression you need magnesium and homeopathic meds are often good for this or epsom salt baths.

5-HTP and Zoloft
Posted by Shelby (Wilmington, Ca) on 12/22/2011

Jaime! You should look into meditation and yoga to help with your depression. Sending you lots of love and light :)

5-HTP Tips
Posted by Chicagorock (Chicago, Il) on 03/06/2011

Hi patricia,

you might try neuroassist. it's a mix of htp-5 with other co-factors that you need in balance. they say that htp-5 alone with put your other neurotransmitters out of whack, here is their web site www.neuroassist.com/. my therapist said that her clients are doing much better with neuroassist. hope you feel better, patricia, good luck.

Restores Serotonin Levels
Posted by Christy (Portland, Or) on 09/17/2010

It's fairly common amongst users of psychedelic drugs known to effect serotonin receptors and levels (MDMA, LSD, etc. ) to use 5-HTP to restore serotonin levels. I've found that it noticibly helps myself and have seen it gain a lot of popularity over the last few years. It'd be interested to see legitimate research done.

5-HTP vs L-Tyrptophan
Posted by Peggy (Loveland, Co) on 07/15/2010

My understanding is that 5-HTP is the intermediate biochemical in the body between tryptophan and serotonin. Tryptophan is in some foods like turkey and Brazil nuts, and our bodies turn it into 5-HTP, which is then turned into serotonin. L-tryptophan was the supplement version of tryptophan, but apparently had some unpleasant side effects so it was pulled. www.5-HTP.org has some good info about it. I have had good luck with 100 mg of 5-HTP on an empty stomach about an hour before bedtime. I sleep more restfully and am happier when I wake up. I understand it's good to start with 50 mg and see if that works, and add more if needed. If I run out and don't get more for a few days, I start having more insomnia and sadness within a few days. Also, it took a few days to take effect, but has been well worth it and no side effects.

5-HTP Side Effects
Posted by Sheryn (Milwaukee, Wi) on 04/17/2010

Susan and others...I noticed while researching several options to treat low-level depression, that many caution against using if your depression has a bipolar (manic) component. My guess is that increasing serotonin in that instance leads to the manic activity and irritability (depressed mood manic energy me = one serious crabby-butt, lesson learned with an ill-fated combo of stimulants for attention deficit).

The solution for you may lie in working with other parts of your brain chemistry. Maybe see what folks are recommending for bipolar/cyclothymia.

Posted by Kristina (Beverly, Ma) on 04/03/2010

I'm sorry for the delay in my response - I take the 5htp once a day at about 10:30am. If I took it immediately upon waking, I'd probably take two a day... but taking it at that hour, I only need one.

I usually feel pretty good all by myself in the mornings.

5-HTP and Zoloft
Posted by Kimbies (Omaha, Nebraska) on 03/26/2010

regarding the question of taking 5HTP with Zoloft. As long as you have a window of over 8-10 hours between taking the Zoloft and 5HTP it should not be a problem. Many people successfully are on both just not at the same time in the day as to avoid Seratonin overload.

Posted by Gean (Salina, Ks) on 03/25/2010

Do you take the 5-HTP in the morning, or at night? Thank you.

Posted by Kristina (Beverly, Ma) on 03/25/2010

I used to take an Rx SSRI for seasonal depression and weight loss but after two years, my body decided it didn't want it anymore. I got anxious to the point of paranoia, I binged on sweets, and I lost the will to do much beyond sit in front of my TV/computer.

I weaned off it and discovered 5-htp. When I first began taking it, I took low doses (25 mg or 50mg) a couple times a day. It would work fine for a couple days and then I would have side effects like bone aches, sleepiness (no matter how much sleep I got), anxiety, and constant hunger. I tried taking smaller doses and found it to have no effect. Frustrated, I nearly stopped taking it.

I then found a time-release capsule of 5-htp. There is at least one company that makes it in a 100mg. It works incredibly well. I haven't felt this "normal" in a very long time. I'm awake during the day and I sleep at night, I eat normally and stop eating when I'm no longer hungry, and I'm able to handle stressful situations calmly. I honestly don't feel like I have any side effects.

I am 32 years old and female. The other things I take daily are a 'complete' vitamin, rhodiola rosea 400mg lysine 500mg, glucosamine/condroiton, fish oil, and 1000 mg of vitamin D. I've been taking all of those for years before taking 5-htp.

If you're having trouble with the 'normal' doses of 5-htp, I highly recommend trying the time release version before giving up on it entirely.

5-HTP and Zoloft
Posted by Bee (Anon, Anon) on 03/15/2010

If you do take 5-HTP and Zoloft, there is a chance that your serotonin levels will rise too high. Also, realize that there is a chance of withdrawal as you wean yourself off of Zoloft. I would consult with a medical professional to help you wean off the Zoloft gradually, to ease any withdrawal. I used 5-htp to help wean off Paxil(another SSRI)- I'm at a half dose now, but not trying to reduce it any right now. I had really severe withdrawal so it may be better to give your system a break before starting the 5-htp. At least in my experience weaning off is really hard and it's important to take care of yourself and have the support of someone to help you get through it.

5-HTP and Zoloft
Posted by Jamie (Breese, Il) on 03/13/2010

I have battled with depression since I was a freshman in highschool, im 29 now. I take 150mg of Zoloft everyday. If I wanted to try this 5-HTP would I also have to stop taking the Zoloft or could I take both. The Zoloft does not help with my times of excessive worrying, mood swings, or the feeling of being tired all the time. Any suggestion??

5-HTP Side Effects
Posted by Susan (Hamilton, Ontario, Canada) on 02/13/2010

After hearing the great things about 5-HTP, I gave it a whirl for my anxiety and sleeplessness. I reacted very paradoxically to this supplement, as within two hours I was alert and energetic to the point of hyperactivity, also my mood became very agitated and I was extremely cranky with those that I love. The only good thing was that I got through a mountain of housework in a half day because I just could not stop. The effects carried on into the night and I only was able to sleep for an hour at most. Wanting to give this a really good trial, I carried on for about a week but the effects were the same, I hated the way I was feeling, and I finally gave the tablets away.

5-HTP Tips
Posted by Patricia (Gainesville, FL) on 06/16/2009

My daughter take 5HTP but she takes P-5-P along with it. Does anyone have any info on the P-5-P. After reading some of the side effects some people have had I am a little afraid to take it. I have just started on Tumeric. Had to quit Bill's spray and ACV as it made my throat so sore my voice dropped a few levels. Any one else had this happen?

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