I started taking high doses of Vitamin C to help ward off a cold virus. For the past several weeks I took 5-10 grams of Vitamin C. I noticed my knee pain disappeared. I am a runner/cross country skier who has virtually stopped these activities due to pain in my right knee. For 7 years I have tried glucosamine, calcium, MSM, and NSAIDs. I don't like taking NSAIDS. However, the other remedies did not relieve the pain and inflammation .Therefore, I have been tolerating the pain and have discontinued using NSAIDS. I was very surprised to find that the Vitamin C use correlated with complete pain relief and reduction of inflammation. So I stopped the C for a week and the pain returned. I have resumed the C and the pain is gone again.