I have had chronic pain from fibromyalgia, and bone-on-bone in left knee for 11 years. With the fibro, it used to hurt just to move or try and get out of bed. Excruciating to try and turn over in bed at night, and could barely walk during waking hours. Couldn't straighten up due to hip pain and all. Well, not anymore. Serrapeptase has literally given me a new lease on life. I also take MSM faithfully. No pain at night anymore. Talk about relief!! Immediate relief with the Serrapeptase, especially. Every bone in my body hurt before taking that. I thank God for it! You won't be sorry if you try these. I've recently added ACV and use either honey or Stevia to tame the taste. Makes it pleasant to taste and still does the job. Hope this helps someone. I'll never be without any of these.