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From the Book: Healing Factor Vitamin C Against Disease – by Irwin Stone, Linus Pauling, Albert Szent-Gyorgyi 1972, p. 121-123
Source on-line: https://vitamincfoundation.org/stone/
Source download book: https://welib.org/md5/35609ae8abf6e1dcb1cc701374943358
Now let us turn to allergic manifestations in man and look into hay fever, or pollinosis. In 1942 a paper by Holmes and Alexander (5) appeared and gave the results of tests on twenty-five hay fever patients tested consecutively with 100 milligrams of ascorbic acid per day for the first week, 200 milligrams daily for the second week, and finally, 500 milligrams daily for the third week. In most cases, little or no relief was afforded by the 100 milligrams per day level, but when the higher doses were used on the same subjects, they reported a high degree of success, only two of the subjects reporting ‘‘no relief.' One of the subjects broke out in a rash and quit the test. Holmes extended this work to food allergies and, in 1943, published his results on 27 patients indicating 80 percent success with 500 milligrams of ascorbic acid a day. He notes that while ascorbic acid is nontoxic, he did observe several cases out of a large number where the patients suffered headaches or sore spots around the mouth and, in one instance, diarrhea.
Apparently there is a low percentage in the population of individuals hypersensitive to ascorbic acid who show these reactions to ascorbic acid even though Korbsch (5), in 1938, reported that ascorbic acid in oral doses up to 1 gram a day relieved serumrashes, erythema multiforme (a type of skin rash), and allergic coryza. A possible way of avoiding these reactions may be to build up gradually to the high dosage intakes rather than starting directly with the high levels.
Pelner (6), in 1944, showed that an extremely sensitive ragweed patient could be protected against adverse reactions to pollen-antigen injections by incorporating 100 milligrams of ascorbic acid with the injection. Pelner had also found previously, in 1943, that he could similarly prevent adverse reactions in a series of 51 patients to sulfonamide injections and, in 1942, he prevented the allergic reactions of a rheumatic fever patient to salicylates. Two other papers by Hebald and Engelsher (7) appeared in 1944. Both claimed that ascorbic acid at 500 milligrams per day is not an effective treatment for hay fever. From these contradictory reports, it is evident that 500 milligrams a day is just marginal in hay fever treatment, giving the typical good results with some investigators and outright failures with others. From the lessons learned in Yokoyama's (3) anaphylactic tests on guinea pigs, it is likely that the higher levels of megascorbic therapy would produce more consistent and successful results.
Ruskin, in 1945, concluded as a result of his studies that ascorbic acid plays a valuable role in treating allergies at an optimum dosage of 750 milligrams daily either orally or by injection. In some cases the ascorbic acid therapy alone proved superior to the pollen desensitization used previously. A paper by Friedlander and Feinberg, appearing in 1945, also indicated that 500 milligrams of ascorbic acid daily was insufficient to change the clinical course of hay fever and asthma (8).
Ruskin, 1947, published another paper reporting that sodium ascorbate was more effective than ascorbic acid in refractory cases of allergy and asthma at 1,200 to 1,500 milligrams per day. In 1948, Ruskin published another paper along similar lines and indicated additional successful results. In a study conducted in both Boston and New York on sixty hay fever patients given 1,000 to 2,250 milligrams of ascorbic acid daily along with a few milligrams of vitamin B,, as reported in 1949, Brown and Ruskin concluded that about 50 percent of their hay fever patients taking the lower dosage and about 75 percent of the patients on the higher doses showed improvement. They stated, “The larger dose may have played a part in producing the apparently greater improvement in the larger percentage of patients.'' In this test series, one subject reported a laxative effect, two reported flushing and headache, and one reported a rash around the eyes and the scientists stated, “Approximately 5 percent of the patients may suffer mild, although easily controlled, side reactions” (9).
The reader now has a representative review of the clinical research on the use of ascorbic acid in the treatment of hay fever at levels from 100 milligrams to 2,250 milligrams a day. It shows the confusing results at the lower levels of treatment and the greater percentage of success as the dosages were increased. Yet in all these tests the dosages of ascorbic acid used were much below the levels of ascorbic acid indicated by current calculations to be synthesized in the liver of an equivalent-sized mammal under equivalent stress. No one in all these years has been inspired to test dosages of ascorbic acid more closely related to these mammalian levels in spite of the suggestive results of previous clinical tests that the degree of success was dose-related. The protocols of any future clinical tests on hay fever should include the year-round daily intakes of 3 to 5 grams of ascorbic acid (Note: 1gram = 1,000mg ascorbic acid), in spaced doses and at higher levels during the particular hay fever season (with and without other antihistamines). The seasonal dosage would be adjusted, depending on the results obtained. If hay fever sufferers were to organize and make enough noise, these tests would be conducted.
Note: Use a good quality Ascorbic acid, made in the USA, third party tested. I choose Nutricost brand, Ascorbic acid Vitamin C because it met all my requirements and it is fairly cheap $20 for 1lb. I am taking one gram (¼ tsp.) powder in half a glass of water 3x/daily. That's 3,000mg. I've tried tablet's before and they did not work (I later discovered they were sourced from Chinese Pharmaceutical Manufacture “Spring Valley Brand at Walmart” = CRAP)
