My husband has Dupuytren's contracture as well. He applies a mixture of iodine, magnesium oil and dmso to his hand twice a day and just rubs it in. The knots are about gone and his hand is flexible. This is after about two weeks of consistent application of the mixture. I believe the iodine is the key. Then the dmso helps drive the iodine further into the skin and the magnesium oil helps keep it moist. It seems like a miracle to him. His doctor has Dupuytren's and had surgery. Now the doctor has a long scar across the palm of his hand. Generally the knots return within a year and apparently consistent surgery would be the remedy. I think a little mixture to soften and prevent it is more sensible, cheaper and keeps it at bay. I'm sure diet helps as well.