I have battled chronic fatigue for more than 20 years. Sometimes it's baffling; it comes and goes. However, I have managed to keep working all this time because of the natural remedies I've used. The XMRV viral connection makes sense to me. I had Epstein-Barr virus. I treated this with the essiac fomula very successfully, and I am due for another brewing. It might be worth a try. It turns my energy around with a week of taking the brew morning and night on an empty stomach. Essiac is said to kill viruses and cancer cells in the bloodstream. I'd like to add that I took the essiac formula to my cousin and his partner, who had come down with AIDS many years ago. To this day, they still take it, and it has been a literal life saver for them. Chronic fatigue can also have a thyroid component, and also adrenal exhaustion may play a part, or a combination. A homeopathic doctor told me years ago that my mitochondria were dysfunctional. The mitochondria are organisms that live in our cells. They consume sugar and release energy, giving us energy at the cellular level. If this is not working correctly, you will not have any energy being supplied to your body. The mitochondria can be effected by viruses, candida, etc.! I'm currently looking into how to support the mitochondria. Anyone out there have any suggestions for that?