Alzheimer's Disease (AD) is the most common neurodegenerative disease in the world and is a huge and growing health burden for our current medical system to deal with at great expense. Unfortunately, the currently available drugs are only marginally helpful for patients who are mild to moderate in terms of disease symptoms and their effects seem to be short-lived in many cases.
In China, they have been testing GV-971, which is derived from a specific form of seaweed that is abundant there, for many years for use as a treatment for AD. They have finished initial testing in China and GV-971 is now available there for people with AD. Currently, they are also doing additional testing in North America and Canada, but that testing is still ongoing. Here is a link to a description of GV-971 and what previous GV-971 studies have shown regarding its usefulness for AD :
GV-971 has several methods of action, but interestingly, one of its main methods of action is manipulation of the gut microbiome to reduce neural inflammation and protect neurons, while reducing oxidative stress.
Interestingly they are just starting testing GV-971 for Parkinson's disease also as noted in this report :
This is really good news because the currently available drugs for AD are only marginally effective in mild to moderate AD and their usefulness can dwindle fairly quickly in some PD patients or offer no benefit in others. Add in the known side effects associated with one of the more common drugs in this class of drugs, Aricept, and you quickly start to realize the importance of GV-971. Here is a link to side effects seen in some Aricept users :
It is worth noting that they are considering further studies at even higher dosing in the future to find out if higher dosing can cause further or better response in people with AD. As far as I am aware, this is the first new drug that has come available for AD in many years in the whole world. In the human trials so far for GV-971 at the currently prescribed dose, showed a safety profile similar to the placebo group. In the trials for GV-971, it showed clear and sustained benefit when compared to the placebo group from week four right through to the 32nd week or trial end.
They have not said when the US and Canadian studies will be completed, but as soon as they are, GV-971 may become a reality here once the FDA approves it. For now, China has already added it to their "National Drug Reimbursement List " (NDRL) and reduced the price by 60%. The original price was RMB 895 ($140.16 usd) and was lowered to RMB 296 ( $46.50 usd). Generally, the US pays more for pharmaceuticals, so it will likely be significantly more than these numbers when it comes available here.
Hello everyone, My dad has Alzheimer's and was having two bad days and nights of asking every few mintues to take him back home and that he move out of the house and wanted to know how the furniture got back to the house he live in right now. My mom had not slept so my sister called and ask if I would go and spend time with my Dad so she could rest for awhile... I give God the Glory and Honor for this: I cut a whole lemon in half and squeeze all the juice and pulp in a glass of water put sweet and low to give it a little taste with some ice and he drank it in about 20min he stop asking about the other house. And another 15 minutes past by and he said he was going to go take a shower and he got up from his chair and took a shower. Since my Dad have been sick he hate to take shower. Please try it, I saw this work on my dad so my mom and sister went and bought a big bag of lemons and will start a morning and night routine... Stay Blessed
(San Antonio, Texas, Usa)
(San Antonio, Texas,usa)
(Worden, Il, Usa)
(Appleton, Ny Usa)
(San Antonio, Texas, Usa)
(Appleton, Ny, Usa)
(San Antonio, Texas, Usa)
(San Antonio, Texas, Usa)
(San Antonio, Texas, Usa)
(New York, US)
(Bologna - Italy)
Alzheimer's cured with lithium aspartate???
Lithium, the rediscovered (missing?) element for your brain's regeneration
The Misunderstood Mineral
By Jonathan V. Wright, M.D.
(Reprinted From "Nutrition and Healing"
excerpt: There are many other research findings that also strongly suggest that lithium will protect against potential Alzheimer's disease and slow the progression of existing cases. Researchers have reported that lithium inhibits beta-amyloid secretion, and also prevents damage caused by beta-amyloid protein once it's been formed.20-23 Beta-amyloid peptide is a signature protein involved in Alzheimer's disease: the more beta-amyloid protein, the worse the Alzheimer's becomes...
Lithium Orotate - Alzheimers Disease, Aluminum, Fibromyalgia: Is There a Relationship?
excerpt:Chris D. Meletis, N.D. reports in Vitamin Research News, "Studies show that lithium, in general, inhibits the atrophy of the hippocampus. Atrophy of the human hippocampus is seen in a variety of disorders including Alzheimer's disease."(1)
(Sydney, New South Wales, Australia)
My husband was on 3 heart pills and 3 pills for blood sugar. He also took Trazadone and some others per the VA and was then diagnosed with Alzheimer's.
We started MMS, plant food diet, herbs, lots of water, and vitamins. He was taken off all pills and communicated with us. We did lots of our own research. That was 7 years ago. It is worth it to research everything, the truth is out there.
My Dad is 87 and has Alzheimer's. I went to visit him last weekend (He lives near my siblings, ten hours away.) I only get to see him every few months. I arrived and he was sitting on the edge of his bed. I greeted him and he wasn't very responsive. He wasn't sleepy, he was just kind of vacant. I encouraged him to get up and go sit with me and several of my kids in the living area. He was having a hard time comprehending basic directions. He was making a repetitive noise, which was new for him since I last saw him. I was feeling pretty discouraged.
We got to the living room. My kids had stringed instruments and started to play. They played some songs that I knew he loved and had been singing for more than half a century. Dad immediately perked up. He sang along, he smiled, he showed nostalgic recongnition. He even stood up and started "directing." We sang and sang and sang. He clearly enjoyed it. What was interesting is that he seemed mentally better after we had been singing. When I had arrived, I don't think he knew I was his daugther or even someone he knew. Later he was introducing me to someone as his daughter. He couldn't recal my name. I supplied it and he said, "Oh, yes, " and then he said my middle name.
I have seen music affect my babies. I have seen music help children learn to read. And I know it is powerful.
I wonder what would happen if my Dad had a lot more singing time each day.
The nursing home where he lives does work hard to cater to the needs of memory care patients. The movies they play are the oldies that most residents would rememember from younger days - lots of black and white movies, even. Every day during meal time they play "big band" music. I have often seen my dad begin to dance a little when he hears the music. He loved to dance as a younger man even taught ballroom dancing.
I know research is being done with regards to the elderly and music. I would love to understand it more. But meanwhile, I know that music helps the brain, even of those with Alzheimer's.
How to put this into practice? If you have a loved one with Alzheimer's, make a point of playing music they loved when they were younger. Sing with them, when you can. I don't think all music is equally helpful. Music is emotional - it evokes happiness, depression, anger, excitement, restlessness, peacefulness. So be mindful what the music you chose is going to promote.
I am also convinced that complex classical music does amazing things for the brain. If you do not know where to start with classical music, start with Bach. It will keep you busy for years. Play Bach for the elderly people you love. Play it for your babies and toddlers and children, too. In fact, play it for yourself. I think it is something from which everyone can benefit.
"To send light into the darkness of men's hearts, such is the duty of the artist." Robert Schumann (German composer from the 1800's).
A new movie documenatary is on the market and in theatres of a study done in nursing homes with music specifically arranged for each person that lights up their brain and they are seeing vast improvement in seniors locked in a world of their own. I found out yesterday ... spread the news. Here's a 30 minute interview with the filmmaker on YouTube. https://www.youtube.com/watch?v=TEaBER0bUbc
Prevent Alzheimers Disease with Nattokinase. Here is explanation:
Alzheimer's disease occurs when there's a build-up of amyloid. Amyloid is oxidized protein. It's a waste product that builds up inside all non-dividing cells. This includes the cells in your heart, brain, kidneys, etc. It builds slowly. And it slowly shuts down the ability of your cells to properly function. It irritates them, sort of like a chigger on your skin. Your brain cells are particularly sensitive.
It's rare to find a compound that can dissolve amyloid. But recently, researchers discovered that my favorite enzyme, nattokinase, cleaves to the protein and enhances its removal. What's interesting is that other protein dissolving enzymes, including trypsin and plasmin, don't do it. Trypsin is a protein-dissolving enzyme made by your pancreas. Plasmin is a protein in your blood that dissolves clots.
Interestingly, nattokinase got its fame as a clot buster or clot preventer. Now science is showing its superiority in dissolving this other unwanted protein.
I noticed Nattokinase was missing from Earth Clinic's Alzheimer remedy list.
My father has been taking 325 mg of "no flush" niacin for 4 months. (I would like to see him taking more, but he takes a lot of medication and even getting in that one pill a day is a step in the right direction.)
I, and others, have noticed a lessening of his Alzheimer's/Dementia symptoms. He is less confused. He is sharper. As mentioned in another post, I just got back from a visit with him. We played cards. He played a spelling bee type game with my son. He would not have done these things a few months ago.
After my mother passed away four months ago, we expected my dad to decline steadily. He is doing so much better than we expected. He does have less stress now (watching your spouse die of Alzheimer's over the course of a couple of years is very stressful.) He is also getting regular exercise. Those and the niacin may all be contributing to his improved mental condition. Whatever it is, we are glad!
~Mama to Many~
While it is encouraging to discover that B3 vitamin appears to be helpful in effecting the course of Alzheimer's positively, yet not completely to the point of reversal or even as a prophylactic, one has to ask the question why there is so much emphasis on one agent, when in fact all chronic diseases are a result of multiple deficiencies. Can people not think in multiple factorials? Or is it mental laziness that prompts people and scientists to want single solutions for diseases which they have decided are a single entity caused by a single factor or agent. All agents that will help to energize brain cells, such as D ribbose, creatine, MSM, coconut oil, coQ10, should be taken into consideration. One must also remember that toxins such as aluminium, fluoride and mercury are neurotoxic and probably play a major role in causing mental deterioration. If such factors are ignored, the research done on any disease becomes null and void and of no value what so ever.
(Bologna - Italy)
I would like to share how I cured my 89 year old mother from Alzheimer's!
Six years ago my mother was diagnosed by a very reputable specialist with Alzheimer's. At the time she had difficulty remembering things she had done that day. She would ask the same questions over a lot. She would say things that did not make sense and she had become quite angry and irrational. The doctor told us that her condition would continue to deteriorate and that within about 3 years she would not be able to function on her own (even at that time she needed full-time caregivers to remind her what to do).
I am a holistic health practitioner and so I am familiar with a lot of supplements, herbs and foods to cure different conditions. So I started her on some of the supplements that I knew about for Alzheimer's. These included Phosphatidylserine (PS), L-Carnitine, Tumeric, Ginkgo and vinpocetine as well as a multi-vitamin. Two years after she started this protocol she went back for a follow up appointment with the Alzheimer's specialist who had originally diagnosed her. He was quite surprised that her condition had remained the same for two years and not progressed as he said it would. I believe that these supplements halted the progression of the Alzheimer's. But we really wanted to see improvement.
Here is where the cure comes in!
I had read about studies done using Niacinamide to cure Alzheimer's. The studies suggested giving it in small doses many times throughout the day to keep constant levels in the bloodstream. It suggested giving an oral dose of Niacinamide 12 times a day! This is very impractical for my mother who struggles to take all of her other pills. So we ended up giving her a 500 mg. capsule three times a day with meals.
At this time I had also read about studies showing that high doses of vitamin A actually dissolves Beta Amyloid deposits in lab animals. The study found that it not only dissolved the deposits, but it did so in a matter of hours! The article I read which was published by a doctor recommended a form of vitamin A called “Mycellized A" in liquid form as this is better absorbed. So I also started her on the mycellized vitamin A.
After starting her on these two new supplements (Niacinamide 500 mg 3 times a day, and Mycellized Vitamin A 100, 000 mg. a day for 3 weeks, (then cut back to 20, 000 mg a day maintenance) we noticed a big improvement.
Later we added a couple of other things which I believe helped her as well. One of them is Coconut oil. The other is to make sure that she does not have a bladder infection. My mother is prone to UTI's and we noticed that whenever she got one that her mental symptoms would get much worse. So we have to make sure that those are kept in check. As long as we are doing all of these things she does great.
It has been 6 years since her diagnosis and instead of progressing her Alzheimer's is gone for the most part. She is now back to her old self. Her thinking and cognition are good. She remembers almost everything about her day. She rarely repeats questions, her attitude is so much better. She is not angry or unreasonable anymore. She actually has conversations with me now where she can give me helpful advice on problems I may have. She's back to acting like my mom again! To recap, I feel that what really helped her the most has been the Niacinamide and the Mycellized vitamin A, and secondarily the coconut oil and preventing UTI's. Please try these as they may work for you as well.
A note about UTI's: It is quite well known by nursing home staff that when an elderly person gets a UTI that it really affects them mentally. It can cause confusion, anger, and unreasonable behaviors. This is important-elderly people do not always have the typical symptoms on a UTI (frequent or burning urination, etc.) This is why it is so important if an elderly person is struggling with mental symptoms, especially if they come on suddenly that they go to a doctor and have a urine test done to check for a UTI. Usually they will perform a dipstick test on the urine at the doctor's office to check for bacteria and traces of blood. But if the dipstick test does not find anything please ask your doctor to send a sample of the urine to a lab for culture. This is a very simple thing for them to do. There are times that the culture will pick up an infection when the dipstick test does not. I hope that this information helps others who are suffering with Alzheimer's as my mother was. It is a difficult disease but I believe it can be cured with the above protocol. My mother is living proof!!!
(New York, US)
(New York, US)
(Maricopa County, Phoenix, Arizona)
(Palm Bay Fl)
I have recently researching the amazing nutrient Pyrroloquinoline Quinone or PQQ. PQQ has proven effective in restoring my damaged mitochondria and thus restoring energy and also insuring longevity, but more research is finding it's efficacy in preventing or treating Alzheimer's & Parkinson's disease.
Hope this link works for further reading.
Alzheimer's Disease (AD) is a tough disease that is growing each year in the number of people it affects. Unfortunately the currently available medications are not very effective at treating the disease process and are even less effective for some people with AD. It is estimated that 5.7 million Americans are now living with AD!
With the Baby Boomers now in the senior citizen range, the number of people with AD is expected to reach unprecedented proportions that could potentially bankrupt are medical system because of the tremendous costs involved in the care of AD patients. These costs will continue to rise over time.
Given the poor prognosis for AD patients in general with the currently available meds that are unable to stop the disease process, we need alternatives to act as adjunctive help to go along with the prescription meds.
On that note, the following study shows that a 12 week course of a specific probiotic treatment was able to improve some disease symptoms in the treated patients. What is good about this study is that it is an actual human study as opposed to a mouse or rat study because those models do not always equate to humans in a like manner. A good example of this was the niacinamide mouse study that was done at the University Of Irvine California that showed almost complete reversal of AD symptoms in the AD model mice. The results were so good that a human study was done shortly after the results from the mouse study were released. Unfortunately the human study showed only marginal benefit at best for people with AD.
Here is a link to the probiotic / AD study:
Another great point to this study is that the positive results were seen in just 12 weeks! It makes you wonder if a longer study period would have produced even better results. Another great positive to this studies is that other health parameters were improved along with cognition!
Probiotics have a good safety profile, are readily available and the ones used in this study are not the exotic ones which are almost impossible to find when you search. This is great news for people living with this horrible disease that affects not only the patient, but their family, friends and caregivers negatively.
I started taking Serrapeptase for the first signs of dementia and it's helping a lot. After reading your newsletter, it may be the reason my inflammation has been a doing so much better also.
There are two studies that seemed to link this to the fact that drinking soy milk can help Alzheimers that I think is remotely interesting.
One study showed that the brain of an alzheimer's patient is extremely low in hydrogen sulfide, while on the other hand, it was found that baby infants who drink soy milk had high levels of hydrogen sulfide.
Now I am not saying that hydrogen sulfide is good or bad, it is one of the three gaseous molecules the body uses to control, many biological functions. The other two is nitric oxide and carbon monoxide produced in very low amounts to control the body's physiology.
It is quite possible that by taking soy, Alzheimers might be helped, remotely anyway, through the increase in hydrogen sulfide through driking soy milk. The reason being is Alzheimer's brains are low in hydrogen sulfide while soy milk causes increase in hydrogen sulfide. Ted"
Here are the two research studies. By the way, neither soy nor cow's milk is recommended for infants.
1: J Pediatr Gastroenterol Nutr. 2001 May;32(5):534-41.
Gas production by feces of infants.
Jiang T, Suarez FL, Levitt MD, Nelson SE, Ziegler EE.
Fomon Infant Nutrition Unit, Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
BACKGROUND: Intestinal gas is thought to be the cause abdominal discomfort in infants. Little is known about the type and amount of gas produced by the infant's colonic microflora and whether diet influences gas formation. METHODS: Fresh stool specimens were collected from 10 breast-fed infants, 5 infants fed a soy-based formula, and 3 infants fed a milk-based formula at approximately 1, 2, and 3 months of age. Feces were incubated anaerobically for 4 hours at 37 degrees C followed by quantitation of hydrogen (H2), methane (CH4), carbon dioxide (CO2), hydrogen sulfide (H2S), methanethiol (CH3SH), and dimethyl sulfide (CH3SCH3) in the head-space. RESULTS: H2 was produced in greater amounts by breast-fed infants than by infants in either formula group, presumably the consequence of incomplete absorption of breast milk oligosaccharides. CH4 was produced in greater amounts by infants fed soy formula than by infants on other diets. CO2 was produced in similar amounts by infants in all feeding groups. Production of CH3SH was conspicuously low by feces of breast-fed infants and production of H2S was high by soy-formula-fed infants. CH3SCH3 was not detected. Only modest changes with age were observed and there was no relation between gas production and stool consistency, although stools were more likely to be malodorous when concentrations of H2S and/or CH3SH were high. CONCLUSIONS: Gas release by infant feces is strongly influenced by an infant's diet. Of particular interest are differences in production of the highly toxic sulfur gases, H2S and CH3SH, because of the role that these gases may play in certain intestinal disorders of infants.
Alzheimer is low in hydrogen sulfide: Brain hydrogen sulfide is severely decreased in Alzheimer's disease
Authors: Eto K.1; Asada T.2; Arima K.2; Makifuchi T.3; Kimura H.1
Source: Biochemical and Biophysical Research Communications, Volume 293, Number 5, May 2002, pp. 1485-1488(4)
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine-synthase (CBS). H2S functions as a neuromodulator as well as a smooth muscle relaxant. Here we show that the levels of H2S are severely decreased in the brains of Alzheimer's disease (AD) patients compared with the brains of the age matched normal individuals. In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine. Previous findings, which showed thatS-adenosyl-l-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed. These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD.
(Seattle, Wa Usa)
(Emerald City, The Land Of Oz)
Cure of cognitive impairment of down syndrome may help Alzheimer's sufferers.
Changing minds is a protocol to treat the cognitive impairment seen in down syndrome. After only 13 weeks of treatment the IQ start to rise. Here you can find the protocol, a documentary trailer, testimonies and research:
and here you can see other fragments. Watch nichole who has a dual diagnostic of down syndrome + alzheimer.
keep in mind that The connection between Down syndrome and Alzheimer's disease is complex. Studies of the brains of people with Down syndrome reveal that, by the age of 40, almost all develop the brain changes characteristic of Alzheimer's disease.
I know the protocol use 2 prescription drugs, but one is no necessary, the other one is prosac, and its main use is for neurogenesis= creation of new neurons with strong synapses. so there is possible cure for the cognitive impairment, and the article about the lithium is very interesting, looks like it does the same as prosac. exercise stimulate neurogenesis and THC also.
Ginkgo Biloba - In 2003, Stanford University discovered the main culprit, GABA receptor, an inhibitor, was ON continuously in individuals with Down syndrome. (View details) The result was- it did not allow the nerves in the memory area of the brain to fire. To get the proper level of GABA, a GABA antagonist was used to turn it down. (View details) Ginkgo Biloba is a GABA antagonist which has been used for over 4000 years (View details)
Prozac - The University Of Maryland School Of Medicine treated Down syndrome mice with prozac for 24 days (2006). It increased neurogenesis (the formation of new nerves) to a normal level (View details). This is like increasing the hardware on your computer. It allows you to run more complicated software. In fetuses with Down syndrome, neurons fail to show normal dendritic development, yielding a "tree in winter" appearance. This developmental failure is thought to result in mental retardation (View details)
Focalin XR is an ADHD medicine that increases focus and decreases impulsiveness and hyperactivity. It is a mild stimulant. As our children improved, we became increasingly aware of their inability to attend to the tasks at hand.
Phosphatidylcholine is a phospholipid that makes up 50% of the cell membrane. The membrane is the lining of every nerve cell that carries our signals. We are trying to heal the brain by growing new neurons and allowing them to fire. Giving PC is like bringing the bricks to the construction site when building a house. (View details)
Formulated with a 4:1 Ratio of Omega 6 to Omega 3 in Liquid form or Softgel pills.
Of the tens of thousands of molecules that make up the life of a cell, Phosphatidylcholine (PC) stands apart; probably the most important one of all. BodyBio PC is made of only pure phospholipids which automatically form liposomes in the watery environment of the body, but it goes one important step further.... it is also formulated with the essential lipids at a 4:1 ratio. Most PC currently available has an EFA ratio of ~12:1. BodyBio PC not only has a higher concentration of PC, up to 66% but also maintains EFA concentration at the preferred 4:1 ratio, a BodyBio exclusive.
Body Bio Balanced Oil
Body Bio Oil - There is a growing body of evidence that inflammation and degeneration go hand in hand. This oil provides the body with the building blocks to reduce inflammation and improve health. Link to references
4:1 Ratio of Organic Sunflower and Flax Seed Oil Blend in its Virgin State. Fatty acids are not only good for you -- they are ESSENTIAL! One of the very best supplement programs includes additional Essential Fatty Acids of Omega 6 to Omega 3 at a 4:1 ratio. This special formulation of organic sunflower and flax is now available as BODYBIO BALANCE!
Folinic Acid/ B 12 (methylcobalamin)
Folinic Acid/ B 12 (methylcobalamin) - Dr. Jill James has a detailed study looking at methylation and the need for these nutrients in the patient with Down syndrome. (View Details)
- Ginkgo Biloba - The dose is approximately 2.5 mg/lb for the dry herb but must be adjusted on the basis of clinical response and tolerability.
- Prozac - The dose needs to be adjusted in the range of 5 mg to 20mg/day on the basis of clinical response and tolerability.
- Focalin XR - dosage should be individualized according to the needs and responses of the patient
- Phosphatidylcholine - depends on age, check table below
- Body Bio Oil - depends on age, check table below
- Folinic Acid/ B 12 depends on age, check table below