My father has been taking 325 mg of "no flush" niacin for 4 months. (I would like to see him taking more, but he takes a lot of medication and even getting in that one pill a day is a step in the right direction.)
I, and others, have noticed a lessening of his Alzheimer's/Dementia symptoms. He is less confused. He is sharper. As mentioned in another post, I just got back from a visit with him. We played cards. He played a spelling bee type game with my son. He would not have done these things a few months ago.
After my mother passed away four months ago, we expected my dad to decline steadily. He is doing so much better than we expected. He does have less stress now (watching your spouse die of Alzheimer's over the course of a couple of years is very stressful.) He is also getting regular exercise. Those and the niacin may all be contributing to his improved mental condition. Whatever it is, we are glad!
~Mama to Many~
Niacinamide worked for my mother's dementia. The dosage was time-release 1500 mg twice a day (breakfast and bedtime).
She went from asking the same question every 60 seconds (for example, she would ask where my father was, we'd answer that he was in the hospital, then seconds later she'd ask again) and being unable to take a shower because she couldn't remember how to do it, to being 100% her old normal self pre-dementia.
She can now shower and dress herself and apply her own make-up. She is back to cooking my parents' meals. She keeps the house clean. She remembers answers to questions. She is able to participate in conversations. She remembers events of the past few years that she had completely lost. She knows what year it is. She knows her age and my father's age.
Also, she had gotten very erratic emotionally. Now she's got her old personality back.
She got it all back.
She had no trouble with side effects.
We've been tapering down her dosage to see how she handles it. Right now she's on 1000 mg time release 2x a day, and so far so good.
Las Vegas, Nv
Northland, New Zealand
Las Vegas, Nv
Buenos Aires Argentina.
Fountain Inn, Sc
I couldn't find "Niacinamide" nor "B3" listed under the big main "Supplements" Tab, so I'll put it here.
Also, I note some topics have a "Remedies Wanted" URL link on the right, yet others like this Alzheimers don't?
Supposedly, according to very recent research at UC Irvine on mice, daily high doses of plain old niacinamide form of Vitamin B3 (NOT the niacin form, which gives the "hot flush"), in amounts equivalent to 2000-3000 mg/day per adult human divided into 4 doses, totally reverses Alzheimers within about 4 months!
The B Vitamins are all water soluble, so like Vitamin C to get maximum flooding of body tissues they need to be taken in doses spread out throughout the day.
Any Search with about 4 of the keywords will return dozens of results. This one is late 2009:
How does niacinamide work? Neurons are constructed with microtubules. These are scaffolding within the cells that conduct information. When the microtubules break down, the cells can die.
The tubules are like highways inside cells. Dr. Green said that niacinamide is "making a wider more stable highway. " Alzheimer's disease breaks down the highway (tubules). But niacinamide prevents this from happening.
I've previously told you how the toxic metal mercury also destroys these microtubules, potentially causing Alzheimer's disease. So anything that can prevent the damage or reverse it is a huge discovery.
Note that the mice were bred with a genetic defect to produce the amyloid plaques, so it seems the niacinamide just completely overrides that. IOW, it did not eliminate the plaques!
The articles in the Search give slight variants of the dosage. Another article says " 500mg 4 to 6 times/day".
If you have dementia of any kind, consider niacinamide, 1,500 mg twice daily.
Manganui, Northland, New Zealand
Italy - Bologna
I would like to share how I cured my 89 year old mother from Alzheimer's!
Six years ago my mother was diagnosed by a very reputable specialist with Alzheimer's. At the time she had difficulty remembering things she had done that day. She would ask the same questions over a lot. She would say things that did not make sense and she had become quite angry and irrational. The doctor told us that her condition would continue to deteriorate and that within about 3 years she would not be able to function on her own (even at that time she needed full-time caregivers to remind her what to do).
I am a holistic health practitioner and so I am familiar with a lot of supplements, herbs and foods to cure different conditions. So I started her on some of the supplements that I knew about for Alzheimer's. These included Phosphatidylserine (PS), L-Carnitine, Tumeric, Ginkgo and vinpocetine as well as a multi-vitamin. Two years after she started this protocol she went back for a follow up appointment with the Alzheimer's specialist who had originally diagnosed her. He was quite surprised that her condition had remained the same for two years and not progressed as he said it would. I believe that these supplements halted the progression of the Alzheimer's. But we really wanted to see improvement.
Here is where the cure comes in!
I had read about studies done using Niacinamide to cure Alzheimer's. The studies suggested giving it in small doses many times throughout the day to keep constant levels in the bloodstream. It suggested giving an oral dose of Niacinamide 12 times a day! This is very impractical for my mother who struggles to take all of her other pills. So we ended up giving her a 500 mg. capsule three times a day with meals.
At this time I had also read about studies showing that high doses of vitamin A actually dissolves Beta Amyloid deposits in lab animals. The study found that it not only dissolved the deposits, but it did so in a matter of hours! The article I read which was published by a doctor recommended a form of vitamin A called “Mycellized A" in liquid form as this is better absorbed. So I also started her on the mycellized vitamin A.
After starting her on these two new supplements (Niacinamide 500 mg 3 times a day, and Mycellized Vitamin A 100, 000 mg. a day for 3 weeks, (then cut back to 20, 000 mg a day maintenance) we noticed a big improvement.
Later we added a couple of other things which I believe helped her as well. One of them is Coconut oil. The other is to make sure that she does not have a bladder infection. My mother is prone to UTI's and we noticed that whenever she got one that her mental symptoms would get much worse. So we have to make sure that those are kept in check. As long as we are doing all of these things she does great.
It has been 6 years since her diagnosis and instead of progressing her Alzheimer's is gone for the most part. She is now back to her old self. Her thinking and cognition are good. She remembers almost everything about her day. She rarely repeats questions, her attitude is so much better. She is not angry or unreasonable anymore. She actually has conversations with me now where she can give me helpful advice on problems I may have. She's back to acting like my mom again! To recap, I feel that what really helped her the most has been the Niacinamide and the Mycellized vitamin A, and secondarily the coconut oil and preventing UTI's. Please try these as they may work for you as well.
A note about UTI's: It is quite well known by nursing home staff that when an elderly person gets a UTI that it really affects them mentally. It can cause confusion, anger, and unreasonable behaviors. This is important-elderly people do not always have the typical symptoms on a UTI (frequent or burning urination, etc.) This is why it is so important if an elderly person is struggling with mental symptoms, especially if they come on suddenly that they go to a doctor and have a urine test done to check for a UTI. Usually they will perform a dipstick test on the urine at the doctor's office to check for bacteria and traces of blood. But if the dipstick test does not find anything please ask your doctor to send a sample of the urine to a lab for culture. This is a very simple thing for them to do. There are times that the culture will pick up an infection when the dipstick test does not. I hope that this information helps others who are suffering with Alzheimer's as my mother was. It is a difficult disease but I believe it can be cured with the above protocol. My mother is living proof!!!
New York, US
New York, US
Maricopa County, Phoenix, Arizona
I have recently researching the amazing nutrient Pyrroloquinoline Quinone or PQQ. PQQ has proven effective in restoring my damaged mitochondria and thus restoring energy and also insuring longevity, but more research is finding it's efficacy in preventing or treating Alzheimer's & Parkinson's disease.
Hope this link works for further reading.
Alzheimer's Disease (AD) is a tough disease that is growing each year in the number of people it affects. Unfortunately the currently available medications are not very effective at treating the disease process and are even less effective for some people with AD. It is estimated that 5.7 million Americans are now living with AD!
With the Baby Boomers now in the senior citizen range, the number of people with AD is expected to reach unprecedented proportions that could potentially bankrupt are medical system because of the tremendous costs involved in the care of AD patients. These costs will continue to rise over time.
Given the poor prognosis for AD patients in general with the currently available meds that are unable to stop the disease process, we need alternatives to act as adjunctive help to go along with the prescription meds.
On that note, the following study shows that a 12 week course of a specific probiotic treatment was able to improve some disease symptoms in the treated patients. What is good about this study is that it is an actual human study as opposed to a mouse or rat study because those models do not always equate to humans in a like manner. A good example of this was the niacinamide mouse study that was done at the University Of Irvine California that showed almost complete reversal of AD symptoms in the AD model mice. The results were so good that a human study was done shortly after the results from the mouse study were released. Unfortunately the human study showed only marginal benefit at best for people with AD.
Here is a link to the probiotic / AD study:
Another great point to this study is that the positive results were seen in just 12 weeks! It makes you wonder if a longer study period would have produced even better results. Another great positive to this studies is that other health parameters were improved along with cognition!
Probiotics have a good safety profile, are readily available and the ones used in this study are not the exotic ones which are almost impossible to find when you search. This is great news for people living with this horrible disease that affects not only the patient, but their family, friends and caregivers negatively.
Seattle, Wa Usa
Emerald City, The Land Of Oz
There are two studies that seemed to link this to the fact that drinking soy milk can help Alzheimers that I think is remotely interesting.
One study showed that the brain of an alzheimer's patient is extremely low in hydrogen sulfide, while on the other hand, it was found that baby infants who drink soy milk had high levels of hydrogen sulfide.
Now I am not saying that hydrogen sulfide is good or bad, it is one of the three gaseous molecules the body uses to control, many biological functions. The other two is nitric oxide and carbon monoxide produced in very low amounts to control the body's physiology.
It is quite possible that by taking soy, Alzheimers might be helped, remotely anyway, through the increase in hydrogen sulfide through driking soy milk. The reason being is Alzheimer's brains are low in hydrogen sulfide while soy milk causes increase in hydrogen sulfide. Ted"
Here are the two research studies. By the way, neither soy nor cow's milk is recommended for infants.
1: J Pediatr Gastroenterol Nutr. 2001 May;32(5):534-41.
Gas production by feces of infants.
Jiang T, Suarez FL, Levitt MD, Nelson SE, Ziegler EE.
Fomon Infant Nutrition Unit, Department of Pediatrics, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA.
BACKGROUND: Intestinal gas is thought to be the cause abdominal discomfort in infants. Little is known about the type and amount of gas produced by the infant's colonic microflora and whether diet influences gas formation. METHODS: Fresh stool specimens were collected from 10 breast-fed infants, 5 infants fed a soy-based formula, and 3 infants fed a milk-based formula at approximately 1, 2, and 3 months of age. Feces were incubated anaerobically for 4 hours at 37 degrees C followed by quantitation of hydrogen (H2), methane (CH4), carbon dioxide (CO2), hydrogen sulfide (H2S), methanethiol (CH3SH), and dimethyl sulfide (CH3SCH3) in the head-space. RESULTS: H2 was produced in greater amounts by breast-fed infants than by infants in either formula group, presumably the consequence of incomplete absorption of breast milk oligosaccharides. CH4 was produced in greater amounts by infants fed soy formula than by infants on other diets. CO2 was produced in similar amounts by infants in all feeding groups. Production of CH3SH was conspicuously low by feces of breast-fed infants and production of H2S was high by soy-formula-fed infants. CH3SCH3 was not detected. Only modest changes with age were observed and there was no relation between gas production and stool consistency, although stools were more likely to be malodorous when concentrations of H2S and/or CH3SH were high. CONCLUSIONS: Gas release by infant feces is strongly influenced by an infant's diet. Of particular interest are differences in production of the highly toxic sulfur gases, H2S and CH3SH, because of the role that these gases may play in certain intestinal disorders of infants.
Alzheimer is low in hydrogen sulfide: Brain hydrogen sulfide is severely decreased in Alzheimer's disease
Authors: Eto K.1; Asada T.2; Arima K.2; Makifuchi T.3; Kimura H.1
Source: Biochemical and Biophysical Research Communications, Volume 293, Number 5, May 2002, pp. 1485-1488(4)
Although hydrogen sulfide (H2S) is generally thought of in terms of a poisonous gas, it is endogenously produced in the brain from cysteine by cystathionine-synthase (CBS). H2S functions as a neuromodulator as well as a smooth muscle relaxant. Here we show that the levels of H2S are severely decreased in the brains of Alzheimer's disease (AD) patients compared with the brains of the age matched normal individuals. In addition to H2S production CBS also catalyzes another metabolic pathway in which cystathionine is produced from the substrate homocysteine. Previous findings, which showed thatS-adenosyl-l-methionine (SAM), a CBS activator, is much reduced in AD brain and that homocysteine accumulates in the serum of AD patients, were confirmed. These observations suggest that CBS activity is reduced in AD brains and the decrease in H2S may be involved in some aspects of the cognitive decline in AD.
Cure of cognitive impairment of down syndrome may help Alzheimer's sufferers.
Changing minds is a protocol to treat the cognitive impairment seen in down syndrome. After only 13 weeks of treatment the IQ start to rise. Here you can find the protocol, a documentary trailer, testimonies and research:
and here you can see other fragments. Watch nichole who has a dual diagnostic of down syndrome + alzheimer.
keep in mind that The connection between Down syndrome and Alzheimer's disease is complex. Studies of the brains of people with Down syndrome reveal that, by the age of 40, almost all develop the brain changes characteristic of Alzheimer's disease.
I know the protocol use 2 prescription drugs, but one is no necessary, the other one is prosac, and its main use is for neurogenesis= creation of new neurons with strong synapses. so there is possible cure for the cognitive impairment, and the article about the lithium is very interesting, looks like it does the same as prosac. exercise stimulate neurogenesis and THC also.
Ginkgo Biloba - In 2003, Stanford University discovered the main culprit, GABA receptor, an inhibitor, was ON continuously in individuals with Down syndrome. (View details) The result was- it did not allow the nerves in the memory area of the brain to fire. To get the proper level of GABA, a GABA antagonist was used to turn it down. (View details) Ginkgo Biloba is a GABA antagonist which has been used for over 4000 years (View details)
Prozac - The University Of Maryland School Of Medicine treated Down syndrome mice with prozac for 24 days (2006). It increased neurogenesis (the formation of new nerves) to a normal level (View details). This is like increasing the hardware on your computer. It allows you to run more complicated software. In fetuses with Down syndrome, neurons fail to show normal dendritic development, yielding a "tree in winter" appearance. This developmental failure is thought to result in mental retardation (View details)
Focalin XR is an ADHD medicine that increases focus and decreases impulsiveness and hyperactivity. It is a mild stimulant. As our children improved, we became increasingly aware of their inability to attend to the tasks at hand.
Phosphatidylcholine is a phospholipid that makes up 50% of the cell membrane. The membrane is the lining of every nerve cell that carries our signals. We are trying to heal the brain by growing new neurons and allowing them to fire. Giving PC is like bringing the bricks to the construction site when building a house. (View details)
Formulated with a 4:1 Ratio of Omega 6 to Omega 3 in Liquid form or Softgel pills.
Of the tens of thousands of molecules that make up the life of a cell, Phosphatidylcholine (PC) stands apart; probably the most important one of all. BodyBio PC is made of only pure phospholipids which automatically form liposomes in the watery environment of the body, but it goes one important step further.... it is also formulated with the essential lipids at a 4:1 ratio. Most PC currently available has an EFA ratio of ~12:1. BodyBio PC not only has a higher concentration of PC, up to 66% but also maintains EFA concentration at the preferred 4:1 ratio, a BodyBio exclusive.
Body Bio Balanced Oil
Body Bio Oil - There is a growing body of evidence that inflammation and degeneration go hand in hand. This oil provides the body with the building blocks to reduce inflammation and improve health. Link to references
4:1 Ratio of Organic Sunflower and Flax Seed Oil Blend in its Virgin State. Fatty acids are not only good for you -- they are ESSENTIAL! One of the very best supplement programs includes additional Essential Fatty Acids of Omega 6 to Omega 3 at a 4:1 ratio. This special formulation of organic sunflower and flax is now available as BODYBIO BALANCE!
Folinic Acid/ B 12 (methylcobalamin)
Folinic Acid/ B 12 (methylcobalamin) - Dr. Jill James has a detailed study looking at methylation and the need for these nutrients in the patient with Down syndrome. (View Details)
- Ginkgo Biloba - The dose is approximately 2.5 mg/lb for the dry herb but must be adjusted on the basis of clinical response and tolerability.
- Prozac - The dose needs to be adjusted in the range of 5 mg to 20mg/day on the basis of clinical response and tolerability.
- Focalin XR - dosage should be individualized according to the needs and responses of the patient
- Phosphatidylcholine - depends on age, check table below
- Body Bio Oil - depends on age, check table below
- Folinic Acid/ B 12 depends on age, check table below
There is a great deal of good research being done on Turmeric for Alzheimer's. Also my father is doing well on this, but he has also recently added BHT to his regime (in case of HSV infection).
Here is some research from Japan:
Effects of turmeric on Alzheimer's disease with behavioral and psychological symptoms of dementia
Ayu. 2012 Oct-Dec; 33(4): 499-504.
We describe here three patients with the Alzheimer's Disease (AD) whose behavioral symptoms were improved remarkably as a result of the turmeric treatment, which is the traditional Indian medicine. Their cognitive decline and Behavioral and Psychological Symptoms of Dementia (BPSD) were very severe. All three patients exhibited irritability, agitation, anxiety, and apathy, two patients suffer from urinary incontinence and wonderings. They were prescribed turmeric powder capsules and started recovering from these symptoms without any adverse reaction in the clinical symptom and laboratory data. After 12 weeks of the treatment, total score of the Neuro-Psychiatric Inventory-brief questionnaire decreased significantly in both acuity of symptoms and burden of caregivers. In one case, the Mini-Mental State Examination (MMSE) score was up five points, from 12/30 to 17/30. In the other two cases, no significant change was seen in the MMSE; however, they came to recognize their family within 1 year treatment. All cases have been taking turmeric for more than 1 year, re-exacerbation of BPSD was not seen. The present cases suggest a significant improvement of the behavioral symptoms in the AD with the turmeric treatment, leading to probable benefit of the use of turmeric in individuals with the AD with BPSD.
In India alzheimer is almost non existent and cancer is more rare, especially male types of cancer. Researchers found that it has to do with the consumption of large quantities of turmeric (also known as kunjit) in the curry. Especially the combination of chilly powder, turmeric and cauliflower and broccoli seems to do the trick. If you prepare a curry don't just use the herbal mix form the grocery but add your own paste of vegetable oil (arachide, sunflower or sesame oil), chilli powder and turmeric powder. Wash and cut the cauliflower and broccoli and let them sit for 15 minutes before cooking, as this improves the health benefits.
Mountain View, California, USA
Manitowoc, Wisconsin, USA
Emerald City, The Land Of Oz
I found an article on MSN dated 5/22/2013...
Vitamin B keeps your brain from shrinking, reduces Alzheimer's risk
"A new study shows that vitamin B supplements reduced brain shrinkage by up to 90 percent in certain areas vulnerable to Alzheimer's, suggesting the vitamin may be more protective than previously thought. Dr. David Smith of Oxford University, who led the study, said, "our work shows that a key part of the disease process that leads to Alzheimer's disease, the atrophy of specific brain regions, might be modified by a safe and simple intervention. " Others caution that there's no magic bullet against Alzheimer's..."
Northland, New Zealand
HI U GOD FEARING FOLKS DOIN, , , , , , , , , , , , , , ,
Just read an interesting article that equated Alzheimer's with the advent of mercury flu shots and folks that stopped smoking. The article had a graph of the last two and the advent of Alzheimer's. The graphs tracked. Upon more research, I learned that tobacco is an herb where our B 3 vitamin comes from. Research has shown that B 3 helps your brain. Mercury does not. The problem with smoking or chewing today's tobacco is not the tobacco, but all the chemicals that has been sprayed on it. That includes insecticides, fungicides, and pesticides. Only a few years ago arsenic was sprinkled on the plant to kill the boll worms. If you smoked you got all that garbage. I don't have a clue about nicotine, but now all the smart people are saying that caffeine is good for you. The problem with coffee is that unless you buy organic you are still getting the stuff that you did with tobacco. They spray coffee plants too.
I quit smoking back in '73, but I loved it. I now think that there may be a way to smoke and it actually would be healthy for you. It would have to be organic and could only smoke one cig after each meal or some other protocol . Anyways, this is a story of how greedy folks can take a good thing and make it into a bad thing. Hope this makes you think.
====OLE ROBERT HENRY==========
Up The Creek In Wv, Usa
Northland, New Zealand
Up The Creek, Usa
I'm looking for some insight into why this would have happened. My mother-in-law has Alzheimer's. She injured herself in a fall and got a steroid shot. The next day we noticed a significant change in her function, it was almost as if she had reverted back to the beginning stages of 5-6 years ago, an amazing improvement.
Now we are digging deeper to figure out why this would be - any thoughts? Nothing else changed except the shot, no drugs, no diet, nothing else.
Any insight would be extremely appreciated. We would like her to not revert back, if at all possible.
Ten Mile, Tn.
For anyone out there that wants to do something that works!!! I recently took care of a person with Alzheimer's when I first started helping she just stared ito space when you tried to converse all you could get her to say was "I don't know" started her on 1000mcg of vit D a day and 4-8oz of juice which is a mix of veg and fruit the strawberry/bannana flavor. Change began in less than a week she went from not knowing people unable to take care of herself etc.... To trying to do things for herself/ having meaningful/remanicent conversations with her spouse with in 2 months!!! If you have someone you love with this affliction try this it might not work as well on all I don't know but I have experieced it working on her!!! Oh yea take away all the useless alzhimer meds and traqulizers (only use for emerg behaviors that can't be talked thru) God bless you all.
Fairfax, Va, USA
New Jersey, US
It's been shown that alzheimer's is caused by the build-up of beta amyloid plaque, which are abnormally formed proteins. These plaques are in turn believed to be caused by small (also abnormal) fragments of amyloid precursor proteins (APP). These fragments result when a signaling protein on the cell's surface is cleaved incorrectly by various enzymes. It's been shown that vitamin E can reduce the presence of these APP fragments and protect brain neurons from glutamate toxicity. It's important to take a "natural" vitamin E source. It's been shown that the alpha, gamma, delta, etc.. forms all exert an effect.
Selenium is also an important factor, all alzheimer's patients tested had low levels of selenium.
Most noteworthy is that pigs get a "form" of alzheimer's called encephalomalacia and the historic vetrinary treatment was vitamin E and selenium. Encephalomalacia in pigs is generally associated with a virus, but that may be a result of deficient levels of selenium, an extremely important mineral for the immune system.
Dosage: Vitamin E 1500iu daily, Selenium 400mcg daily.
400mcg is approx 330% of the RDA, and 1500 IU is about 5000% of the RDA. They are both safe at these dosages. Megadosing with vitamin E was only found to be problematic when supplementing with just one form. When the various forms alpha, gamma, delta... of vitamin E are taken together in fairly large dosages there are only benefits.
Take a good multivitamin/mineral supplement (the best and most complete you can find) along with the vitamin E and selenium.
White River Jct, Vermont