I've been using MSM for several years and it works. First started with DMSO but my wife and friends couldn't take the Sulphur smell. Switched to MSM to 2 tablespoons a day and got ALL the symptoms of detox; headaches, change in heart rhythm, extreme fatigue, etc. Didn't panic and lowered the dosage. All the problems gradually disappeared. I take 2 tablespoons in powder form with powered Vit C first thing in the morning with around 16 oz of water. Then my bladder get's filled every 20 minutes... Constantly urinating clear. By late morning everything's good.