Luteolin is a flavonoid in various fruits and vegetables, including celery, parsley, thyme, artichokes, and carrots. It has been studied for its potential health benefits, particularly its anti-inflammatory and antioxidant effects.
In this article, we will discuss the health benefits of luteolin, the recommended dosing, potential side effects, and its use in skin cancer.
Health Benefits of Luteolin
Here are some of the potential health benefits of luteolin:
- Anti-inflammatory effects
- Antioxidant effects
- Anti-cancer effects
- Neuroprotective effects
- Cardiovascular benefits
- Anti-diabetic effects
- Anti-microbial effects
- Allergy relief
- Improves cognitive function
- Potential benefits for skin health
Luteolin has been shown to have potent anti-inflammatory effects by inhibiting the production of pro-inflammatory cytokines and chemokines. This may help reduce inflammation in the body and may be beneficial in treating inflammatory diseases such as arthritis. 1, 2
Luteolin is a potent antioxidant that can help protect cells from oxidative damage caused by free radicals. This may help reduce the risk of chronic diseases such as cancer and cardiovascular disease. 3, 4
Luteolin has been shown to have anti-cancer effects by inhibiting the growth of cancer cells and inducing apoptosis (programmed cell death) in cancer cells. Studies have also shown that luteolin may help reduce the risk of certain types of cancer, including breast, colon, and prostate cancer. 5, 6
Luteolin for Skin Cancer
There is limited research on the use of luteolin for skin cancer. However, a study published in the Journal of Investigative Dermatology in 2011 found that luteolin inhibited the growth of melanoma cells and induced apoptosis in these cells. Another study published in the same journal in 2013 found that luteolin inhibited the growth of basal cell carcinoma cells and induced apoptosis in these cells.
While these studies are promising, more research is needed to determine the potential benefits of luteolin for skin cancer.
Luteolin has been shown to have neuroprotective effects by reducing oxidative stress and inflammation in the brain. This may help reduce the risk of neurodegenerative diseases such as Alzheimer's and Parkinson's. 7, 8
There is no established recommended dosing for luteolin, as most of the studies have used different dosages. However, most studies have used doses ranging from 100-500 mg per day.
Potential Side Effects
Luteolin is generally safe when consumed in food. However, there is limited information on the safety of luteolin supplements. Some studies have reported minor side effects such as digestive upset, headache, and rash. It is important to consult a healthcare provider before starting any supplement regimen, especially if you are pregnant or breastfeeding.
In conclusion, luteolin is a natural flavonoid found in various fruits and vegetables that has been shown to have potent anti-inflammatory and antioxidant effects. It may also have potential benefits in treating and preventing cancer and neurodegenerative diseases. However, more research is needed to determine luteolin supplementation's potential benefits and risks.
It is important to consult a healthcare provider before starting any supplement regimen.
- Li et al. (2018) Luteolin suppresses inflammation through inhibiting cAMP-phosphodiesterases activity and expression of COX-2 and PGE2 in LPS-induced RAW264.7 cells. Journal of Functional Foods.
- Park et al. (2011) Anti-inflammatory effects of luteolin on lipopolysaccharide-induced inflammatory responses in RAW 264.7 macrophages. Biochemical and Biophysical Research Communications.
Lu et al. (2019) Luteolin exerts antioxidant effects on liver cancer cells and inhibits mitochondrial dysfunction through the ERK1/2-Nrf2 pathway. BioFactors.
Wu et al. (2019) Luteolin alleviates oxidative stress and cardiomyocyte apoptosis in diabetic cardiomyopathy via Nrf2-mediated signaling pathway. Journal of Cellular Physiology.
Zhang et al. (2019) Luteolin inhibits breast cancer development and progression in vitro and in vivo by suppressing notch signaling and regulating cell cycle and apoptosis-associated genes. Journal of Cellular Physiology.
Cao et al. (2018) Luteolin inhibits lung metastasis, cell migration, and viability of triple-negative breast cancer cells. Journal of Functional Foods.
Xie et al. (2020) Luteolin protects dopaminergic neurons from inflammation-induced injury through inhibition of microglial activation. Neuroimmunomodulation.
Jiang et al. (2018) Luteolin attenuates inflammation by regulating AMPK/NF-κB signaling pathway in BV2 microglial cells. Current Topics in Medicinal Chemistry.