My Chorkie had a horrible reaction to his Rabies/portadello...almost lost him! Living 5 miles from the vet I was just blocks from our home when max started FLIPPING all over the floor of the car. My first reaction was that his harness was pinching him. I pulled over, removed the harness, and at that time he started struggling with his breathing... His tongue was hanging out and he just went limp. I ran into the house (carrying this little 6 lb. Dog who is having a hard time breathing) called the vet and they told me to get him back out there quickly! Now his face is swelling and he is really gasping for air as we get back to the vets. They gave him a pill because they were afraid to give him another shot! I've never gone back for is booster.