So glad I found this page! Our dog came down with closed pyometra last week during her heat. She went down quick. Not our normal Coco. We have never heard her cry or yelp but when she tried getting up 3 different times last week she cried. I stopped at a natural food store after reading this article and purchased some Manuka Doctor +24 and we ordered Vitamin C for dogs. The first 3 days we didn't have anything. The vet hospital was going to charge $3800. We didn't have it and thought we may have to put her down. Coco is 10 years old and a boxer/mastiff mix. It hurt us to see her look at us like, "help me daddy & mommy." We started giving her the mix and she is slowly coming back. Much improvement has been made. She will see the vet next week and hopefully he'll give her antibiotics to help clear this up. As soon as this happens, she will be spayed. If anyone lives near Richmond, VA there is a place that does the surgery for $455.00. They don't believe in charging families all of that money and don't want us to have to choose between bills and an animal. Thank you all for your encouraging stories. Praying for all dogs that are going through this!