Natural Remedies for Cushing's Disease in Dogs

| Modified on Oct 26, 2023

Cushing's disease, also known as hyperadrenocorticism, is a condition in dogs characterized by the overproduction of cortisol, a stress hormone. This can lead to various symptoms, including increased thirst, urination, hunger, and a pot-bellied appearance.

While several pharmaceutical interventions exist for this disease, many dog owners and veterinarians are exploring natural remedies to complement or replace traditional treatments. Here, we delve into the research surrounding natural remedies for Cushing's disease in dogs and spotlight the most promising supplements.

1. Melatonin

Melatonin is a hormone naturally produced in the body that plays a role in sleep-wake cycles. Some studies suggest that melatonin can benefit dogs with Cushing's disease.

How it works: Melatonin may inhibit some of the enzymes required for cortisol production, helping reduce its levels.

Research findings: Some small-scale studies and anecdotal reports suggest improvement in symptoms with melatonin supplementation, though larger, controlled trials are needed.

2. Flaxseed Lignans

Flaxseed contains compounds known as lignans, which have demonstrated potential in managing Cushing's disease in dogs.

How it works: Lignans from flaxseed, particularly secoisolariciresinol diglucoside (SDG), may act as cortisol enzyme inhibitors, reducing cortisol production in the adrenal glands.

Research findings: Preliminary research has shown promise with lignan supplementation, with some dogs experiencing reduced symptoms. As with melatonin, more extensive studies are required for definitive conclusions.

3. HMR Lignans

HMR lignans are another type of lignan derived from the Norway spruce tree. They are often mentioned alongside flaxseed lignans for Cushing's treatment.

How it works: Similar to flaxseed lignans, HMR lignans may inhibit enzymes involved in cortisol synthesis.

Research findings: Some canine studies have shown symptom reduction with HMR lignan supplementation, but again, larger-scale trials are essential for a clear understanding.

4. Ashwagandha

Ashwagandha is an ancient herb with adaptogenic properties. It is often explored for its potential benefits in various conditions, including Cushing's.

How it works: As an adaptogen, ashwagandha might help balance cortisol levels by modulating the adrenal function.

Research findings: While ashwagandha is well-researched in other contexts, its use for Cushing's in dogs is still in preliminary stages. Anecdotal reports indicate potential benefits, but scientific validation is needed.

5. Dandelion Root

Historically used for a variety of ailments, dandelion root is believed to support liver and gallbladder function, both of which are crucial for hormonal balance.

How it works: The root may aid in detoxifying the liver, helping to regulate cortisol levels.

6. Milk Thistle

Another herb known for its liver-supporting properties, milk thistle, is sometimes recommended for dogs with Cushing's disease.

How it works: The active compound in milk thistle, silymarin, might help in liver detoxification, possibly affecting cortisol regulation indirectly.

7. Turmeric (Curcumin)

This golden spice, commonly used in cooking, possesses anti-inflammatory properties. Curcumin, the primary compound in turmeric, has been researched for various health benefits.

How it works: Curcumin's anti-inflammatory properties may help in reducing the inflammation linked with high cortisol levels, potentially benefiting dogs with Cushing's disease.

8. Bilberry Extract

Often praised for its potential eye health benefits, bilberry is another supplement occasionally explored for Cushing's.

How it works: Bilberries contain strong antioxidants, which might support overall health and assist in the balance of various bodily functions, possibly including cortisol regulation.

Research findings: There's anecdotal evidence supporting its use, but rigorous scientific investigations are still pending.


While the quest for natural remedies for Cushing's disease in dogs continues, the above supplements have garnered attention due to promising preliminary results. It's vital to remember that while natural remedies may offer hope, they should not replace veterinarian-prescribed treatments without proper consultation. Always work closely with a vet when considering any new treatment or supplement for your furry friend.

Below, explore various home and natural remedies for dogs with Cushing's disease, as our readers recommend. Many have found success using melatonin, flaxseed, homeopathic Cushex drops, and certain Chinese herbs.

If you've tried any remedies for Cushing's syndrome or know of one not mentioned here, we'd love to hear your experience.

Diagnosing Cushing's Disease

Posted by Jimb (Greensboro, Nc) on 06/17/2016

Our 12 year old cockapoo was just diagnosed with Cushings. We had noticed a thinning coat and reluctance to go on walks, but an episode of imbalance/vertigo/nystagmus in which I rushed her to the emergency vet has led us to this conclusion. The emergency vet suspected a random vestibular event, but elevated liver enzyme made her suspicious. Suzy's regular vet confirmed Cushings via blood test, and we're going today for a belly ultrasound. We're hoping to be able to manage her condition without harsh drugs. I'm grateful to have found this website, and appreciate reading everyone's experiences. Anybody with words of wisdom as to how to relax and be at peace with all this, please chime in! Thanks.

Replied by Bert

My 14 1/2 yr old Rat-ShihTzu was diagnosed on 6/8/2016 with Cushings. She is taking Rehmannia 11 (Chinese Herbs), Livaplex, A-F Betafood, Cardioplus, for this. She is also in congestive heart failure diagnosed last week. For that, she is taking Lasix and Benazepril. She developed a cough which brought us to this new diagnosis.

Since taking the Cushings medicine her kidney function is back in the normal range and the liver enzymes are coming down. This is really hard and I hate that she is going through this. I don't know how long this will continue but as long as she is eating well and continues to interact, we will carry on.

The heart failure issue is slightly improved but the cough is still there. That is my biggest concern. Please let me know of your progress with Suzy as I think we are on the same timeline.

Chloe also has dental issues but until we can get her stable, we can't anesthetize her for the extraction/cleaning. She has been a healthy dog for all of her life until now. It breaks my heart. Take care and I hope Suzy is doing well.

Replied by Donna
(Andrews, Nc)

I have three cockapoos...One had three episodes of pancreatitis, then kidney failure after seizure and moaned a whole day even on MEDS and IV's and put him down...He was my doggie soul la et 16 years. NOW ..I have two dogs with probable Cushings..panting, weight gain, thirst and urinating....One had nystagmus and at that time no mentioned Cushings...It has been years and finally this diagnosis! I am angry both went so long with just old age syndrome..The first mentioned sixteen and these two 13yo and 15yo..I am also not doing stress steroid tests..and will do organis low fat diets and supplements. I chose Pet Well Being Adrenal Harmony Gold..and waiting for it in the mail and did kidney support supplements weeks as one had elevated BUN....and a kidney diet..ALL so expensive...!!! BUT want the every best! IT is frustrating to have two with possibly same diagnosis! OUR prayers for all fur baby pooches struggling and pet owners!


My now 14 and half year old dog was diagnosed with Cushings from her yearly Wellness exam a year ago. She did not show any symptoms at first, but when she did the Vet prescribed Trilastane. We monkeyed around with changing dosages and time of day administering and she seemed to just keep getting sicker. The potential side effects of the meds are the same as some the the symptoms of the disease so I had no idea what I was dealing with. After about 3 months of this my gut finally told me to take her off the meds and in the meantime I had been researching alternatives.

Follow your vet's advice on how to take her of these meds. It has to be done gradually.I started her on Pet Wellness Adrenal Gold Harmony and she is doing great! It contains turmeric and milk thistle as well as other plant based elements. She now has a bit of a spring to her step and a renewed sparkle in her eyes and although she still cannot make it through the night without pottying (heck, I can't either). We just use potty pads for her. I am so happy with how she is doing I would recommend Gold Harmony is anyone that has a dog with Cushing's.

Replied by Diana
(Raleigh, North Carolina)

Hi, where did you get the Rehmannia 11 (Chinese Herbs), Livaplex, A-F Betafood, Cardioplus?

Replied by Tallone781
(St. Petersburg Florida)

Does anyone have any natural treatments for Cushing's disease from a pituitary adenoma?

Dietary Changes

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Posted by Gayle (San Jose, Ca Usa) on 09/20/2012

My dog came down with Cushings about 1 yr ago. Decided against standard treatment because of side effects, cost, and the fact that the drugs start killing off the adrenal gland. Switched to diet that is blend of EVO wet food, raw meat, raw eggs, cottage cheese, yogurt, raw vegetables, raw fruit, and a supplement the vet had called Si Maio San 4 Marvels by Kan Essentials. After 4 days his symptoms completely stopped. I think the diet made the difference. Just recently the symptom of increased hunger has returned and I'm going to switch to mostly raw to see if that helps. I'm also going to add the probiotics and ACV.

Dietary Changes
Posted by Cinde (St. Petersburg, Florida) on 08/26/2009

This is quite a long story, but since not much is published on the Cushing's link for Dogs, I wanted to add what happened to my Yorkie, Nikki. She is not cured and still has set backs, but initially she did a complete 360!! She was very sick and the "reg" vets wanted to put her on massive steroids, my groomer recomended a Holistic vet, on our first visit she informed me we could just about cure Nikki's Cushings with proper diet, supplements, etc. It was one of the most thorough examinations she ever had. She was also shocked at all the drugs my dog had been given throughout the first 5 years of her life. She had seen 7 specialists up to this point. Holistic vets are very expensive so maybe I can help by sharing our daily regimen and what the Dr. first did for her.

1) No more chemicals, ie: flea control products

2) No more grains or canned dog food, dogs are carnivores, period.

3) No more vaccinations, they are supposed to only be administered to healthy animals only, She checks the animals titers and Nikki still had plenty of Rabies titers even 2 years after her last one, only other one she reccomended was Bortadella, Nikki still had some in her blood after her last one of 3 years ago and she only recommends it for dogs who go to dogparks or are around other dogs, Nikki does not. You can be issued an exempt form from your vet for your county animal control that dog is to sick to administer rabies, etc. an exempt form must by law be accepted and your licenses not held up.

There is a lot more to tell you but got to take a break.Will be back to finish, will copy in my email and save so I can finish, but will go ahead and post this for now. I will be back with what she takes, what she eats and what has occurred over the last 2 years since all this. Godbless, Cinde

Replied by Stella's Mom

First, ANY animal or person with ANY health condition, illness, disease is NEVER to be vaccinated again - not bordatella, rabies, whatever. None means 0, nada, nothing. The vet who advised you about giving bordatella is wrong; it also is a useless vaccine and only helps with 2 of the 8-12 types of "cold" your dog could catch. Best is to make their immune strong and healthy. That happens by feeding the right diet of raw meat and bones, a little vegetable, good fat (meat, eggs, salmon..), NO vaccines/drugs/toxins/chemicals. No grains; dog's are carnivores. They don't cook and don't eat grains of any kind.

Our family uses homeopathy for ourselves and our animals. No matter what the condition, homeopathy can and does cure - not cover up the symptoms or make another problem. We've used it for dogs with liver disease, seizures, IBD, pancreatitis and aggression (caused by rabies vaccine). It's been successful for each.

Replied by Jan
(New Port Richey, Fl)

Hi Stella's mom, my 12 1/2 yr old beagle has cushings. Just today I talked w/her Vet and we agreed to begin selegine on Monday. Can you tell me exactly what raw diet you have your sweet Stella on? I used to make my own dog food by cooking chicken, green beans, carrots, applesauce, sometimes rice, sometimes oatmeal. But Allie constantly had GI upset, diarrhea, mucousy stool. Have her on Science Diet ID now, canned which she is tolerating well. But classic cushings (hunger, thirst, increased urination, lethargy, sagging belly, nighttime restlessness, incessant barking). Have been doing Denamarin (S-AMe and milk thistle) for 3 1/2 years which made a world of difference for awhile but things have advanced and adding selegine. Allie is also mostly blind and deaf as far as I can tell and this is new for the past 2-3 months.

Any advice, tips, etc from you or anyone is greatly appreciated. Also interested in the supraglan and anipryl, will look them up as alternatives to selegine.

Replied by marty

Hi Cinde, I can tell you are a passionate dog lover so am I. We all need each other in this world of lies. I just want to challenge your statement >>>>>>>>>dogs are carnivores, period.

After researching many experts that I follow, I believe, cats are carnivores and dogs are omnivores.

Therefore they need fruit and veggies, mostly with some meat. Let me know if after you check it out you still feel they are carnivores. Have a beautiful day, Marty

(Orlando, FL)

Thanks for the insight that dogs are omnivores. I used to live on a farm with five rescued dogs. They would eat apples that had fallen off the trees. Daintily pick blackberries off the vine in summer. And steal cucumbers from my garden to eat. And they willingly ate carrots as treats. So, I agree.

(Illinois, USA)
489 posts

Dogs are carnivores BUT if they're not getting meat and bone, they'll eat just about anything in an attempt to get the nutrients they're not getting or that their body can't manufacture because they're not getting meat and bone because they're basically starving. Most life forms will. But don't feed them rabbit. The only food in rabbit is in the head. People often find decapitated baby rabbits in their yards and think they must have been hit with the lawn mower but if their burrow is raided, the raiders only eat the heads.

Chicken thighs are good and cheap. Skin and all but with only 1/3 of what's fed with the bones - the rest boneless. Too much bone too early will bind them up. They need to go through the "cleanse" stage before they're fed whole chickens, necks or other bony parts.

A raw fed dog will not dig in the garbage or beg at the table for people food. They're getting what they need so there's no need to forage for nutrients.

Dietary Changes, Remedies

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Posted by Maren (Minneapolis, Mn) on 11/15/2009

My dog with cushing disease went from almost being put to sleep to almost normal again. He had cough every 15 mins, skin rashes, over drinking water, over eating, blood nose, siezures and started to go to the bathroom on the carpet. The first thing is no rice, grain, barley or canned food. Too much toxin effect the cortisol causing the cushing disease. Had to invest some time into what may work. I went to all organic sweet potatoes and fish by Wellness, mixed with pumpkin, baby carrot organic, milk thistle(liver clease) apple cider vingar organic only, cap full to each meal, enzyme for digestion (very important) and probotic (acidollius)( very important), little olive oil (1/2 tsps to a meal) and dog vitamin pill. I found that getting all the ingredients together and mix in a blender, and refrigerate. Making up the foods ahead is how to win the battle of time to make each meal. I make enough for about 5 days, this is make sure it does not get stale. Use canned pumkin with the ingredient just pumkin or sqaush. Carefully not to give too much of this will spike the blood sugar level in the body. I use natural product to it is 1 drop per 2 lb of weight of dog. His eyes were no long blue in the waters. His tumor in the nose stop bleeding, he seen to breath better. I first did the transition for the dry food, to wet dog food, to a mixture, now all organic. This the key toxin in the dog as they get older cannot not keep up. Your dog and yourself do not have to suffer anymore. It is less expensive in the long run and a better for ourselves. Do not give up on your dog until organix.

Thank you, owner myself with dog with cushing disease.

Replied by Erica
(Goodlettsville, Tn, Usa)

My dog has high liver enzymes ALT and ALP. The enzymes are elevating each month. I have had pleanty of blood work done and have put her on the diet the vet reccommended and she is taking a daily supplement with milk thistle in it. Can you recommend a more natural diet? I have read articles and just am worried sick about my dog. he is 16 and I dont want to do surgeries or anything where she has to be put to sleep anymore. Can you help me? Thank you. Erica

Replied by Meeasm
(S. Ontario, Canada)

Suggest seriously perusing info on Mary Strauss' website at WWW.DOGAWARE.COM

and/or joining Lew Olsen's K9Nutrition list on yahoo. com at K9Nutrition group

Wishing you the very best of luck and am sending zen, healing thoughts and prayer to you both!

Replied by Clondon
(Lakewood, Ca)

I would switch to raw feeding you can buy pre made raw if you don't want to do it yourself!

Replied by Tina
(Lancaster, Ohio)

Solaray Milk Thistle with Phytosome 80% Silymarin 300 mg. 1x a day, Solaray Tumeric Root Extract 95% Curcumin 300 mg. 1x a day, Nature Made Fish Oil 1200 mg. W/ 360 mg. OMEGA-3, NOW SAMe 200 mg. 1-2 x's a day on an empty stomach. I also give Pet Probiotics and Enzymes by Dr. Mercola Healthy Pets. My Dallas has very high ALP liver enzymes (3, 971) off the charts and they have been going up for the past two years until I put him on Milk Thistle and Tumeric combined w/ the other supplements. In 3 months time I have got his liver enzymes down to 2,300 and still working to get them down. I will have the vet recheck in a few months to see were the ALP enzymes are at. I have also put him on a Raw food diet (Nature's Variety, Instinct raw Bites). No grains at all. He is possibly a Cushing's dog. Oh and his weight is 26-27 lbs. I hope this helps and the best of luck.

Replied by Diana
(Ca., US)

Stay away from commercial foods all around and canned vegetables, pumpkin or anything else that comes in a can. Use Halshan raw food rabbit and vegetables or fish and vegetables and cook in a pot and portion before freezing. Use Dogtorx twice a day. The product has a new name now since it is new branding. Emeric is manufacturing it. Don't overload your dog with continuous digestive enzymes until he won't be able to digest properly without them. A wonderful supplement one should not miss out on is mezotrace special dog formula.

Replied by Jr Denman

You can get organic pumpkin (no other ingredients or preservatives) in a BPA-free can at Whole Foods. It's called "Nummy-Tum-Tum" and made just for dogs. I've never found frozen pumpkin, and fresh isn't always available and is difficult to handle. Pumpkin is very good for a dog's digestion.

Replied by Leslie
(Tampa, Fl)

My dog was diagnosed today with Cushings after the low dex test was done this week.. I use integrative medicine.. & do not have an integrative vet in Tampa. I did want to thank Jr Denman for his pumpkin comment with the product from Whole Foods.. I am just starting this journey to treat my dog with the best combination of products.. I hope to find a vet that can work with me .. My vet only has a negative opinion about the holistic treatments. She says no studies show that they truly work..

I love the info from University of Tenn. College of Veterinary Med. & am going to order a product called Cush Away..

Anyone use that product?

Replied by Carolyn
(Hudson, Fl)

I tried using pumpkin and my dog, 8 yr old lab mix, had horrible runs. I stopped the pumpkin and it cleared up. Good luck.


Use sweet potatoes or yams instead of pumpkin.

Replied by Wendy

You more than likely used far too MUCH canned pumpkin.

Read this info:

"Too much canned pumpkin can lead to lose bowel movements and create an entirely different issue."

Also, make sure you're using PURE PUMPKIN, NOT the pumpkin pie filling!

Replied by Jan
(New Port Richey, Fl)

Hi there, I am in the Tampa Bay area as well, recently moved to NPR. Dr. Carmen Saladino was formerly with Connechusetts Animal Hospital and is now at Animal Care in Land O Lakes; she's been my vet for > 20 years w/2 Cushings dogs. She recommended Denamarin for my beagle and it's made a great difference. Now 3 years later, we are looking at adding selegine, but from this website I'm going to look at Cushex and raw diet. If you look Dr. Saladino up tell her Allie's mom sent you; her number is 813-996-3800. Grateful for this networking website. Best of luck to you.

Replied by Christine

What is this in your article "I use natural product to it is 1 drop per 2 lb of weight of dog." What kind of drops is it. Now that it has been several years how are your dogs doing?

Replied by Dee

Where can I dogtorx. No one seems to sell it.

Dietary Changes, Supplements

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Posted by Dr. Bee (Atlanta, Georgia) on 12/16/2016

My blue pit developed cushings and it became horrible before diagnosis. He started losing his hair and developing sores on his body. I am Naturopath so I immediately removed his food and started giving him fish, sweet potatoes, balck rice, irish moss, moringa, and other herbs for his red blood and immune system. His symptoms have cleared up except I am still not satisfied with his skin. It has not properly healed and he carries this offensive odor. I realize with all healing it takes time but does anyone know what to use to minimize the odor coming from his skin while healing??

Replied by Deirdre
(Los Angeles, Ca)

Hi Dr. Bee. So sorry to hear your dog has Cushing's Disease.

Have you done a T4 thyroid panel on your dog to see if he's hypothyroid? My dog had the same symptoms and I ordered a thyroid panel. My vet then suggested ordering a T4 after seeing the results. Turns out he was hypothyroid. A few weeks after starting him on thyroid meds his fur starting growing back and the odor was gone.

Replied by Debra
(Houston, Tx)

You could try human probiotics like acidophilus.

Grain-Free Diet

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Posted by Tom (Vallejo, Ca) on 08/22/2015

Switched my dog to a grain free diet and it help out on the Cushings disease. His overall improvement was 90 per cent.Still has minor hair loss and a small cough once or twice a week instead of daily.

Homeopathic Drops

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Posted by Jan (W. Ma, USA) on 09/27/2009

My 10-year-old Tibetan Spaniel developed Cushings. I looked into holistic treatments and found Cushex drops containing: Taraxacum officinale, Arctium lappa, Astragalus membranaceous, Arsenicum (30C), Hepar. sulph. (30C), Mercurius (30C), and sulphur (30C). I use 3-4 drops on his food, which also includes raw frozen chicken or beef, home-made plain yogurt and canned pumpkin. Within two weeks his appetite was level, he greatly reduced his constant gulping of water, his coat grew back and his energy level and mood are fantastic.

Now that he's been on the drops for a while, I cut back to every-other-day for the drops for maintenance.

Replied by Sue Tay
(Oregon, US)

I also used Cushex drops for my American Eskimo who was diagnosed with Cushings at age 12. At the time his liver enzymes were so elevated the vet didn't know why he was still alive. He was panting heavily, barking at phantom food he thought was on the table, pacing a lot at night (which may have been the start of canine dementia) and very thirsty. The treatment the vet mentioned was super expensive with all the testing that was involved. I put him on Cushex, 3 times a day at first, then 2, then after a while just once. The bottle cost $30 and lasted a year. I went through 3 bottles and then his symptoms did not reappear. ( A year earlier when I ran out and couldn't get another for a couple of weeks they did reappear, but less.) My little guy passed away a month before he turned 16. So glad I had that extra time with him!

Replied by Darlene
(Virginia, USA)

My dog has Cushings and I appreciate all the info on this site! I have a question:

I am interested in changing our dog's diet to raw like you talk about. The problem is that I'm vegan - I don't know which meat to buy, and I don't know about the yogurt. What do you buy? Where do you buy it? Can I use store-bought yogurt?

Replied by Theresa
(Mpls., Mn)

Hey Darlene!

You are posting on a thread from 2009; in case the original poster does not see your question, I have some advice.

If you are vegan you might find it easiest to use a pre-formulated raw diet; these are located in the freezer section of higher quality pet supply stores. Also, rather than yoghurt for the probiotics, you can also buy these in capsules in the refrigerated section of high quality HUMAN health food stores; you might also consider home made raw sauer kraut for the same probiotic health benefits.

Replied by Ana
15 posts

Use Dr Pitcairn and Dobias, they are 2 separate DVMs for their websites, videos and books. We have used one day of veggie broth, 3x a day, as much as the pup/dog will take, homemade and no salt, then next day use chicken juice, from uncooked chicken and just boil enough until it just turns color. Next day 1 cooked egg in am, leave runny, then in pm chicken cutlet, used breast. All other meats rotate except beef, do not use, use chicken, turkey, lamb pork, deer, rabbit, fish, see Pitcairn for recipes and Dobias has good input on why certain meats. Real bones are only done after a couple of weeks with success here and they are never ever cooked. I start holding the chicken leg for example and teach the dog what I expect and eventually they get the idea real fast to use all their teeth. You must provide a place for them to eat that is easy to clean, also get gentle soap to wash their jaw/chin and paw areas, use like Dr Bonner or Dr Woods soap watered down. Start with part-cooking your meat and keep track of any issues along with what you feed to rule out allergies. Use cast iron pan and cold pressed olive oil. Herbs and spices are okay see the above doctors for more info. You will see the spices used in their practice and supplements, like parsley, Italian spices with no onion, only use garlic powder in small quantities. Hope this helps. Apple cider vinegar should be a regular in your kitchen, research everything and keep track, in the end it is easier, cheaper and you will have wished you had done it long ago.

Prayers and best of the best to you and yours.

Replied by Dee

I buy organic plain whole yogurt and also use organic plain whole kefir for my dog.


Replied by Edna

I am curious how many drops you use of Cushex?

Replied by Linda

My boxer has cushings. It is a very frustrating disease. Where did you get your drops?

Replied by Diane

Dogs do not eat sauerkraut. They don't even have a need for much in the way of veggies.

Replied by Theresa
(Mpls., Mn)

Hey Diane,

My dogs LOVE sauerkraut! And the non-pasturized types provide beneficial probiotics.

Replied by Ccmolly74
(Akron Ohio)

My name is Caren. I have a 10 yr old female shih tzu named Molly and she has been diagnosed with Cushings disease and I saw that they said that they use melatonin for her Cushings she weights 16 pounds and was just wondering how much melatonin to give her?

Melatonin and Flaxseed

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Posted by Nivia (New York) on 11/06/2017

I would like to share information about The University Of Tennesse Veterinary... my dog was diagnosis with Cushing in 2011 when she was 7 years old she is now 14 years old and has been stable since. The products they mention on their website was effective on my dog.

The flax seed hull(Lignan)SDG by lignans for life and Melatonin for dogs 3 mg once a day depending on weight. I also believe it has been a big contribution to her health not worsening. I must say not every Veterinarian will have anything positive to say when it comes to Holistic medicine and not every animal will have the same results.

You have to use your own judgement along with changing her diet with raw foods, 100 percent coconut virgin oil in her foods and pro-biotic and digestive enzymes, omega oil will help with her skin and coat and digestive system. When I first change my dog's diet she did have a loose bowel movement, add 1 Tbs of coconut oil pure virgin and omega oil her body eventually got used to the change and her loose bowel movement stop it was a matter of her system getting used too. Always, check ingredient's on supplements that it mostly has natural ingredients. If you question any ingredients on a product do research on the product. I hope this can at least give you some idea what direction you would like to approach. I am not an expert or a Veterinarian I'm sharing my dog's experience with you in the hope this may help in some way or another. Good luck!

Melatonin and Flaxseed
Posted by Kim (Arizona) on 12/20/2016

We have a boxer with a very tough case of cushings with a horrible case of calcinosis cutis. That is the open sores. We tried the natural route and saw very slight improvement. I stumbled upon study done at a university in Tennessee that uses melatonin and lignans. The melatonin actually grew all her hair back from a completely bald start. Her sores were lessed. Check it out easy to find information on it. And best of luck, cushings is a really rough one.

Replied by Jacqueline
(Bonney Lake)

Hi Kim, how long did it take for the fur to grow back? My girl was also diagnosed with atypical Cushings from U of Tennessee. I've been using Dr. Mercolas hormone support which contains melatonin and lignans from Norway spruce, for about 2 months now.

Replied by Robin

Jacqueline, has your dog improved using Dr. Mercola's hormone support?? I know you said it's only been a couple of months so you probably haven't had any blood tests since using the hormone support? To know if the blood values are any better?

Melatonin and Flaxseed
Posted by Debbie (Va) on 09/27/2016

I make pancakes with flax for my dog with cushing. I use flax, pumpkin and water. She loves them and it has greatly reduced her symptoms. I make up a large batch and freeze them so I dont have to make them often. I give her one in the morning and evening. Also give her melatonin.

Replied by Laura

Thanks for the suggestion, my little dog has been diagnosed with cushings and the treatment is not working so I want to try the natural remedies, I tried to find a recipe for the flaxseed and pumpkin pancakes but no success, could you share the recipe? my dog weighs 9 pounds and I was wondering how much flaxseed should I use and if the are cooked or raw. I would really appreciate it if you would share the recipe.

Replied by Cindy B.

I am just learning about Cushings - and I believe my 11 year old havenese Bella has the disease. The et has not been real encouraging to test her, as the Tests they say are inclusive. I want to start her on Flax and Pumpkin pancakes - can you share the recipe with me? Also, do you use melatonin? Thanks for your help! Cindy

Multiple Remedies

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Posted by Dee (Charleston, Sc) on 08/06/2016

I have a 10 yr. old Shih Tzu dog with all the Cushings Disease symptoms. He is on a grain free diet, only eats chicken, lamb, rabbit, fish. I add a little yam or pumpkin, kefir, cold pressed virgin olive oil or org. virgin coconut oil to his food. Every 2 days I give him vitamin E and 1/8 tsp. Kelp powder. Turkey and Beef gives him gas. I tried the Cushex drops and Seriphos and they did not work on him.

I do give him Olive Leaf, Milk Thistle, Lignans for Life Lignans flaxseed, and Melatonin. It helped his fur grow back, his excessive water drinking is less, his weak back legs are better, he pants less at night. The only symptoms that he still has is excessive hunger from noon till evening, and restless at night. He sleeps during the day and restless most of the night. My guess is his cortisol is high at night.

Does anyone know a remedy for hunger and to help my dog to sleep at night?

Replied by Maribethp
(Denver Pa)

According to Chinese medicine a Cushings dog should not eat chicken because chicken produces heat. Fish, duck, pork, beef better

Replied by Lori

My Shi Tsu had this also (he passed from it last year). I don't know of anything to cure the hunger, I used all the stuff you listed also but I also added blended frozen cranberries into his food for the vitamin C and gave him melatonin right before bed which usually helped him relax? (some good nights and some bad nights ).

Multiple Remedies
Posted by Debbiemarie54 (Loma Linda, California) on 07/24/2015

This is my first post. My dog Cody, who is 13 years old, and a Sheltie, was diagnosed with a very mild form of Cushing disease. I opted to not place him on traditional medicine and try Cushex Drop S. Cody has been on the drops about 1 month. His appetite is normal again and he does not pant as much as he used too.

I think his hair may be returning but I'm not sure yet. I had him shaved due to the heat last summer, and his hair never grew back. That was before the diagnosis.

I give Cody 5 drops in his food in the morning. He is 48 pounds. Is that the correct amount?

Another problem I have with him is he constantly licks his feet and injures himself to the extent I have to take him to the Vet, make him wear the cone hat most of the time, etc. And Cody seem anxious a lot, which makes me anxious because I don't know how to soothe him.

I recently put him on Pet-Eez from PetsMart as a last resort. I am on social security and really cannot afford these high Vet bills, expensive medications, etc.

Any suggestions would be appreciated.

Replied by Debbiemarie54
(Loma Linda, California)

Can someone tell me the correct dose of the Cushx- Drops-S to give my dog Cody? I asked this in an earlier post but really didn't a response. He is 48 pounds with a very mild case of Cushings Disease.

I opted for the natural method due to the cost of the traditional method and because he only has a mild case.

Someone earlier suggested I place him on an elaborate diet. This is out of the question. I have major clinical depression and I barely cook for myself.

I love him and want to keep him as healthy as possible, but I am only capable of just so much.

Can someone please just tell about the dosage of the drops? Thank you.

Replied by Theresa
(Mpls., Mn)

Hey Debbiemarie54!

If you read the forum folks mention various dosages they used for their particular pet. Dosage may depend on weight or severity of symptoms, and may change depending on improvement or worsening of symptoms. Since you have purchased the product and have it in hand, what does it say for dosage information on the product itself?

I have not used this product and have no familiarity with it; if you need further guidance as to dosage and find no useful direction in reading others experiences, the company does offer support staff for questions - why don't you contact the company directly and speak with their experts? The number to phone a call in or submit an online request form can be found on the product website:

Good luck and please share what you find!

Replied by Erika
(Irvine, Ca)

Hi Debbiemarie54,

Re: "Cody constantly licks his feet is a major symptom of allergies."

My 7yr-old Yorkie does the same when she eats chicken, beef, Bison, turkey and lamb. I didn't know and was giving her all of the above mentioned for a long time. I used to think her licking her paws were her habits or something and didn't think much of it. One day, she had a severe allergy reaction, anaphylaxes after eating chicken soup I made, (just good chicken and carrots without salt.) and I found out that she has been allergic to chicken. Since then I paid more attention and found out she has also developed allergies to beef, bison, turkey and lamb. (after eating any of these she would start licking her paws in five min.)

I stopped giving her all of them and started to give her Pork and Venison and now she never licks her paws.

Please try feeding Cody a different type of protein, if you have been giving him chicken or beef or any of the mentioned above and see if he still licks his paws after he eats them. Because I've experienced the same myself I wanted to help. I understand how it is like. It's not easy. Ask me w/anything I'm happy to help you and Cody!

Replied by Diane
(Louisville, Ky)

Newton homeopathy. Fatigue fighter. Thyroid. No grain dog food. Venison sweet potato or buffalo sweet potato. Natural balance dog food. Classical music. No loud music or noise worked for us. Allergy and or stress problem. Keep everything less stress.

Replied by Paulette
(Omaha, Ne Usa)

I also use Cushex drops-S for my 15 yr old, 20 lb. American eski mix. The bottle will give you a recommendation for body weight. I use .25 on a small piece of bread 3x a day. Vet had me put her on 3mg of melatonin am and pm for her anxiety. He also said to give her 20 mg of HMR Lignans made from Norway Spruce that you can buy on Amazon. All these were approved and recommended by my vet who really doesn't do holistic but knows that I do for myself.

It is a very expensive disease to treat the traditional way with all the testing that needs to be done. Since there is no cure and the vet gave me the option of treating it traditionally or holistically, I chose the holistic approach and I am glad I did.

She still pants and is restless but eager for her meds. Doing much better and seems to be happy.

i use only grain free food, dry and moist from Only Natural Pet.

Replied by Nancy

Hi Cody's Mom,

Try some Chamomile tea. Start with weak (of course dilute with cold water) and gradually use more bags and longer steaping until he is used to stonger tea. Keep track of his water intake in case he doesn't drink enough!!!! But you may have to make the tea his only H20 source so he will drink it. Check on line all the stuff they say Chamomile will do. I've used it before and am part way into a regimen for our JRT, Snickers. Supposed to be good for anxiety, stress, upset anything. Can soak feet in it and let air dry for itching and licking. Hope you find a good solution! I know how frustrating and stressful it is when our best friend can't tell us what's wrong. Love, Nancy

Replied by Gregory

The chewing on the paws could be an allergic reaction to food. Mine did that. Scooted a lot and would lick into the air. Found out she is allergic to a lot of things and had to switch to raw food.

Replied by Harry C.
(Glassboro, NJ)

We are trying 1 1/2 mg melatonin and hmr lignans. Everything is priced right. Take a look. This is working for us

Multiple Remedies
Posted by Clare (England) on 08/16/2014

My GSD bitch has Cushing's and the vet wanted to start her on Vetoryl. I was so worried and read everything online about Cushing's, Vetoryl and alternative treatments. I tried flax lignans, a homeopathic remedy I read about online that an English vet had done a study on. I already feed raw. Anyway I clutched at any straw going. Also the Cushing's had effected her liver so she was prescribed a very expensive supplement which I can't afford and the insurance won't cover, so I imitate it with the ingredients bought seperately.

Her first stim test showed no improvement and I gave in and asked for Vetoryl. I took the week off from my part time job and never left my dog because I was so scared of side effects. Nothing happened and she has been fine on the Vetoryl. Her first stim test since she has been on Vetoryl shows that her Cushing's is under control and one of the liver enzymes is now just under the normal top range, and the other had dropped from 800 to 400, which is still high but on its way down. Hopefully the next stim test in a month will show the liver is back to normal.

My vet wanted me to use Hill's LD prescription diet instead of raw but no way am I feeding my dog soy. I think it is because she is fed raw that her symptoms have been mild and that she has responded to a low dose of Vetoryl The moral of this story is not to be afraid of Vetoryl. The only problem that has arisen is that because the high cortisol level masked her arthritis due to hip dysplasia she went very, very lame and refused to go for a walk. The vet has prescribed Onsior because the curcumin that helped my other GSD who also has HD so miraculously didn't help my bitch. Onsior has done wonders for her. Again I don't like using it as it is an NSAID but my vet assures me she will be fine. She is ten and if she has another year of life with no hip pain and her Cushing's under control that I will be happy.

Multiple Remedies
Posted by Tamarahsimone9 (Los Angeles, Ca) on 07/20/2014

I thought I would share my story about my 9 year old female dachshund. She weighs 18lbs, and was diagnosed with Cushings the end of April 14. She doesn't have all of the symptoms, however, she was coughing alot, and then got pnemonia. That is what has led me on this journey.

When her blood test came back positive for cushings, I immediatley went to a holistic Dr. He muscle tested her and gave me some supplements. She contracted pnemonia again. Dr. prescribed clavamox which got rid of the pnemonia. Since then, I have decided to treat her with supplements and organic food. The Dr. wanted to start her on meds, however, I really don't like the side effects. Plus, monthly blood work etc...which I would totally be willing to pay, however, I believe I need to try to heal her naturally.

So, here is my regime, it takes time each morning and evening, but, for what I am observing, her hair has grown back (she had a round patch of hair missing) the underside of her torso has also grown back completely, she's active, doesn't drink an excessive amount of water and really doesn't show the symptoms. She does still have a slight cough, but it's mild and usually happens in the morning a bit. Of course, I am keeping my eye on that. I just thought if I could help anyone who is also going through this with their pet it is so worth me sharing.

In the morning I feed her a little dry (I am using Blue right now) that is mixed with Transfer Factor, I put a dollop of cooked sweet potatoes, ground up spinach and kale (about 1/4 cup) then I add 1 tsp. flaxseeds, 1 Tbsp of tumeric, 2 Tbsp either raw chicken, salmon, tuna, 1x a day- andrographis complex, antronex, milk thistle, pituitrophin PMG, 1/2 of the pill fren-gre, melatonin at night 1mg, parotid PMG and sprinkle on her food 1 tsp.. of immunity for pets. 2x a day, congaplex and xue fu zhu wan and 8 drops of Supraglan. In addition, to mix things up I may add a T. coconut oil to her food, or use goat yogurt......I have also read where ginko biloba is recommended but I have not used it yet. I would love any feedback or advise. Thanks for letting me share my story. I will keep you updated on our progress. Peace........

Replied by Art
(Salinas, Ca)

Hi, I just took my Rocky in for rehydration for three days. If we can get his kidneys back then we have to deal with the cushings. I took him off the raw diet about one month ago. He had a seizure where his head was leaned over to one side and had lost his balance, it lasted for about 45 minutes. He then started getting very skinny. Do you have any suggestions?

Replied by Theresa
(Mpls., Mn)

Hey Art!

A 45 minute seizure is scary! If you can get the kidneys back, you might want to check for diabetes.

Replied by Cecelia
(Fredericksburg, Va)

My dog, now age 12. 5 was diagnosed with cushings disease over 2 years ago. We put him on 10 mg Vetoryl capsule, 250 mg Milk Thistle, Krill Oil, Omega treats, supplement for joints, and 225 mg Denosyl. He show no signs of the disease. We feed him high quality dog food, treats and human grade meat and veggies. His belly looks little bit pooched, but that could be due to his inactivity because of my busy schedule. I am also going to try Dynovite. My dog looks amazing. He is healthy, happy, and strong. If your dog has this disease do not be afraid to use these products. Every dollar will be well spent. I hope my input helps.

Replied by Gina Jacobsen
(Olympia, Wa)

Hello, my 12 yr old Boston terrier was just diagnosed with Cushings. I really liked your post and how descriptive you were on the things the holistic vet prescribed to you. I went and looked every item up and what they were for and thought you were on a really good regimen and wish I could go to your holistic vet! Anyhow I want to treat my beloved holistically too. I am not really interested in giving her medications like trilostane or vectoryl as some of the doctors would like, that is a last ditch effort for me. I went to a holistic vet to which he told me to go to the website lignans for life and research there for something, I'm not sure what I'm looking for. I'm very interested in knowing the doses of the supplements that you listed? I don't know how this blog stuff works as this is the first time I have done it and am curious if you'll even get this post. If you do, please respond and help, I don't know what else to do without finding another holistic vet and paying a lot of money just to start all over again. Thanks- Gina

Replied by Kathleen

My dog has had ultra sound and blood tests and has a mass on an adrenal gland which proves to be cushing disease. The only conventional cure is surgery which I don't want to put her through. She is a Dachshund about 15 lbs. I'm having difficulty finding a holistic vet in NYC. Does anyone have a suggestion for vet?

Replied by Theresa
(Mpls., Mn)

Hello Kathleen,

Try searching for a holistic vet here:

Multiple Remedies
Posted by Kally Goschke (Captain Cook, Hawaii) on 12/23/2012

My incredible vet has treated my 14 year old dog for Cushings with Rhemannia and Liver Happy chinese herbs. She has lived for 2 years with cushings and a large liver and is still going strong with ZERO side effects. I am so happy with these herbs and my dog has a very good quality of life. She can still jump in and out of car, go on hikes where it is cool, amazing. I am so glad I didn't have to give her toxic meds I want to spread the word they are not needed in the least!!

Replied by Bert

Just started my dog on Rehmannia 11, Livaplex and Cardioease as prescribed by our Vet. How long did it take before you saw improvement? She is really out of it. Dog dementia and frequent thirst and urination. She also is always hungry. She is 13 lbs and 14 1/2 years old.

Replied by Dee

Where do you buy your Rehamnnia 11? What is the dosage you give your dog?

Replied by Bert

It took two months to see any improvement with Chloe. The herbs are working and her kidneys are functioning in the normal range. Liver enzymes still high but improved. New problem is Congestive Heart Failure. We are trying to get that under control now.

Replied by Bert

I get the Rehmannia from Coastal Animal Hospital in Rockledge Fl. Your Vet can order them for you.

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