Niacinamide Treatment for Alzheimer's

Niacinamide for Alzheimer's and Dementia:

If you want just niacinamide with no additives at all and you are going to open capsules to divide your doses, you can just order pure niacinamide bulk powder such as this which should be better and cheaper:

https://www.amazon.com/BulkSupplements-Vitamin-Niacinamide-Powder-grams/dp/B00GW2LXWO/ref=sr_1_fkmr0_1_a_it?ie=UTF8&qid=1494483459&sr=8-1-fkmr0&keywords=pure+bulk+niacinamide&th=1

For people who are planning to take multiple doses per day, as some people have reported doing for Alzheimer's Disease, here is a method that might make it easier to take.

Niacinamide is water soluble, so if you are willing to do the math, you could potentially figure the total dose you want to take per week and dissolve it into water, juice, a sports drink etc.. As a basic example, let's say you want to take a total of 1,000mg of niacinamide per day in 10 divided doses or 100 mg per dose.

You would multiply the 1,000 mg daily dose times 7 to get the weekly dose of 7,000mg. Take those 7,000 mg as weighed on a cheap digital scale and dissolve it into a liter of water, juice, gatorade etc. The liter needs to be divided into 70 equal doses of 14.285 ml or just under a half ounce and each dose should deliver approximately 100 mg of niacinamide. Measure out one dose and pour it into something like a shot glass.

Make a mark on the shot glass that is equal to 14.285 ml and this is where you will fill the shot glass to for each dose. You would take ten of these partial shots each day.

By the end of 7 days the bottle should be empty. There are a couple of variations on this, but it will be easier to drink this mix than take capsules all day long and you won't be getting all of the fillers and gelatin capsules.......just the niacinamide.

Art

Hi KH. I was wondering if you could give us an update on your Mother's condition? Thanks.

I was concerned when I read that removing amyloid plaque might make matters worse, so I looked up ultrasound for dementia which has been used successfully to improve the memories of mice in experiments conducted in Australia. I was relieved to read that the ultrasound removed plaque from the mice's brains, and instead of getting worse they improved. If nattokinase can cross the blood/brain barrier, seems it would be a much simpler way to improve an Alzheimer patient's memory.

http://stm.sciencemag.org/content/7/278/278ra33

Thank you Zark;

Zark cites an article; actually an abstract from the Journal of Neuroscience. For the ones who, like me, had to wade through the technicals, essentially it said that the non-flushing form of niacin/B-3, is really helpful in reducing the amount of "forgetfulness" associated with Alzheimer's. And interestingly the very next post discussed the same benefit in psychological issues referring the reader to a Doctor Mercola interview. From my perspective, I take the flushing form almost daily to ward off migraine attacks.

Here is a relevant abstract on this matter:

Nicotinamide Restores Cognition in Alzheimer's Disease Transgenic Mice via a Mechanism Involving Sirtuin Inhibition and Selective Reduction of Thr231-Phosphotau

http://www.jneurosci.org/content/28/45/11500.abstract

Memory loss is the signature feature of Alzheimer's disease, and therapies that prevent or delay its onset are urgently needed. Effective preventive strategies likely offer the greatest and most widespread benefits. Histone deacetylase (HDAC) inhibitors increase histone acetylation and enhance memory and synaptic plasticity. We evaluated the efficacy of nicotinamide, a competitive inhibitor of the sirtuins or class III NAD+-dependent HDACs in 3xTg-AD mice, and found that it restored cognitive deficits associated with pathology. Nicotinamide selectively reduces a specific phospho-species of tau (Thr231) that is associated with microtubule depolymerization, in a manner similar to inhibition of SirT1. Nicotinamide also dramatically increased acetylated a-tubulin, a primary substrate of SirT2, and MAP2c, both of which are linked to increased microtubule stability. Reduced phosphoThr231-tau was related to a reduction of monoubiquitin-conjugated tau, suggesting that this posttranslationally modified form of tau may be rapidly degraded. Overexpression of a Thr231-phospho-mimic tau in vitro increased clearance and decreased accumulation of tau compared with wild-type tau. These preclinical findings suggest that oral nicotinamide may represent a safe treatment for AD and other tauopathies, and that phosphorylation of tau at Thr231 may regulate tau stability.

My father has dementia and is on Namenda XR and Donetezil HCL currently, but it is no longer working. I wanted to know if your mother was taking any medication when she started taking the niacinamide and if there is any danger in mixing his current meds and niaminacide?

Hi, I have read Joyce, and Kh testimony in curing their parents Alzheimer , and it gave me hope. I would like to ask them today , after one year or so how are their parents? are they still well? are their conditions , stable?

If you could answer my question or anyone who has tried the niacinamide, vitamin A , coconut oil and turmeric to share their experience please.

Thank you,

Lynda

Hello Francoise from Quebec, Canada:

Solaray makes a niacin supplement without magnesium stearate. PureBulk makes a powder form of niacin without any type of additives whatsover. Vitaspace is another powder without any additives as well.

I think the controversy about magnesium stearate is a little exaggerated but I still try to avoid it if possible. Here is a link to compare niacin supplements and their ingredients: http://www.toxinless.com/niacinamide

God Bless and hope you can find a niacin supplement to fit your needs.

Hi KH,

I am curious about the niacinamide supplement used for your Mother in curing her Alzheimer condition. All the ones I have looked at contain magnesium stearate which I understand blocks the absorption of the vitamin. One contained hypromellose, and though I have looked at various sites regarding the safety of this ingredient, I would really appreciate Earth Clinic's take on whether it is safe or not. Can you please tell us what brand was used for your Mom? Many thanks, Francoise

It has been said that one should take B vitamins with food and other B vitamins because it is synergistic. Then you read about therapies taking it on an empty stomach especially in larger doses.

My mother started taking Niacinamide 500mg twice daily for Alzheimer's and realized immediate improvement with her memory and cognitive functioning. We could see a dramatic improvement with the first dose, and continued improvement with each successive dose. Over the course of a week or so, she is functioning at close to 100%. If you have a loved one with Alzheimer's, please try this remedy.

KH, I can't thank you enough for your post!

My mother asked me to post another message about what the past few months have been like (since she started on the niacinamide). She said that it was like having windows suddenly flung open, like she could suddenly see things again that had been hidden from her.

In yesterday's post, I had reported that she had no side effects. She asked me to tell you that she tended to feel dizzy with physical exercise - for example, at the end of a walk. This is something that she has only reported since being on the niacinamide. I am just thrilled that she can remember having felt dizzy.

KH, that is wonderful!! WOW!!! Thank you so much for sharing. I am going to share this with everyone I know, including my parents!

Takes 4 Months to See Results

I forgot to mention that it took just under four months for us to see what seemed to be a full cure, but we started to notice improvement even after a few days.

For example, my mother was able to remember that my father was in the hospital after about three days on niacinamide. She was able to remember how to shower after about a week and a half, but she still forgot where the soap was. She was able to remember where the soap was a few days later.

She was able to remember to feed the dogs (and what to feed them) after about three weeks. It took almost a month for her to remember what year it was and her age.

Niacinamide worked for my mother's dementia. The dosage was time-release 1500 mg twice a day (breakfast and bedtime).

She went from asking the same question every 60 seconds (for example, she would ask where my father was, we'd answer that he was in the hospital, then seconds later she'd ask again) and being unable to take a shower because she couldn't remember how to do it, to being 100% her old normal self pre-dementia.

She can now shower and dress herself and apply her own make-up. She is back to cooking my parents' meals. She keeps the house clean. She remembers answers to questions. She is able to participate in conversations. She remembers events of the past few years that she had completely lost. She knows what year it is. She knows her age and my father's age.

Also, she had gotten very erratic emotionally. Now she's got her old personality back.

She got it all back.

She had no trouble with side effects.

We've been tapering down her dosage to see how she handles it. Right now she's on 1000 mg time release 2x a day, and so far so good.

Of course nicotine gets converted into b3.. Nicotinic acid.. Thats why the docs suggest if you got diagnosed with Alzheimer's Disease you should start smoking.. So b3 seems to be the key with the latest resesarch. I rememberd that poor whites that smoked in the southern states didnt suffer from a certain vitamin B deficiency hence nicotinic acid gets converted into b vitamins.. (correct me if im wrong).

Supposedly, according to very recent research at UC Irvine on mice, daily high doses of plain old niacinamide form of Vitamin B3 (NOT the niacin form, which gives the "hot flush"), in amounts equivalent to 2000-3000 mg/day per adult human divided into 4 doses, totally reverses Alzheimers within about 4 months!

The B Vitamins are all water soluble, so like Vitamin C to get maximum flooding of body tissues they need to be taken in doses spread out throughout the day.

Any Search with about 4 of the keywords will return dozens of results. This one is late 2009:

http://www.articlesbase.com/alternative-medicine-articles/will-remarkably-inexpensive-nutrient-cure-alzheimers-disease-1433911.html

How does niacinamide work?

Neurons are constructed with microtubules. These are scaffolding within the cells that conduct information. When the microtubules break down, the cells can die.

The tubules are like highways inside cells. Dr. Green said that niacinamide is "making a wider more stable highway. " Alzheimer's disease breaks down the highway (tubules). But niacinamide prevents this from happening.

I've previously told you how the toxic metal mercury also destroys these microtubules, potentially causing Alzheimer's disease. So anything that can prevent the damage or reverse it is a huge discovery.

Note that the mice were bred with a genetic defect to produce the amyloid plaques, so it seems the niacinamide just completely overrides that. IOW, it did not eliminate the plaques!

The articles in the Search give slight variants of the dosage. Another article says " 500mg 4 to 6 times/day".

If you have dementia of any kind, consider niacinamide, 1,500 mg twice daily.