I am currently using HP therapy to cure the prostate cancer. Results are excellent, last month I got a psa factor down by 50 units (from 325), I am very energetic. I'd like to ask a question: Is there a NECESSITY to use probiotics to restore the bacterial flora in the stomach (I drink diluted HP) or (for women) some way to restore bacterial flora in vagina if she is using a HP douche.
I'll appreciate the answer. Thank you in advance,
I used the 35% (drops in a glass of water), drank it according to "Benefits of drinking Hydrogen Peroxide, " by Dr. Williams. It cured my Prostate cancer. Also relieved my arthritis and joint pain.
hi, has anyone experienced help with prostate cancer using 35% food grade h2o2 orally? thanks, voxpop
Rustenburgn, North West, South Africa
H2O2 for Cancer
Don't get too excited about this being a cure all. I have completed the full regimen from 3 drops 3 times a day up to 25 drops 3 times a day and then stayed at 25 times a day for an additional 4 days before reducing all the way back to 3 drops 3 times a day (which is recomended as a maintenance dose) I did this for prostate cancer as a way of "doing something" while the fight is on with the insurance co to pay for treatment. After some 47 days (and those 25 drop days were really hard to take) my latest psa test came back @ 4.2 from 4.4 Not a very good result in my view. It was an option to stay at that 25 drop level for 1-3 weeks for "serious conditions" and then back off. I just couldn't do it.
I'm interested in hearing from anyone who has had experience with h202 and a high psa or prostate cancer. Thanks, Chet
I have been inhaling 3% peroxide for over 13 years. And had a bout with Melanoma and Prostate cancer at the same time. At no time would I let anything like a salve be on my open Melanoma because that would take away the oxygen needed to heal from the outside. The peroxide I inhale would supply the oxygen on the inside. I increased the times that I inhale the peroxide into my mouth to 7 or 8 times a day. I used a nasal spray pump. With each inhale I would pump the pump about 10 times. This went on for four months. I now pump 5 times with each inhale and 7 inhales every day. My EKG says I am clean now. Go to www.landrights.com.scroll down to Hydrogen Peroxide. This is where I started out.
Bill was kind enough to let us copy the following amazing testimonial on hydrogen peroxide from his website:
"Hydrogen Peroxide is the most over looked chemical used by man. New uses of it are coming to light every day. Bad bugs be they, in your garden or your body, they cannot live in an oxygen rich environment.
At 69 years old my muscles were so tight that to get out of bed I would lay on my stomach and back out on to the floor, push down on the bed and stand up. I knew there was something to correct this bad situation. One morning while having coffee with a friend, I noticed he had brought a small stack of books with him. Being curious, I asked if I could look at the books. The one that stood out to me was "O2xygen Therapies". As I was scanning it, it became more interesting to me. I asked him if I could take it home. It was a week before returning the book. Being convinced Hydrogen Peroxide was what I was looking for, it was now going to into my system? The book gave three choices. Put 8 to 10 drops in an 8 oz cup and drink it, four times a day. Next was, put a pint of 35% in the bathtub and soak for 1 hour once a week. Or go to a doctor for intravenous infusion once a week. None of these had any appeal to me.
After a week or two I decided that the easiest, and most efficient way was to inhale the 3% peroxide into my mouth and on into my lungs. I just happened to have a "Nasal Spray Pump" (see sample picture below). I dumped the contents out, put in the 3% peroxide as it comes from the drugstore. Now, how many times do I pump? I settled for one pump per inhale, and 4 times a day. That went on for about a month. As I was laying down for a short rest, I noticed that I was breathing freely. No forced inhale or exhale. That was the first thing that I noticed while inhaling the peroxide. I then changed the time when to inhale the peroxide. Now I inhale 2 times in the morning and at night. While deep inhaling I pump the pump as many times as I can, usually 8 to 10 pumps each inhale. Another thing I noticed was, I sleep all night with my mouth closed. I used to have heart aches that were very uncomfortable, no more.
My wife and I have been inhaling peroxide for 9 years now and no colds, sore muscles, aches or pains. I take no medication or vitamins. I am less than two years to 80 years old. My lungs don't give out when I work in my garden or other things around the house. My house is 160 years old, so the work never stops. Peroxide keeps our oxygen blood count in the high 90's.
One of the first people that used the peroxide as I do was very interesting. He had a low self-esteem. I found out that he was on kidney dialysis. I discussed the peroxide several times with him. Finally one day I went to his house with a nasal spray pump. He opened it and poured out the contents and filled it back up with 3% peroxide. He sprayed it in to his mouth and into his lungs. I said you know how to do it, and I left. Three days later I called him to see if anything had happened. He said that he could breath easier. Four days later he called me, he was so excited all he could say was "It's working, It's working". I asked "What did it do?". He said he was waking up about an hour and a half before normal and that he was coughing up all the bad stuff that was in his lungs. He went back to bed and when he woke up, he said he had not felt that good in years. From that time on his spirit was always good and his voice was up beat.
A couple of people told me after four or five years of using the peroxide they stopped. I ask why and both said they did not get sick, and they don't think it was working. You can make that judgement. One friend of ours goes to the doctor for pacemaker check ups and the doctor tells him the peroxide will not help him but it will not do him any harm. He is using his second pacemaker. He has told me several times; if it were not for his inhaling the peroxide he would not be here today.
Read more Hydrogen Peroxide Cures (including detailed instructions for Bill's method).
Excerpt from The National Post for Wednesday, February 3, 1999
"CLUE TO SPREAD OF CANCER DISCOVERED"
"Critical clues explaining why cancerous cells spread, uncovered by a biologist at Queen's University, may have important implications for future treatments, according to a leading international journal. The findings of Dr. Charles Graham and a team of researchers at Queen's University in Kingston, Ontario, published in the current issue of the International Journal of cancer,suggest a link between oxygen levels in cancerous tumors and the spread of the disease to other parts of the body.
"Our research shows that the low levels of oxygen in malignant tumors enhance the ability of the tumor cells to spread," said Dr. Graham. "So by manipulating oxygen levels within the tumor, we may be able to control the spreading of cancer to different parts of the body".
"We took breast cancer cells and put them under conditions of low oxygen and we saw the cells became more aggressive and invasive..."
"To spread, tumor cells must be able to break down and invade surrounding tissue barriers. Dr. Graham's research shows that hypoxia, or low oxygen levels, in the tumor mass plays an important role in stimulating the processes required for metastasis."
- National Post reporter Tom Arnold
For a really insightful viewpoint on iodine, check out this lecture by Dr. David Brownstein (http://www.internetwks.com/clips/bsBCancer.rm) about iodine and its deficiency relationship to Breast Cancer. Note he also suspects an unproven relationship between an iodine deficiency and Prostate Cancer.
He mentions that the Japanese diet includes 14mg per day of iodine on the average (coastal Japanese ingest even more.) The US RDA is 150 ugs (micro grams) per day -- about 100 times less than the Japanese eat -- and the recommended upper level for iodine is no more than 1.1 mg/day, and they estimate the average requirement to be 95 micrograms per day or about 150 times less than the Japanese consume.
The 125mg Kelp tablets that I have from Vitamin Shoppe, have 225 ugs of iodine in them. Thus, to get to the Japanese level of Iodine (14 mg/day), I would have to take 62 of these tablets a day! Dr. Brownstein also states that iodine is stored in the thyroid which requires 6 mg/day and is also stored in a women's breasts and required for proper breast development. The breasts require 5 mg/day for a 110 lb woman.
And catch this... Breast cancer researchers have to starve test animals of iodine in order to be able to induce breast cancer in any significant number of them. Hmmm...
Another 2 mg/day of iodine is required by the adrenals, hypothalamus, pituitary, and other organs. Therefore, the total required iodine for a woman is 5 6 2 = 13 mg/day. The RDA is 150 ugs per day, so a woman would have to take 86 times as much as this to achieve the 13 mg/day needed by her body, and even more if she had a larger body or bigger breasts. A man has smaller breasts and his prostate requires somewhat less iodine than a woman's breasts. However, a man's body is generally larger than 110 lbs, so this would have to be factored into the total requirements for a man.
Dr. Brownstein states, "Over the last 30 years, iodine levels have fallen over 50% in the United States. Breast cancer rates have risen dramatically. Thyroid illness from hypothyroidism, autoimmune including Grave's and Hashimoto's, as well as thyroid cancer has risen dramatically."
Since the Japanese have so much iodine in their bodies (they're ingesting 100X our 150 ug RDA of iodine), and iodine is essential for dealing with radiation exposure, it makes me wonder what might happen happen if there were a mishap involving massive radiation exposure in a country such as ours where the iodine level is so pathetically low.
And this may well be an important consideration, as cancer rates have been shown to rise after radiation has been released into the atmosphere, which apparently happened quite a bit with the use of depleted uranium (DU) weapons in Iraq in 2003. Background radiation levels were measured at many times normal in England (click this link - http://www.llrc.org/aldermastrept.pdf - and check the graphs) just a few days after the fighting started in Iraq. Cancer rates in Iraq in 2001 were about 10X what they were before Desert Storm where much less DU was used than in 2003. The big problem is that the effects are global (see: http://www.mindfully.org/Nucs/2006/DU-Europe-Moret26feb06.htm). So, the problem for us is that the DU rounds burn up or pulverize and tend to stay in the atmosphere, allowing the "aerosol of sub micron" size to enter the slip-stream and come back to America to bite us all.
Therefore, we all need to be aware of any nutritional and purification techniques which will handle radiation.
I've just upped my iodine intake to 1.35 mg/day (6 kelp tablets of 225 ug each) and I feel warmer already (maybe this will help me burn off my excess fat even faster.)
Hello, My husband has prostrate cancer and was at a Group Meeting for cancer victims.
One man at the meeting was given only 5 months to live because his cancer had spread to all his organs. His wife went out and bought a Juicer and started making him fresh vegetable and fruit juice daily!
Five months later HE WAS STILL ALIVE! When this meeting took place it had been a year and a half since he was diagnosed with his dire condition and the doctors could not understand but HIS TUMORS HAD NEARLY ALL DISAPPEARED!
Also regarding my husband's prostrate cancer:
His prostrate tumors seems to be shrinking since he started a raw fresh cabbage diet as well as juicing.
I make fresh coleslaw daily for him. As he found a study of rats with prostate cancer whose cancer either shrunk or totally disappeared with raw cabbage in their diet!
My husbands PSA reading went from a 9 to a 6!
After about 2 to 3 weeks of eating the coleslaw everyday!
Hope this helps!
in january 2009, a friend was diagnosed with prostate cancer. psa 17.1 and gleason score 5.0. he began the lemon juice and one teaspoon of baking soda, together with 125ml magnesium chloride, all in one liter of water, twice per day.
his psa test of april 3, showed a decline from 17.1 to 15.5. he continued the formula, sometimes
raising the baking soda to two teaspoons,thereby raising the urine ph to between 8 and 9, while saliva ph is between 7 and 8. in addition, he indulged the budwig diet of flax oil, cottage cheese, ground flaxseed fortified with lecithin and a banana to enhance taste. the july 1 psa test showed an increase from 15.5 to 15.9.
clearly, something is going wrong. i await your treasured comments and/or advice
in peace profound,
EC: If this is one of Ted from Bangkok's remedies, please email him directly as we no longer forward posts to him. Thanks!
PORT-OF -SPAIN, TRINIDAD AND TOBAGO
PORT-OF-SPAIN, TRINIDAD AND TOBAGO
I had severe acid reflux and ulcers. I took mastic gum by Now co. There are other companies too. I took capsules. It WILL cure both ailments,but you must keep taking it until you get symptons vanish -of course! It has been shown to fight prostate cancer. See net for tests and research. Great substance if one stays with it. A million times better than baking soda!
Update on my husband 's prostate anyway, he completely quit taking everything for almost 1 yr, because we were out of the country for awhile , and where we lived b4 molasses was not available , so with apricot seeds and other supplements, went back to the states in march of 2012 and had his psa test, the result was up and just kept on going up, last psa test was in sept 2012 and the doctor told him that he needs to see a urologists because his psa reading is 6.79 so what I did I went to work and research, and I followed everything what other people are saying here abt cayenne pepper caps 3x a day, saw palmetto , vitamin D and he also use natural progesterone creme and lots of raw cabbage, (I made lots vegetable juice, coleslaw, ) and of course lots of prayers, and after 30 days had his psa test done and it was 5.00 , thnx again earthclinic for your amazing site and the input fr other people. God bless us all and happy new year!
I stumbled upon this, supposedly from UCLA and Univ. of Cal. Any earthclinic experiences out there?
"Pomegranate boosts sex drive and fights prostate cancer."
Luckily, I'm far from prostate cancer, but I can confirm that pomegranate juice indeed seemed to increase my sex drive.
"The new research incorporated 53 male subjects with libido problems. After a month, about 50 % of the subjects said that their sexual performances increased after consuming pomegranate juice."
"A quarter of litter of pomegranate juice daily raised the stability period of prostate cancer by 4 times, with such a significant effect... "
Prostate TUMOR SHRINKER FORMULA:
Diindoly Methane (DIM) 100 mg. * Chrysin 500 mg. Nettle Root 250 mg. Bioperine 10 mg. * Phytosterol Complex 937 mg. * (BETA-SITOSTEROL 375 MG.) Lycopene 30 mg. Ascorbic Acid (Vitamin C) 1,000 mg. Curcumin 1,500 mg. ** Selinium 200 mcg. Vitamin-D 200 IU Genistein Soy Complex 1000 mg. * Saw Palmetto 160 mg.
The above formula is taken twice daily (2 times the above total).
Items marked "*" can be purchased at www.sourcenaturalscatalog.com
Items marked "**" can be purchased at www.physicianformulas.com
Nettle Root can be purchased at www.swansonvitamins.com
A source for Chrysin can be obtained from a Google search. Lycopene, selenium, Vitamin C and E can be purchased at Wal-Mart.. .
The above should be supplemented with a good Vitamin-Mineral formula. NOTHING SHOULD BE LEFT OUT OF THIS FORMULA, except as indicated by your health care provider. The above FORMULA and statements have not been evaluated by the Food And Drug Administration. This FORMULA is not intended to diagnose, treat, cure or prevent any disease.
Chicago, Il, U.S.A.
My husband has taken prescription meds for enlarged prostate for more than a decade. We are both trying to end the Rx dependency. So, after much research, and a discussion with his dr who said herbal meds cant possibly replace Rx drugs, he has eliminated the Rx drugs using saw palmetto and stinging nettle in their place. He did a gradual shift and has found the herbs as effective without the side effects. Yeah! For that since one side effect was very bad breath that tended to distance our relationship!
For years I have tolerated growing onslaught of misinformation about Soy even though most studies relating to soy is quite positive. Today, I am angry and decided to post this myself.
If you don't believe me that soy is good for you, you don't have to! You can prove this for yourself! I will tell you how! The secret is here.
Do this: go to www.pubmed.org and do a search using the following keyword as follows:
- soy cancer
- soy dht
- soy testosterone
- soy estrogen
- soy osteoporosis
You will then learn the truth and you don't even have to believe me. I have done this for you already, and here are the summaries in case you don't have time! True information that I will post the research citations verbatim directly from research studies as follows:
1. DHT hormones (dihydrotestosterone) are the major cause of male hormone baldness. When lack of testosterone does not generate that much DHT stays on your head. The only known substance to reduce that is DHT.
2. Phytoestrogen has no effect on estrogen levels or hormone levels or even testosterone.
3. Soy helps with osteoporosis.
4. Soy reduces cancer and is used to treat cancer victims.
I will post the medical abstracts verbatim below.
Now the reason why such a relentless attack on soy is that there are ulterior motives from certain interest groups such as
1. Decreasing milk cows sales.
2. the use of genetically modified cows
3. the use of bovine growth hormones injected into cows which we drink and may cause obesity
4. The prevalence of mad cow's disease
5. The findings of a chemical toxins and toxic vaccines and might be found in cow's milk.
I am an Asian, here where I live we actually consume more soy milk then even fermented soy products. And it has kept us relatively low of osteoporosis.
Because of so much bombardment against soy, I will not put any thing here besides research abstract below. Ted"
Nope: soy does not effect testosterone:
Serum prostate-specific antigen but not testosterone levels decrease in a randomized soy intervention among men.
Maskarinec G, Morimoto Y, Hebshi S, Sharma S, Franke AA, Stanczyk FZ.
1Cancer Research Center of Hawaii, University of Hawaii, Honolulu, HI, USA.
Background: Low prostate cancer incidence and high soy intake in Asian countries suggest a possible protective effect of soy foods against prostate cancer. The goal of this pilot study was to evaluate the feasibility of a randomized, crossover soy trial among men and to investigate the effects of daily soy intake on serum prostate-specific antigen (PSA) and testosterone levels.Methods:We randomized 24 men to a high or a low soy diet for 3 months. After a 1-month washout period, the men crossed over to the other treatment. During the high soy diet, the men consumed two daily soy servings; during the low soy diet, they maintained their usual diet. During the entire study each man donated four blood samples and five overnight urine samples. Dietary compliance was assessed by soy calendars, 24-h dietary recalls, and urinary isoflavone excretion measured by high-pressure liquid chromatography with photodiode array detection. Blood samples were analyzed for serum testosterone and PSA by radioimmunoassay. When necessary, variables were log transformed. Two sample t-tests compared the two groups before each study period. Mixed models incorporating the repeated measurements were used to evaluate the effect of the soy diet on urinary isoflavone excretion and serum analytes.Results:Twenty-three men aged 58.7+/-7.2 years completed the study. The compliance with the study regimen was high according to self-reported soy food intake and urinary isoflavone excretion. No significant between-group and within-group differences were detected. During the high soy diet, dietary isoflavone intake and urinary isoflavone excretion increased significantly as compared to the low soy diet. A 14% decline in serum PSA levels (P=0.10), but no change in testosterone (P=0.70), was observed during the high soy diet in contrast to the low soy diet.Conclusion:The high adherence as shown by three measures of compliance in this pilot trial demonstrated the feasibility of an intervention based on soy foods among free-living men.European Journal of Clinical Nutrition advance online publication, 14 June 2006; doi:10.1038/sj.ejcn.1602473.
PMID: 16775579 [PubMed - as supplied by publisher]
Asians have less osteporosis because of soy milk consumption! We consume more soy milk then the so called fermented things that Dr. Mercola claims!
Osteoporosis prevention education programme for women. Chan MF, Ko CY.
School of Nursing, The Hong Kong Polytechnic University, Hung Hom, Hong Kong SAR, China. [email protected]
AIM: This paper reports an evaluation of a nurse-initiated education programme on four specific osteoporosis prevention behaviours which led to their adoption or to positive attitude changes.
BACKGROUND: In the past, osteoporosis was a serious health concern that most commonly affected women in Northern Europe and the United States of America, but was less commonly seen in Asian women. However, in Hong Kong, osteoporosis is currently among the top five conditions causing disability and prolonged hospital stay for older people. From an economic perspective, the most cost-effective approach is to focus on primary prevention via education, and nurses often have the responsibility of providing such educational programmes.
METHOD: A randomized controlled study was conducted from July 2004 to March 2005 with 76 women (38 cases and 38 controls) recruited in two private beauty clinics in Hong Kong. Pre-, post- and follow-up education data were compared regarding attitudes and adoption frequency before and after the education programme. RESULTS: The results showed statistically significant increases for each behaviour: consumption of soy foods (P < 0.001), milk (P < 0.001), more exercise (P = 0.01) and vitamin D/exposure to sunlight (P < 0.001) for the case group compared with the control group. Most participants either disagreed (n = 15, 39.0%) or strongly disagreed (n = 23, 61.0%) that there was not enough information provided in the education programme to motivate them to change. They rated the nurse's performance as either satisfactory or very satisfactory on presentation, ability to answer their questions and ability to describe each behaviour clearly.
CONCLUSION: Although positive results with a nurse-initiated education programme were demonstrated, future research examining the effects of education and occupation on these four adoption behaviours should focus on more diverse populations with respect to age, income or ethnicity. The findings suggest the value of creative approaches in future health education for the prevention of osteoporosis, and the need for a critical appraisal of current strategies and a re-evaluation of services and funding.
PMID: 16553702 [PubMed - in process]
A rat study confirms improved bone when fed with soy
Soy affects trabecular microarchitecture and favorably alters select bone-specific gene expressions in a male rat model of osteoporosis.
Soung DY, Devareddy L, Khalil DA, Hooshmand S, Patade A, Lucas EA, Arjmandi BH.
Department of Nutrition, Food & Exercise Sciences, Florida State University, 436 Sandels Bldg, Tallahassee, Florida, 32306-1493, USA, [email protected].
We have recently reported that soy isoflavones particularly when provided in the context of soy protein are capable of preventing loss of bone mineral density due to orchidectomy in F344 rats. We hypothesize, that soy isoflavones also exert beneficial effects on bone microstructural properties, in part, by enhancing bone formation. Therefore, in the present study, we examined the dose-dependent effects of soy isoflavones on femoral bone microarchitectural properties and select bone-specific gene expressions in the same rat model. Seventy-two, 13-month old rats were either orchidectomized (ORX; 5 groups) or sham-operated (Sham; 1 group) and immediately placed on dietary treatments for 180 days. Four of the ORX groups were fed either casein- or soy protein-based diets each with one of two doses of isoflavones either 600 or 1200 mg/kg diet. Rats in the remaining ORX control and Sham groups were fed a control casein-based diet. Soy protein at the high isoflavone dose, and to a lesser extent with the lower dose, reduced the magnitude of the ORX-induced decreases in trabecular bone volume (BV/TV) and trabecular number (Th.N) and increase in trabecular separation (Tb.Sp) at the femoral neck site. These modulations of trabecular microstructural properties by isoflavones may be due to increased mRNA levels of alkaline phosphatase (ALP), collagen type I (COL), and osteocalcin (OC), which are associated with enhanced bone formation. These findings confirm our earlier observations that the modest bone protective effects of soy isoflavones are due to increased rate of bone formation.
PMID: 16830200 [PubMed - in process
Soy reduces dangerous DHT that causes you to go bald But yet had no effect on good hormones!
1: J Nutr. 2005 Mar;135(3):584-91.
Soy protein isolates of varying isoflavone content exert minor effects on serum reproductive hormones in healthy young men.
Dillingham BL, McVeigh BL, Lampe JW, Duncan AM.
Department of Human Biology and Nutritional Sciences, University of Guelph, Guelph, Ontario N1G 2W1, Canada.
Inverse associations between soy and prostate cancer and the contribution of hormones to prostate cancer prompted the current study to determine whether soy protein could alter serum hormones in men. Thirty-five men consumed milk protein isolate (MPI), low-isoflavone soy protein isolate (SPI) (low-iso SPI; 1.64 +/- 0.19 mg isoflavones/d), and high-iso SPI (61.7 +/- 7.35 mg isoflavones/d) for 57 d each in a randomized crossover design. Twenty-four-hour urine samples indicated that urinary isoflavones were significantly increased by the high-iso SPI relative to the low-iso SPI and MPI. Serum collected on d 1, 29, and 57 of each treatment revealed that dihydrotestosterone (DHT) and DHT/testosterone were significantly decreased by the low-iso SPI [9.4% (P = 0.036) and 9.0% (P = 0.004), respectively] and the high-iso SPI [15% (P = 0.047) and 14% (P = 0.013), respectively], compared with the MPI at d 57. Other significant effects included a decrease in testosterone by the low-iso SPI relative to the MPI (P = 0.023) and high-iso SPI (P = 0.020) at d 29; an increase in dehydroepiandrosterone sulfate by the low-iso SPI relative to the MPI at d 29 (P = 0.001) and relative to the MPI (P = 0.0003) and high-iso SPI (P = 0.005) at d 57; and increases in estradiol and estrone by the low-iso SPI relative to the MPI at d 57 (P = 0.010 and P = 0.005, respectively). In conclusion, soy protein, regardless of isoflavone content, decreased DHT and DHT/testosterone with minor effects on other hormones, providing evidence for some effects of soy protein on hormones. The relevance of the magnitude of these effects to future prostate cancer risk requires further investigation.
PMID: 15735098 [PubMed - indexed for MEDLINE]
Soy is used in cancer treatment!! Cancer causing? You have been lied to by the Cow's milk consortium! Yes it protects against Prostate Cancer!
Effects of a diet rich in phytoestrogens on prostate-specific antigen and sex hormones in men diagnosed with prostate cancer.
Dalais FS, Meliala A, Wattanapenpaiboon N, Frydenberg M, Suter DA, Thomson WK, Wahlqvist ML.
International Health and Development Unit, Monash University, Clayton, VIC, Australia.
OBJECTIVES: To determine the effects of diets rich in soy and linseed compared with a control diet on biochemical markers of prostate cancer in men diagnosed with prostate cancer. METHODS: Twenty-nine men diagnosed with prostate cancer and scheduled to undergo a radical prostatectomy were randomized to one of three groups: soy (high phytoestrogen), soy and linseed (high phytoestrogen), or wheat (low phytoestrogen). A bread was specially manufactured to incorporate 50 g of heat-treated (HT) soy grits or 50 g of HT soy grits and 20 g of linseed as part of the study participant's daily diet. Baseline and preoperative levels of prostate-specific antigen (PSA), free PSA, testosterone, sex hormone-binding globulin, free androgen index, and dihydrotestosterone were measured. RESULTS: Statistically significant differences were detected between the HT soy grits group and the control wheat group for the percentage of change in total PSA (-12.7% versus 40%, P = 0.02) and the percentage of change in free/total PSA ratio (27.4% versus -15.6%, P = 0.01); and between the HT soy grits group and the HT soy grits and linseed group for the percentage of change in free androgen index (16.4% versus -15.5%, P = 0.04) and the percentage of change in free/total PSA ratio (27.4% versus -10%, P = 0.007). CONCLUSIONS: The data from this study indicate that a daily diet containing four slices of a bread rich in HT soy grits favorably influences the PSA level and the free/total PSA ratio in patients with prostate cancer. This work provides some evidence to support epidemiologic studies claiming that male populations who consume high phytoestrogen diets have a reduced risk of prostate cancer development and progression.
PMID: 15351581 [PubMed - indexed for MEDLINE]
Genistein and daizein is o.k.
Genistein and daidzein downregulate prostate androgen-regulated transcript-1 (PART-1) gene expression induced by dihydrotestosterone in human prostate LNCaP cancer cells. Yu L, Blackburn GL, Zhou JR.
Nutrition/Metabolism Laboratory, Department of Surgery, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Epidemiologic investigations and laboratory studies suggest that bioactive soy phytochemical components may be used as an effective dietary regimen for prevention of prostate cancer. Studies designed to identify new genes that are responsive to androgens and are sensitive to the prevention of prostate cancer using soy bioactive components have become a research priority. In this study, we determined the effect of soy isoflavones on the expression of prostate androgen-regulated transcript 1 (PART-1), a newly discovered androgen-induced gene that may represent a novel androgen-dependent prostate cancer tumor marker. In an androgen-depleted cell culture system, 5alpha-dihydrotestosterone (DHT) induced expression of PART-1 transcript in androgen-sensitive LNCaP, but not in androgen-independent DU 145 or PC-3 human prostate cancer cells. The soy isoflavones genistein and daidzein dose-dependently inhibited DHT-induced expression of the PART-1 transcript. Genistein at 50 micro mol/L completely inhibited expression of the PART-1 transcript in LNCaP cells induced by DHT at 0.1 and 1.0 nmol/L. Daidzein was less potent than genistein, whereas glycitein at the same levels as genistein or daidzein did not inhibit DHT-induced PART-1 transcript expression. Our studies suggest that use of the PART-1 gene as a biomarker for evaluating the efficacy of soy isoflavones on androgen-dependent prostate cancer warrants further investigation.
PMID: 12566472 [PubMed - indexed for MEDLINE]