★★★★★
B1 (thiamine) deficiency is a common cause of dysautonomia. Unfortunately, for some people injections or cream will be needed as their genetic makeup doesn't allow them to assimilate it. Putting some powder under the tongue and allowing it to melt bypasses digestion as well.
I had bad heartbeats after getting up and some shakiness, especially bad at night, if I had to go to the bathroom. It took a week or so to become better when putting some B1 powder under the tongue 3-4 times a day. But I also took cayenne 2 capsules 2-3 times daily, which I felt helped a lot too.
I also take B complex, B2 (for migraines) and B12.
Mine was triggered by 18 day juice fast, and severe stress.I think that made bad B1 status even worse. I haven't tried Butcher's broom herb, but that is supposed to be good as well.
★★★★★
Atenolol
Butcher's Broom +
★★★★☆
My teenage son was recently diagnosed with dysautonomia. We are at a functional neurology center that, despite my skepticism, is helping. I don't have enough mileage to call any of these a 'cure' but we are experimenting with - butcher's broom (herb) 2x per day, building up calf muscles to better move blood, hydration drinks, and red light therapy behind the knee.
★★★★☆
If blood pressure drops, it is not POTS. POTS comes with many other debilitating symptoms. Not only teenagers get it. Cervical cancer vaccine causes POTS. Managing pots is very difficult. There is no one size fits all.
I have tried everything there's to try in alternative medicine field, from supplements to modalities, nothing worked for me. I have it for 10 years. Only atenolol allows me to semi function, but it only addresses heart rate elevation, not the other 50 symptoms that come with POTS.
Atenolol
I developed POTS at age 44, I am now 47 and still have it. I also did a pole in a large pots group and was surprised to see a surprising amount of potsies 40-60. It's important that people are aware because I went 2 years not knowing what was wrong with me.
Atenolol
Multiple Remedies
God blessings.
Multiple Remedies
The best doctor we have found is at Vanderbilt University during a drug trial. My wife was a non-responder to new drug, but Vanderbilt drug trial director and doctor would not let leave until they found a medication she could use. It was great. We continue to see this doctor (Cyndy Chibao) twice a year. My wife is mostly functional with medication. She takes FlorineF and Octreotide in day time to raise her blood pressure and sildenafil at night to lower her blood pressure. We also found out that after meals her blood pressure would drop so Acarbose was added for that and it has helped. We monitor her blood pressure 4 times a day 2 readings at night and 2 a day. Her high nighttime blood pressure has damaged her one eye and her last blood test indicated poor kidney function.
So, it is a balancing act getting enough medication to raise her Blood pressure in daytime and enough at night to ensure safe sleeping blood pressure. Hope this helps.
Butcher's Broom +
Must be super hard as a mom to see your kid suffering. Sending hugs to both of you.
(I used to use Butcher's Broom and it noticeably helped. For some reason, I can't tolerate it now, but it's really worth trying out, imo.)
Atenolol
Here is how your location and genetics could be interacting to cause health issues:
1. The HLA Haplotype and Immune Response
Specific HLA (Human Leukocyte Antigen) haplotypes, which determine how your immune system recognizes threats, can make you more susceptible to specific environmental triggers.
Environmental Sensitivity: Certain haplotypes may predispose you to severe immune reactions to mold, toxins, or Lyme disease, causing chronic fatigue, inflammation, and cognitive issues (brain fog).
Immune Misregulation: If you are in a location with specific infections or stressors that your particular haplotype cannot handle well, it can lead to chronic, low-grade inflammation.
2. Environmental Mismatch and Metabolic Issues
Your DNA may be "programmed" for a different environment. When that environment changes rapidly, it can lead to chronic disease.
Inuit Studies: Studies show that genetic variants (like in the ORMDL3 gene) can increase the risk of respiratory diseases like asthma and bronchitis, but this risk is significantly higher when moving from a traditional environment to a Westernized environment.
Metabolic and Digestive Disorders: Specific haplotypes, particularly in mitochondrial DNA or genes related to diet (like lactase persistence), are matched to specific geographical locations. Living in a location that does not match your ancestral diet or climate can lead to metabolic issues.
3. Location-Specific Triggers
Where you live can impact gene expression via environmental epigenetics, where external factors turn certain genes on or off.
Toxic Exposures: Genetic variants in detoxification genes (e.g., GSTM1) can mean your body struggles to break down environmental pollutants in specific areas.
Climate Factors: Differences in air quality, temperature, and sun exposure can activate different genetic pathways, leading to illnesses that vary by region.
Summary of How to Investigate
HLA Typing: Some practitioners use HLA typing to help identify why a patient might be highly sensitive to their specific environment.
Identify Triggers: Consider if your symptoms change when you travel or if they align with local environmental factors (humidity/mold, high pollution, specific toxins)
While your genes are not a "life sentence, " they can mean that certain environments are less optimal for you, triggering symptoms that wouldn't exist in a different setting.
While your genes are not a "life sentence, " they can mean that certain environments are less optimal for you, triggering symptoms that wouldn't exist in a different setting.
Could a different location help?
If your chronic issues are driven by specific environmental triggers (like humidity, high altitude, or specific allergens), relocating might reduce your "toxic load" or immune activation.
If your chronic condition doesn't respond to treatments, you could be living in a wrong place
Multiple Remedies
★★★☆☆
- feet are numb tingle
- neck and head pain
- mornings are hell with palpitations shortness of breath body ache.
- Excessive urination at night, 1.5 liter or more
- - exercise intolerance
- colld and heat Intolerance
- disturbed sleep
- brutal pain. after sittting more than an hour
taking many supplements, eating clean
b vitamins nerve support
After leaky gut from Lyme
Loooking into plasma exchange and hyperbaric oxygen treatments
Desperate for help and feedback and support and ideas on anything
Multiple Remedies
Butcher's Broom +
I'm really exploring thiamine, though I can barely tolerate it right now. (That doesn't mean I don't need it! ) There's a great (large and expensive) book on dysautonomia (an umbrella term, of course) and thiamine. I'm also exploring riboflavin. I know several folks who no longer have OH after using riboflavin. I have these in tinctures and am literally starting out at a drop and working my way up.
My OH is greatly impacting my life. My cognitive functioning, mostly.
Atenolol
My maternal haplotype is J1c5 (from 23andme) and I live in Florida.
Origins: The J1c5 lineage emerged approximately 7,450 years ago (around 5450 BCE), likely in the Near East or the Caucasus region.
Historical Spread: It spread into Europe and the Mediterranean during the Neolithic expansion of farming. Today, it is found across Europe, the Near East, North Africa, and among Jewish communities.
Common Locations: Besides Europe and the Middle East, it has also been observed in populations as far as Siberia and India.
The Theory of Environmental Mismatch
The idea of "mismatch" typically focuses on how mitochondrial DNA (mtDNA) handles energy and heat production:
Heat Production: Some researchers theorize that haplogroup J (including subclades like J1c) may produce more body heat as a byproduct of metabolism. This is thought to have been an evolutionary advantage for surviving cold northern winters, such as those in Northern Europe.
Metabolic Efficiency: Mitochondria in the J group are sometimes found to be less efficient at producing ATP (energy) but generate more heat.
In warm climates (like Florida): Under this theory, a body naturally "tuned" to generate extra heat might find hot, humid environments more stressful.
So it is possible for my J1c5 maternal haplogroup to experience an environmental mismatch in Florida.
2. The Potential Mismatch (Florida Environment)
Climate Change: Moving from temperate areas to the hot, humid, subtropical climate of Florida is a dramatic environmental shift.
Oxidative Stress: Because J1c5 mitochondria are adapted to generate higher heat, they may be less efficient in a permanently hot environment, potentially leading to higher oxidative stress, which is a key factor in metabolic and degenerative diseases.
3. Does this cause health issues?
Susceptibility: Studies have found that mitochondrial haplogroups within the J lineage, due to their specific energy-producing adaptations, may have different susceptibilities to diseases (such as those involving vision or metabolism) depending on their environment.
Summary: My J1c5 ancestry likely developed to thrive in temperate, slightly cooler conditions. While not a direct disease, living in Florida—a very different, warmer, and more humid environment—represents a "novel" environment compared to my"ancestral" environment, creating a potential environmental mismatch in terms of metabolic efficiency.
IMPORTANT:
Our nuclear DNA is inherited from both parents. Paternal haplogroups are defined by sets of genetic variants on the Y chromosome.
Females do not inherit Y chromosomes and as a result, do not have paternal haplogroups. People with no Y chromosome may connect with a male parent or siblings, or other close male paternal relatives, to trace their ancient paternal line. Unfortunately I have no paternal male relatives or siblings.
I hope this information helps you to realize that sometime your chronic degenerative health issues could be caused by environmental mismatch
Atenolol
Enzymes in DNA Repair dysautonomia
Enzymes in DNA Repair, then nutrients, then herbs...
Enzymes involved in DNA repair, such as OGG1 and polymerase beta
nutrients needed for OGG1
Example: what nutrients support TH10785, then what medicinal herbs. Do this for every little odd connection, pathway etc.
TH10785, general nutrients that support DNA repair and cellular health include antioxidants like vitamins C and E, zinc, and selenium.
nutrients that support Deoxyribonucleotide Triphosphates (dNTPs) and then medicinal herbs….
histamine and Dysautonomia
Just a thought, your right not a lot of research on this disorder, but DNA repair and histone deacetylase inhibitors. Think around the disorder.
Hope this helps:)
Multiple Remedies
Multiple Remedies
POTS
Janet
Butcher's Broom +
In my previous reply, I meant to say orthostatic hypotension.
Art
Atenolol
Atenolol
Hope this can help! Herbal medicine and Acupuncture.
https://thebuffaloherbalist.substack.com/p/nervous-system-dysregulation-cortisol
difference between dysautonomia and dysregulation, and how herbs help restore your natural rhythm.
https://myartofwellness.com/how-to-treat-dysautonomia-with-acupuncture-and-tcm/
Atenolol
Understanding the stress response, the difference between dysautonomia and dysregulation, and how herbs help restore your natural rhythm
https://myartofwellness.com/how-to-treat-dysautonomia-with-acupuncture-and-tcm/
Atenolol
Multiple Remedies
Multiple Remedies
The ANSD means sometimes I can't move, I can't get out of bed because my body can't respond to brain commands, it takes me a long while to be able to move. (This is an extreme symptom that occurs about once a month) Last summer, the cops were sent to my door cos the manager refused the rent the night before, without notice told me I had to move and the worst struck during the night, and I couldn't move.
This time, I had intense coccyx pain, extremely painful in bed when coughing and I was forced to move. I need a home but due to no credit score, I can't rent anywhere and I am autistic, so I can't live with others: I seem to attract nothing but abusive people and I can't cope with that. It destroys my health further, adrenals are shot. And that's not counting with all the mental damages. Count your blessings if you're not homeless or have family. You could be so much worse!
I am heat intolerant and live in So Cal. I have wanted to move to cooler climate for the past 20 years but I can't: I don't know anyone and I can't do much for myself. If anyone can help, with a permanent solution to any of these illnesses please post. Particularly how to detox the metals. I was supposed to get IVs 15 years ago, but I couldn't manage due moving constantly and I am old now, can't cope with living like this much longer. Thanks for reading.
Thiamine, B Complex, Cayenne
Atenolol
Atenolol
Also, have you had a hair analysis of your heavy metals and essential minerals?
Atenolol
Atenolol
Which is more efficient: moving when there is an environmental mismatch, or using genes manipulation with medicinal herbs and supplements?
Here is the answer:
Moving (changing your environment to match your biology) is generally considered more efficient for addressing the root cause of an evolutionary mismatch than trying to fix the mismatch with medicinal herbs and supplements. While supplements can help manage symptoms of a mismatch, they do not resolve the underlying disparity between ancient human biology and modern environments.
Moving to align with ancestral biology is a long-term, structural solution to environmental mismatch.
Environmental factors like pollution and lifestyle significantly impact health more than supplements can counter alone. An "evolutionary mismatch" means our traits are ill-suited for modern settings. While medicinal plants are valuable, they are often used to address the immediate damage caused by this gap rather than eliminating the gap itself.
Multiple Remedies
Thank you.
POTS
