I just turned 44 and I have had Melasma since I was 30. It started on my upper lip and progressed to my cheeks, nose and chin. It has been pretty severe over the years. I have tried everything from hydroquinone (which made it darker) to lasers (which made it go nearly black and it took forever to lighten to the original shade of brown) and everything in between. Cosmelan had given me the best results, but it does adversely affect my skin texture and it eventually darkens again anyway.
I have been taking MSM, Glutathione, Vitamin C and GSE [grapefruit seed extract] for about two months now. I went through a detox period which included headaches, fatigue and a little bit of breakout. This was pretty bad for about the first month, but because my skin was lightening so much I kept on. I have been able to gradually increase my dose of MSM to 12,000 mg a day, 6,000 in the A.M. and 6,000 at night. I take 10,000 mg of vitamin c spread out in three doses, 2,000 mg of Glutathione mid-day and 15-20 drops of GSE (in a little bit of grapefruit juice to hide the taste) two to three times a day. My spots faded pretty rapidly at first and I have to say, I am thrilled! They are about 70% gone now. I seem to have hit a plateau but I am reticent to increase my doses as I already feel that they are quite high. I just started using MSM topically to see if that will help. I put 1 teaspoon of the powder into my face cream and my skin is peeling but not at all sore or red. Does anyone know if this is a normal reaction? I'm going to keep trying this and I will keep you posted on my progress.