Do biofilms evolve in the pancreas? I am trying to understand biofilms and how they are produced/where they begin?
I had not heard of them before EC.
You know, this brings up something I have missed, the cancer cell line. I have no idea the HCT-. My cancer is really considered rectal due to location.
I found this quote that I thought you might find of interest,
>>> ' Except for AgNP1, the growth inhibition potency of AgNP formulations of human colon tumor cancer cells (HCT-15) is 34.5 times higher than carboplatin, one of the first-line chemotherapy agents. Nevertheless, 5-10% of necrotic events, even at the lower concentration evaluated, were observed. The cytotoxic selectivity was confirmed by evaluating the cytotoxic effect on aorta, spleen, heart, liver, and kidney primary cultures from BALB/c mice. Despite the cytotoxic effects observed in vitro, the lethal dose and histopathological analysis showed the low toxicity of these formulations (all of them on Category 4 of the Globally Harmonized System of Classification and Labelling of Chemicals) and minor damage observed on analyzed organs. ' <<<
Here is where that quote came from :
Considering that AgNPs (Colloidal Silver Nanoparticles) have also been shown to destroy some biofilms of certain bacteria that are noted for contributing to the formation of colon cancer, AgNPs seem to be worth reading about. If I'm not mistaken, I believe Earth Clinic has just started selling colloidal silver or will be soon.
Hi Art, yes CRC. Had to work up NAC to 2400mg per day. Started at 1200mg per day. IP6 is one that gets my gut still to this day. Thank you for explaining bacteria and biofilms. The body is an amazing machine but needs help sometimes for sure. EC is great and so are you.
I think I forgot to include that study link showing how silver can have a negative impact on the gut microbiome, so here is the link I was referring to :
Notice that even after 8 weeks post AgNPs, the gut biome was not fully restored in some cases. Their max dose of silver nanoparticles used in this study for the mice was 2.5 mg/kg. When compared to a human equivalence for somebody around my size this would be approximately 16.5 mg/AgNPs/day or roughly about 3/4ths of one quart of 20 ppm colloidal silver per day. This is a lower dose than my standard loading dose, but higher than my standard maintenance dose of AgNPs to fight a pathogen in my body. The lowest dose used in this study, in my opinion, is too low to be useful against pathogens, but even that dose had a negative effect on the gut microbiome. The decrease in short chain fatty acids or SCFAs is very bad for us on a longer term basis as these help in multiple ways to maintain gut homeostasis and are often depleted in multiple disease states.
You must have a tough stomach! I wasn't able to handle 2400 mg of NAC for long. You didn't say what type of cancer, but if it is colon cancer (CC), taking a biofilm buster like NAC can be useful in breaking down biofilms which protect bacteria that are noted for protecting certain bacteria that contribute to CC. It is important to remember that CA is not the only pathogen that uses biofilms to protect itself and utilizing these biofilm busters can be useful against many other biofilm forming pathogens!
Thank you for sharing this important piece of information about colloidal silver. I had not heard of the study on animals showing its impact on gut microbiome and time needed to rebalance the gut. Thank you for all your contributions to our EC community :)
Thank you, Art! I have been on NAC (2400mg) for a while as part of my anti-cancer protocol.
A dosage of less than 600 mg/day would be a low dose. In the case of CA, 1200 seems like it may be more useful based on what that study showed and most people should be able to tolerate that dose. I ran into problems when I got to 2400 mg/day in divided doses. My stomach couldn't handle 2400 mg of NAC after just a very short test at that dose.
I believe that there are definite benefits to taking the potent antioxidant and antiinflammatory NAC on the regular, but my view of Colloidal Silver(CS) is not the same and I will explain why.
I look at CS as a potent antibacterial with some similarities to antibiotics. I also see it as a potent antiviral with some similarities to prescription antivirals. It also has antifungal effects that can rival some antifungal prescription medications as well as modest anti parasitic effects.
Would you take an antibiotic, antiviral, antifungal or anti parasitic for the rest of your life whether you needed it or not? Probably not. Since CS has these very specific activities, my opinion is that I should reserve it for when I really need it and the reason for this is simple. There are already bacterial strains that are resistant to CS and taking low to moderate doses of CS everyday is likely to create more bacteria that are resistant to CS and this is something that we absolutely don't need!
I know a lot of people will not like the above statement because they take lower doses of CS daily and feel that it keeps them healthy and I don't doubt it, but this is one way that bacteria can become resistant to CS after long exposure at sub-toxic dosing levels. This is already more than evident with prescription antibiotics where there are now many bacteria that are becoming extremely resistant to these antibiotics that used to be highly effective not long ago. A good example of this is Methicillin Resistant Staphylococcus Aureus or MRSA which is becoming more and more common everyday.
The other thing to consider is that CS is a broad spectrum antimicrobial and as such will kill some good bacteria along with the bad. It may kill more pathogenic bacteria than healthful bacteria, but the fact remains that it does kill good bacteria also and this ultimately has the potential to have a negative impact on the gut microbiome and a perturbed gut microbiome is absolutely not good for our long term health! This recent study, although only an animal study, shows the negative impact that CS can have in terms of reduced gut microbiome diversity and reduced short chain fatty acids which are both bad for our longer term health outlook. It also showed that it can take 8 weeks to recover most of the deficits created by CS. If you use it everyday, it may be impossible for the gut microbiome to ever recover resulting in gut dysbiosis which is not a good thing by any stretch of the imagination.
My preference is to conserve CS for times when I absolutely need it and use it no longer than is needed to achieve the desired effects, such as destruction of a toxic bacterial overgrowth.
What is considered a low dose of N.A.C and what is a high dose?
Coco - Oklahoma
Hello Ed. F.,
Although there is significant anecdotal evidence for using serrapeptase for CA, there are no studies currently available that confirm that action. Given the known activity of serrapeptase, it seems likely that it should be active against CA, so it definitely seems worth a try and if it turns out be not effective enough, you can always try the ones I mentioned.
Yes, Stevia has anti Candida a. qualities also.
Terrific article, thank you.
Would taking the Colloidal Silver and NAC alone be beneficial to one's health?Thank you,
What about serrapeptase opening biofilm and black seed oil to kill the toxins, then binder to flush out? Will this work also?
What about Stevia for CA? Stevia combats Lyme...