Berberine works well by itself at lowering blood sugar.
My wife has DM2 and along with it, all the other problems. The doctors had her taking several hypertension meds, as well as Metformin and a water pill. I had heard of Berberine in the past, and really wanted to try it with her, but was a little hesitant. On a recent trip to the doctor's office, her bloodwork showed that her kidney function was dropping and the doctor told us to drop the Metformin and water pill because they were too hard on her kidneys. I had tried a combination of Metformin and Berberine before, without good results, so I still had the Berberine on the shelf and ready for action.
I started giving her Berberine twice a day with breakfast and dinner, and also added 300 mg of alpha-lipoic acid at breakfast and bedtime for water retention. Within a very short period of time, we saw such a difference.
Her fasting sugar dropped to 100 + or - 10 and we had to reduce her nightly insulin injection by 10 units to keep it from going too low. (One morning her sugar was down to 60 and very scary.) The ALA also reduced the swelling in her legs and feet. Now her shoes don't look like they are two sizes too small and her ankles no longer have marks from the elastic in her socks.
The combination of the two ( both available on Amazon) has made a real difference in her blood sugar as well as the edema that goes along with hypertension.