Asthma and Grape Seed Extract

on Jun 30, 2022
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Grape Seed Extract and Asthma.

To be clear, I will be discussing Grape Seed Proanthocyanidin Extract which is typically referred to as GSPE or more commonly as GSE, but this is not to be confused with Grapefruit Seed Extract, which is also commonly referred to as GSE, but these are two very different supplements with different effects.

Last week I had breakfast with a group of friends and one friend told me that their doctor had just diagnosed her with adult onset Asthma. The doctor told her that this will likely be with her for the rest of her life and he prescribed her an inhaler that contains a steroid. She said she felt like the inhaler did not seem to be helping her much as she still felt tightness, congestion and discomfort. She said that she had heard that long term steroid use could cause other health issues and asked me about any alternatives that might be useful. I told her that I was aware of a few possible remedies, but suggested she only try one at a time until she found one that would be effective for her.

I suggested Grape Seed Extract (GSE) at high dose because I know it is usually well tolerated and has potential to offer other health benefits other than just asthma relief, due at least partially to its potent antioxidant activities, its anti inflammatory effects as well as its gut microbiome manipulating effects. I further told her that the GSE should at a minimum allow her to use her inhaler less often as she was using it everyday with only minimal relief at 3 uses per day.

Research Studies

The following study illustrates how GSE may be helpful for relief from asthma by reducing airway inflammation:

Here is a relevant quote from the study:

"Nrf2-miR-29b axis is involved in the pathogenesis of severe asthma (SA). GSPE, as an adjuvant drug, maybe a potential therapeutic agent for SA."

In the following in vitro cell study, it is shown that two other potential mechanisms of action by GSE may be through reduction of mucin production and inhibition of Respiratory Synctial Virus (RSV) which is one of the most common causes of asthma :

Here is an important quote from the study :

"We found that GSP significantly decreased RSV-induced mucin synthesis at the mRNA and protein levels. In addition, GSP suppressed the RSV-induced signaling pathways, including extracellular signal-regulated kinase, c-Jun N-terminal kinase, and p38, together with nuclear factor kappa B (NF-κB) and activating protein-1 family members (c-Jun and c-Fos). Concomitantly, GSP inhibited the replication of RSV within A549 cells. Taken together, all our results suggest that GSP could be a potent therapeutic agent to suppress excessive mucus production and viral replication in RSV-induced airway inflammatory disorders."

As we continued the conversation, she told me she was going to buy the GSE that day! So we had a good visit over breakfast and she told me she would contact me later in the week after she was taking the GSE for awhile.

At the end of last week she called to say the GSE seemed to really be helping her. She first mentioned that her digestion had improved and she was no longer feeling bloated and her bowel movements were more regular, as in daily. She also mentioned that her chest congestion was clearing up, but she was still using her inhaler at two puffs, 3 times a day.

Today she texted me to let me know that her digestion feels normal, no more bloating, very regular, no chest congestion and she has not had to use her inhaler for two days!  Previously she was using her inhaler everyday. She also said, with excitement, that she feels normal again! I felt very happy for her as she said she has been feeling overall bad for over a year and now, "she feels normal again" and is very happy with the results so far! I also reminded her to keep the inhaler with her at all times just to be safe.

Grape Seed Extract Dosage for Asthma

She told me she is taking the recommended dose on the bottle of GSE. That dose is 3 capsules per day in one dose with food for a total of 1200 mg of GSE per day.

It is early days in her test of GSE for asthma and I will post if she shares any further updates with me. I wanted to share this information with the EC community because GSE is not currently listed in the EC asthma section and these are really exceptional results in a relatively short period of time even though she is relatively newly diagnosed!


Have you ever tried grape seed extract for asthma? Please send us your feedback!

About The Author

Art Solbrig is a researcher who has been reading scientific studies and testing natural remedies for over 30 years searching for useful studies and alternatives that apply positively to human health issues and natural treatments using minerals, vitamins, amino acids, essential oils, herbs, homeopathy, colloidal silver, combination treatments, and other alternatives to improve the quality of life of others by writing about his findings and test results in places like Earth Clinic. He documents and writes about many of his experiences in helping others. Art is a native of sunny California.

Related Links:

Effective Natural Remedies for Asthma
Grape Seed Extract Health Benefits

Grape Seed Extract Vs Grape Seed Oil

1 User Review
5 star (1) 

Posted by Chris (Adelaide) on 06/30/2022
5 out of 5 stars

Is there a difference between grape seed extract and grape seed oil?

Chris, Adelaide Australia

Replied by Art
1336 posts

Hi Chris,

They are not the same or equivalent. GSE possesses some of the most beneficial components of the grape vine while the oil is more like other vegetable oils and happens to have vitamin E in it. As oils go, virgin olive oil would be considered to have more healthy components than grape seed oil. Grape seed oil would not have the same positive health effects as GSE.


Where to Buy

Posted by Stephanie (Winchester, CA) on 07/05/2022

In response to Art Solbrig's new article on Grape Seed Proanthocyanidin Extract for asthma. Please can you share where I can pick up the supplement in a clean version with that high a dose? I am having trouble finding a brand that I could trust.

Replied by Art
1336 posts


I don't have a brand to recommend, but I will ask my friend what brand she used, since it worked well for her and report back once I have that information.


(Winchester, CA)

Art, thank you SO much!!! I have had asthma most of my life and things have been much worse after "the virus"... Would love to help my lungs! :) Thanks

1336 posts

Hi Stephanie,

My friend is taking Carlyle Standardized Grape Seed Extract

I find the label a bit confusing because they list 24, 000 mg per serving on the front of the label which I believe is supposed to be their idea of a non extract powder equivalent dose. On the back of the label they list 1200 mg per serving, which is 3 capsules per day, but this is the extract form. I can't say with certainty, but the 24, 000 mg number seems a bit misleading. The bottle contains 240 quick release capsules and at the recommended label dose of 3 capsules per day with food, which she is using, the bottle will last 80 days at a price of $16.99.

Here is a link to buy from :¤cy=USD&utm_medium=product_sync&utm_source=google&utm_content=sag_organic&utm_campaign=sag_organic&gclid=Cj0KCQjw5ZSWBhCVARIsALERCvzKLOo98Md7p7p7y9O4jnxsJ1PQD-xiRRXciEP7tQ3ij59dvvXQuU8aAgduEALw_wcB

Please give us your feedback if you try this product for your asthma as you are different than her in that you have had asthma for many years whereas she was only recently (this year) diagnosed with adult onset asthma. Good luck and I hope it is helpful for you as it was for her.

On a related note, she mentioned that she had a really uncomfortable "heavy feeling " in her chest. In my last conversation with her, she said that feeling is completely gone and she has not had to use her inhaler at all since she last mentioned that she had not used it for two day in a row.



I looked at the Carlyle brand and I did not like the label either, fails to mention that the extract is only 70%.

The Carlyle Standardized Grape Seed Extract is standardized to the lowest percentage of these type of products at 70% polyphenols. (280mg/400mg =70%) Better products that cost less per capsule contain 95% total polyphenols. (380mg/400mg = 95%) Look for "Min. 95% total Polyphenols" for a higher quality product IMO.

1336 posts


Thank you for the information on polyphenol content. Could you link to the product that costs less and contains 95% polyphenols? I think that would be useful for the EC community who are interested in using GSE to know.

I am not recommending the product I mentioned, just relaying what worked for my friend, to Stephanie who had asked for a recommendation that I did not have.

Thank you!


1336 posts

To update on my friend with adult-onset asthma, in her last conversation with me, she still has not required any use of her asthma inhaler and reports "feeling normal."

To add further confirmation to the idea that GSPE can be helpful for asthmatics, the following study in humans seems to have a similar line of thought :

Here is a relevant quote from the study :

>>> ' We found that the Nrf2-iNOS-HDAC2 axis was related to glucocorticoid resistance. Further studies showed that IL-8, MCP-1 and iNOS were positively correlated with severe asthma, while Nrf2, HDAC2, GSH, GCLM and Nrf2-ARE binding ability were negatively correlated with severe asthma. GSPE could relieve glucocorticoid resistance by targeting the Nrf2-iNOS-HDAC2 axis, and increased the therapeutic sensitivity of severe asthma. ' <<<


Replied by Lynn
(New Mexico)

I just read Art's article this evening and ordered a bottle. I won't mention a brand unless you ask but my go to for any supplement is Organic if possible.