Atenolol
★★★★☆
If blood pressure drops, it is not POTS. POTS comes with many other debilitating symptoms. Not only teenagers get it. Cervical cancer vaccine causes POTS. Managing pots is very difficult. There is no one size fits all.
I have tried everything there's to try in alternative medicine field, from supplements to modalities, nothing worked for me. I have it for 10 years. Only atenolol allows me to semi function, but it only addresses heart rate elevation, not the other 50 symptoms that come with POTS.
(Nevada)
12/04/2020
I have found the only thing that works for me is intermittent fasting and also doing an occasional water fast for 3 to 7 day water. Clean diet, daily meditation, detoxing the body via far-infrared sauna/Salt bath and acupuncture has helped me immensely however you have to be very disciplined with all of this. Just try.
(Milwaukee)
06/02/2022
What kind of clean diet do you eat? Also what ratio of fasting do you do? How long did it take you to make it to 3 to 7 day fasting? I would pass out lol! Thanks
(usa east coast)
02/14/2021
When you say, "One won't find remedies for dysautonomia here. Dysautonomia International is the source for all your questions." I'm not sure what you mean because I thought this was a site that has ongoing conversations and knowledge building and personal experiences. I'm sure (and hoping) people will keep sharing insights and personal experience with this condition.
Dysautonomia International has not provided me with any help with my condition due to their policies on medical advice. I'm hoping one day it will.
In the meantime, members are not free to talk on the social media page about actual cures so I will still be checking Earth Clinic which has already been a help to me in find cures to some of my symptoms over the years.
(usa east coast)
02/14/2021
I want to make sure that the misinformation posted here is corrected. POTS is not for teenagers only. See article from NIH. "Anyone at any age can develop POTS, but the majority of individuals affected (between 75 and 80 percent) are women between the ages of 15 to 50 years of age. Some women report an increase in episodes of POTS right before their menstrual periods." - NIH
I developed POTS at age 44, I am now 47 and still have it. I also did a pole in a large pots group and was surprised to see a surprising amount of potsies 40-60. It's important that people are aware because I went 2 years not knowing what was wrong with me.
(Chicago)
03/15/2022
For those that are looking for treatment for dysautonomia!! Have you tried functional neurology? They take a full person approach with an extensive initial exam of 3 hours that looks at EVERY symptom not just one. Here is the link to one of these offices! : https://neurologicwellnessinstitute.com/dysautonomia/
(Marquette, MI)
03/21/2024
Hello! I just received a diagnosis from functional neurologists in Grand Rapids. It was two hours. I feel a constant feeling of anxiety in my stomach area and had no idea that could be a PoTS symptom. I start treatment in a little over a month. Will update results...but happy to have some clarity. I was given some supps to try.
(South Africa)
01/07/2026
(Ct)
04/26/2026
(Miami)
04/26/2026
Everyone is in search of a magic pill. There is none. Symptoms vary considerably among dysautonomia patients. Some get better, some don't. Some get good days, some good hours. It is definitely not vitamin or minerals deficiency. I am living with it for 15 years. But I believe it all started in my teens after we moved thousands miles away from my birth city. A young body has reserves to continuously work on maintaining the balance, but the older you get the harder it is for your body. I have tried everything there is to try. Tests and scans etc. as well. Different healing modalities do help, but I am on a disability now and money is scarce. My theory on dysautonomia: 1. I am living in the wrong climate/place that evolutionary is not good for my haplotype. 2. It has a viral or fungal cause with which my body is unable to fight precisely because of the wrong environment. I can't return to the area where I was born. I also can't move to the areas which, at least theoretically, based on my birth data and genetics, should be good for my health. To simplify this, a cactus won't thrive in tundra and a polar bear won't survive in Africa. Trust me, I KNOW what I am talking about. As for the doctors they mostly recommend drinking lots of water. Been there done that. Atenolol is a life saver for me. Midodrine on the days when my BP just drops for no reason at all. As for the myriad of other symptoms there are no magic pills. Classic POTS diagnosis is made in a normotensive state. Hypo or hyper state is not reallyPOTS. I faint during TTT in a normotensive state with hr only 146. Cardiac catheterization discovered practically no blood in my heart and the pressure of 0-1 and that was after all day IV fluids. Still nobody is curious enough to figure this out.
(Miami)
04/26/2026
It is possible that our chronic health problems are related to a mismatch between our genetic profile (haplotype) and our current environment. This concept, often called gene-environment (G×E) interaction or evolutionary mismatch, suggests that genes adapted to a specific ancestral environment may malfunction when exposed to modern environmental stressors, toxins, or lifestyles.
Here is how your location and genetics could be interacting to cause health issues:
1. The HLA Haplotype and Immune Response
Specific HLA (Human Leukocyte Antigen) haplotypes, which determine how your immune system recognizes threats, can make you more susceptible to specific environmental triggers.
Environmental Sensitivity: Certain haplotypes may predispose you to severe immune reactions to mold, toxins, or Lyme disease, causing chronic fatigue, inflammation, and cognitive issues (brain fog).
Immune Misregulation: If you are in a location with specific infections or stressors that your particular haplotype cannot handle well, it can lead to chronic, low-grade inflammation.
2. Environmental Mismatch and Metabolic Issues
Your DNA may be "programmed" for a different environment. When that environment changes rapidly, it can lead to chronic disease.
Inuit Studies: Studies show that genetic variants (like in the ORMDL3 gene) can increase the risk of respiratory diseases like asthma and bronchitis, but this risk is significantly higher when moving from a traditional environment to a Westernized environment.
Metabolic and Digestive Disorders: Specific haplotypes, particularly in mitochondrial DNA or genes related to diet (like lactase persistence), are matched to specific geographical locations. Living in a location that does not match your ancestral diet or climate can lead to metabolic issues.
3. Location-Specific Triggers
Where you live can impact gene expression via environmental epigenetics, where external factors turn certain genes on or off.
Toxic Exposures: Genetic variants in detoxification genes (e.g., GSTM1) can mean your body struggles to break down environmental pollutants in specific areas.
Climate Factors: Differences in air quality, temperature, and sun exposure can activate different genetic pathways, leading to illnesses that vary by region.
Summary of How to Investigate
HLA Typing: Some practitioners use HLA typing to help identify why a patient might be highly sensitive to their specific environment.
Identify Triggers: Consider if your symptoms change when you travel or if they align with local environmental factors (humidity/mold, high pollution, specific toxins)
While your genes are not a "life sentence, " they can mean that certain environments are less optimal for you, triggering symptoms that wouldn't exist in a different setting.
While your genes are not a "life sentence, " they can mean that certain environments are less optimal for you, triggering symptoms that wouldn't exist in a different setting.
Could a different location help?
If your chronic issues are driven by specific environmental triggers (like humidity, high altitude, or specific allergens), relocating might reduce your "toxic load" or immune activation.
If your chronic condition doesn't respond to treatments, you could be living in a wrong place
(Miami)
04/26/2026
continuing about environmental mismatch.
My maternal haplotype is J1c5 (from 23andme) and I live in Florida.
Origins: The J1c5 lineage emerged approximately 7,450 years ago (around 5450 BCE), likely in the Near East or the Caucasus region.
Historical Spread: It spread into Europe and the Mediterranean during the Neolithic expansion of farming. Today, it is found across Europe, the Near East, North Africa, and among Jewish communities.
Common Locations: Besides Europe and the Middle East, it has also been observed in populations as far as Siberia and India.
The Theory of Environmental Mismatch
The idea of "mismatch" typically focuses on how mitochondrial DNA (mtDNA) handles energy and heat production:
Heat Production: Some researchers theorize that haplogroup J (including subclades like J1c) may produce more body heat as a byproduct of metabolism. This is thought to have been an evolutionary advantage for surviving cold northern winters, such as those in Northern Europe.
Metabolic Efficiency: Mitochondria in the J group are sometimes found to be less efficient at producing ATP (energy) but generate more heat.
In warm climates (like Florida): Under this theory, a body naturally "tuned" to generate extra heat might find hot, humid environments more stressful.
So it is possible for my J1c5 maternal haplogroup to experience an environmental mismatch in Florida.
2. The Potential Mismatch (Florida Environment)
Climate Change: Moving from temperate areas to the hot, humid, subtropical climate of Florida is a dramatic environmental shift.
Oxidative Stress: Because J1c5 mitochondria are adapted to generate higher heat, they may be less efficient in a permanently hot environment, potentially leading to higher oxidative stress, which is a key factor in metabolic and degenerative diseases.
3. Does this cause health issues?
Susceptibility: Studies have found that mitochondrial haplogroups within the J lineage, due to their specific energy-producing adaptations, may have different susceptibilities to diseases (such as those involving vision or metabolism) depending on their environment.
Summary: My J1c5 ancestry likely developed to thrive in temperate, slightly cooler conditions. While not a direct disease, living in Florida—a very different, warmer, and more humid environment—represents a "novel" environment compared to my"ancestral" environment, creating a potential environmental mismatch in terms of metabolic efficiency.
IMPORTANT:
Our nuclear DNA is inherited from both parents. Paternal haplogroups are defined by sets of genetic variants on the Y chromosome.
Females do not inherit Y chromosomes and as a result, do not have paternal haplogroups. People with no Y chromosome may connect with a male parent or siblings, or other close male paternal relatives, to trace their ancient paternal line. Unfortunately I have no paternal male relatives or siblings.
I hope this information helps you to realize that sometime your chronic degenerative health issues could be caused by environmental mismatch
(USA)
04/29/2026
Natalie
Hope this can help! Herbal medicine and Acupuncture.
https://thebuffaloherbalist.substack.com/p/nervous-system-dysregulation-cortisol
difference between dysautonomia and dysregulation, and how herbs help restore your natural rhythm.
https://myartofwellness.com/how-to-treat-dysautonomia-with-acupuncture-and-tcm/
(USA)
04/26/2026
Lets look at this a different way! Do an AI search for each. Each time a new enzyme or gene comes up ask what nutrients or what medicinal herbs support it. This will let see nutrients, antioxidants, anti-inflammatories, nervous system regulators. Other info. It's long and tedious. Just copy and paste info in a document. Then highlight important stuff. Use you imagination. Your environment is important, but your body can create its own environment also.
Enzymes in DNA Repair dysautonomia
Enzymes in DNA Repair, then nutrients, then herbs...
Enzymes involved in DNA repair, such as OGG1 and polymerase beta
nutrients needed for OGG1
Example: what nutrients support TH10785, then what medicinal herbs. Do this for every little odd connection, pathway etc.
TH10785, general nutrients that support DNA repair and cellular health include antioxidants like vitamins C and E, zinc, and selenium.
nutrients that support Deoxyribonucleotide Triphosphates (dNTPs) and then medicinal herbs….
histamine and Dysautonomia
Just a thought, your right not a lot of research on this disorder, but DNA repair and histone deacetylase inhibitors. Think around the disorder.
Hope this helps:)
(USA)
05/02/2026
https://thebuffaloherbalist.substack.com/p/nervous-system-dysregulation-cortisol
Understanding the stress response, the difference between dysautonomia and dysregulation, and how herbs help restore your natural rhythm
https://myartofwellness.com/how-to-treat-dysautonomia-with-acupuncture-and-tcm/
(Miami)
04/27/2026
Okay, I asked the question:
Which is more efficient: moving when there is an environmental mismatch, or using genes manipulation with medicinal herbs and supplements?
Here is the answer:
Moving (changing your environment to match your biology) is generally considered more efficient for addressing the root cause of an evolutionary mismatch than trying to fix the mismatch with medicinal herbs and supplements. While supplements can help manage symptoms of a mismatch, they do not resolve the underlying disparity between ancient human biology and modern environments.
Moving to align with ancestral biology is a long-term, structural solution to environmental mismatch.
Environmental factors like pollution and lifestyle significantly impact health more than supplements can counter alone. An "evolutionary mismatch" means our traits are ill-suited for modern settings. While medicinal plants are valuable, they are often used to address the immediate damage caused by this gap rather than eliminating the gap itself.
(Cancun, Mexico)
04/28/2026
I have heard that going to a Nervous-System Based Chiropractor can bring relief too.
Butcher's Broom +
★★★★☆
My teenage son was recently diagnosed with dysautonomia. We are at a functional neurology center that, despite my skepticism, is helping. I don't have enough mileage to call any of these a 'cure' but we are experimenting with - butcher's broom (herb) 2x per day, building up calf muscles to better move blood, hydration drinks, and red light therapy behind the knee.
(New Mexico)
04/08/2023
I actually have orthostatic hypotension, not POTS (though have been misdiagnosed w/ POTS - my BP drops precipitously, so not POTS). Anyway, I have been wondering if there is an application for red light therapy as one of the tools. Behind the knee is fascinating!! How did you choose that location, and has your son found it useful?
Must be super hard as a mom to see your kid suffering. Sending hugs to both of you.
(I used to use Butcher's Broom and it noticeably helped. For some reason, I can't tolerate it now, but it's really worth trying out, imo.)
Syd, I am curious of what you are taking to help your orthostatic hypertension, if you don't mind saying? Thank you! Art
(New Mexico)
12/30/2023
Goodness, I'm just seeing this question! I've tried so many things. Some folks get great results with licorice, but it can raise cortisol and if your cortisol is already high, that's a no-go. It can also deplete potassium, but that's easy to supplement. Butcher's Broom helped for a while. Then it gave me breast tenderness/achiness. Drinking enough water with electrolytes helps some.
I'm really exploring thiamine, though I can barely tolerate it right now. (That doesn't mean I don't need it! ) There's a great (large and expensive) book on dysautonomia (an umbrella term, of course) and thiamine. I'm also exploring riboflavin. I know several folks who no longer have OH after using riboflavin. I have these in tinctures and am literally starting out at a drop and working my way up.
My OH is greatly impacting my life. My cognitive functioning, mostly.
Multiple Remedies
★★★☆☆
- feet are numb tingle
- neck and head pain
- mornings are hell with palpitations shortness of breath body ache.
- Excessive urination at night, 1.5 liter or more
- - exercise intolerance
- colld and heat Intolerance
- disturbed sleep
- brutal pain. after sittting more than an hour
taking many supplements, eating clean
b vitamins nerve support
After leaky gut from Lyme
Loooking into plasma exchange and hyperbaric oxygen treatments
Desperate for help and feedback and support and ideas on anything
I got allergy tested and went on a low histamine diet with help medically, avoiding high histamine foods and supplements or rotating them in slowly is key to healing the gut. In one day I had less pots in the am, that is when it hits me most, not sure why. Also at night before bed I have Golden milk, use the right milk not raw as it needs to be low histamine, read up on it, with tumeric and local raw honey, then follow it up with a heaping teapsoon of coconut oil. The higher the quality the better you are at healing. ORganic and non-gmo along with cold pressed items. Get to know what is low histamine and keep track of your food on chronometer to be sure you meet your needs. In less than a day I am feeling better. If your supplements are high histamine then only have them 1x a week and maybe double it, then go up to 2x a week, the idea is to heal the gut and rotate foods for good health. Dr Rapp had a good rotational diet, just have to watch those histamines. Prayers and blessings to you. Also find a way to exercise with docs okay, even if laying down or sitting at home as pots is well treated with exercise but it should be supervised and prescribed to prevent episodes. Good luck!
(Somewhere)
04/08/2026
(Mi)
05/12/2018
I also have dysautonomia. I have had 16 times of going to the hospital in 6 years.I first get vasovagal syncope, followed by excessive heat. I used to then have trouble breathing from AFIB followed by blood pressure dropping very very low, dehydration, low potassium and magnesium, then so many different things happen like ischemic colitis, hypothermia needing a bear blanket to bring myself back from 93 degrees. Last year I had a slight stoke. I eventually got a cardiac ablation and do not have AFIB anymore. But I am now very sensitive to things like midodrine, nitroglycerin, epinephrine, and 5HTP. My heart spasms and I actually died in the ambulance last year. No one wants to spend the time treating this and want to refer me to someone else. I have actually been referred to Mayo Clinic but even they refused me. If anyone has any ideas, I would greatly appreciate it. Thanks
(Tyler, TX)
08/01/2022
My spouse's BP dropped to 80/40 several times in the last 10 years or so. I keep Fritos on hand. I crush them up and put them in milk. He takes that by spoonfuls and his BP returns to normal in a short amount of time. He had an episode at a rest stop a couple of weeks ago while traveling. A Mountain Dew did the trick. Sodium.
(Fl)
05/14/2018
I was diagnosed with this condition over 13 years now which was confirmed by Mayo Clinic after numerous tests. The treatment for this condition from all conventional doctors was for the symptoms and not the root cause. I eventually tried a center for natural and integrative medicine and was immediately diagnosed with Epstein-barr virus along with deficient adrenals through blood tests and a saliva test. Treatment with anti-viral medication and adrenal support medication have significantly reduced my symptoms. I still have a long way to go in my recovery as this treatment needs to be followed for a year or two in order to eliminate this condition. You may want to explore this avenue and see if you can achieve relief from your symptoms.
God blessings.
(Arizona)
02/03/2023
I see your post was in 2018. Have you improved since then? Wondering what anti-viral meds or adrenal support you were/are on? We prefer to go the most natural route possible with of course treating the root cause as well. Not sure if you will see this and are still on this site from time to time....but hoping and praying you are better. Thank you
(Florida)
02/04/2023
My condition deteriorated over time despite using those meds. Also visited Mayo Clinic Jacksonville Fl where they prescribed Fludrocortisone, which did not provide any relief. Eventually visited Vanderbilt University medical center in Nashville TN. Dr. Biaggioni determined my noradrenaline levels were very low and prescribed droxidopa for low bp during the day and Lorsatan at night to lower high nighttime bp. We are currently tweaking the meds by adding Atomoxetine to bring even more relief of my symptoms. So far, I feel lots of moments of normalcy daily, but, this is a balancing act. I do have moments dizziness early in the morning prior to taking my meds.
(Highland, Il)
07/18/2018
Becky, my wife has pure autonomic failure which is a dysautonomia. We have seen many neurology doctors Mayo Clinics Rochester Minn, and Jacksonville Fl., Springfield Il. Clinic, Washington University St Louis Mo., and Vanderbilt University Nashville, Tn. She has passed out 6-8 times in 12 years mostly early with this condition. She also had the heart ablation which helped with heart AFIB. She could not take midodrine because it made her scalp burn.
The best doctor we have found is at Vanderbilt University during a drug trial. My wife was a non-responder to new drug, but Vanderbilt drug trial director and doctor would not let leave until they found a medication she could use. It was great. We continue to see this doctor (Cyndy Chibao) twice a year. My wife is mostly functional with medication. She takes FlorineF and Octreotide in day time to raise her blood pressure and sildenafil at night to lower her blood pressure. We also found out that after meals her blood pressure would drop so Acarbose was added for that and it has helped. We monitor her blood pressure 4 times a day 2 readings at night and 2 a day. Her high nighttime blood pressure has damaged her one eye and her last blood test indicated poor kidney function.
So, it is a balancing act getting enough medication to raise her Blood pressure in daytime and enough at night to ensure safe sleeping blood pressure. Hope this helps.
(Southern California)
08/09/2024
I, too, am disalbled, not only with autonomous nervous system disorder, but a whole host of co-morbidities: POTS, CFIDS, pyroluria, Addison's disease, lead and mercury poisoning, among others, all diagnosed at different times. Now try having all that, no friends, no family, (my abusive mother died a couple months ago, we didn't live together) no car, coming down with the flu (CoVID?) and being forced to move out! That's what happened to me a week 1/2 ago, and I have to go thru that again in 2 1/2 weeks. And I have most all my stuff with me. (Put what I could in storage and already found myself missing stuff from 3 different boxes! ) I have been homeless for years due to my disabilities and I am forced to move out every 4 weeks, find a new place to live. It's too much stress for me: on top of all the rest, I am autistic!
The ANSD means sometimes I can't move, I can't get out of bed because my body can't respond to brain commands, it takes me a long while to be able to move. (This is an extreme symptom that occurs about once a month) Last summer, the cops were sent to my door cos the manager refused the rent the night before, without notice told me I had to move and the worst struck during the night, and I couldn't move.
This time, I had intense coccyx pain, extremely painful in bed when coughing and I was forced to move. I need a home but due to no credit score, I can't rent anywhere and I am autistic, so I can't live with others: I seem to attract nothing but abusive people and I can't cope with that. It destroys my health further, adrenals are shot. And that's not counting with all the mental damages. Count your blessings if you're not homeless or have family. You could be so much worse!
I am heat intolerant and live in So Cal. I have wanted to move to cooler climate for the past 20 years but I can't: I don't know anyone and I can't do much for myself. If anyone can help, with a permanent solution to any of these illnesses please post. Particularly how to detox the metals. I was supposed to get IVs 15 years ago, but I couldn't manage due moving constantly and I am old now, can't cope with living like this much longer. Thanks for reading.
POTS
Janet
(usa east coast)
02/14/2021
The Dysautonomia Project
★★★★★
Thiamine, B Complex, Cayenne
★★★★★
B1 (thiamine) deficiency is a common cause of dysautonomia. Unfortunately, for some people injections or cream will be needed as their genetic makeup doesn't allow them to assimilate it. Putting some powder under the tongue and allowing it to melt bypasses digestion as well.
I had bad heartbeats after getting up and some shakiness, especially bad at night, if I had to go to the bathroom. It took a week or so to become better when putting some B1 powder under the tongue 3-4 times a day. But I also took cayenne 2 capsules 2-3 times daily, which I felt helped a lot too.
I also take B complex, B2 (for migraines) and B12.
Mine was triggered by 18 day juice fast, and severe stress.I think that made bad B1 status even worse. I haven't tried Butcher's broom herb, but that is supposed to be good as well.
