The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.
Grape Seed Extract Side Effects
Posted by Sarah (Toledo, Ohio, United States) on 02/12/2013

I'm currently six months post partum and decided to start taking Grape Seed Extract for general health and younger looking skin. I was told to take 1mg for each pound I weigh (120lbs/120mg). The pills are 100mg each, so I was taking two a day with the understanding that excess would be excreted through urine. That day I started having heart palpitations, severe night sweats and anxiety/depression spells. This continued for two weeks (I thought it might be an adjustment period) before I reduced to one pill a day (100mg). The issues continued. I then stopped taking the GSE and all symptoms disappeared by the next day. I waited a week and tried it again. All negative symptoms came back in full force. In all my research on the internet, I'm not finding anyone with any issues like this regarding grape seed extract. I have two theories regarding my reaction and wanted to hear everyone else's feedback.
1. I'm thinking I might have post partum depression and the grape seed extract is amplifying it.
2. I had an epidural and petocin during my labor and my body is reacting poorly to all those drugs leaving my system.
These are merely guesses.
Age: 32, Weight: 120, good general health - no diagnosed issues, moderate exercise and a fairly healthy diet consisting of many fruits, vegetable, minimal meat and minimal processed foods. I do have alcoholic drinks almost every night (typically 1-3).
Thanks all!
Grape Seed Extract Side Effects
Posted by Snowbell (Minneapolis, Mn) on 07/09/2013

Just wondering if you ever tried taking Grapeseed extract again. I have had some anxiety issues with possibly Grapeseed extract as well but never find anything online when I try to research.
Fibroids
Posted by Janice Gilliard (Tampa, Fl) on 02/20/2016
I'm trying the grape seed extract this month. I have fibroids and have tried everything I've read it heard about on the t.v. or the dr shows. I'm expecting the miracle also. I'm tired of going through 2 packs of over night pads in 3 days of my 5 day cycle. How I long for that lighter 3 day cycle. Thanks for sharing
Heavy Menstrual Bleeding
Posted by crystal (any town, United States) on 04/23/2008
★★★★★
I tried grapeseed extract for menstrual flooding associated with fibroids. I took 3 - 90 mg tablets 4 times a day and my menstrual was the closest to normal it's been in years. Also mother tried it for the same problem and was well pleased! I am happy!
Grape Seed Extract Side Effects
Posted by Paula (Montreal) on 02/03/2016

I started taking Grape Seed Extract recently and soon afterward began having anxiety (which is not usually a problem for me in the same situations I am currently in), heart palpitations that I thought would never end on some days and when there were no regular heart palpitations it felt like there was congestion or rumbling in my chest (similar to what I might have felt if I was congested with bronchitis).
I didn't link it to the Grape Seed Extract right away, but after a week or so I stopped taking it and within 36 hours I was back to how I usually feel. I waited a few days and took it again, and that day and into the next the symptoms were back so I won't be taking it anymore.
Grape Seed Extract Side Effects
Posted by Sarah (Toledo, Oh) on 02/14/2013
Tim, thank you for your suggestions. Rosanne - It is Grape seed extract I was taking.
Grape Seed Extract Side Effects
Posted by Octagon (Chicago, Illinois) on 02/28/2013
You may have gotten hold of a contaminated batch. Perhaps trying another highly rated brand would make a difference.
UTI
Posted by Lynn (California) on 03/26/2023 5 posts
I'm wondering if the original poster meant grapeFRUIT seed extract for UTI?? GSE is used for both Grapeseed Extract AND GrapeFRUIT Seed Extract but they are two different things. GrapeFRUIT Seed Extract is antibacterial so it would make sense that this is what was meant and not Grapeseed Extract. I'd research both and make your decision. I just wanted to bring this up in case someone sees it and may purchase the wrong thing. They are easy to confuse.
MRSA
Posted by Kat (Gj, Co) on 01/05/2014
Hi Jim,I wanted to post the link for citation. Thank you for alerting us to it. I will definitely look into it more!!
Grape Seed Extract Side Effects
Posted by Rosanne (Toronto, Canada) on 02/14/2013
Are you using Grape Seed Extract, or Grapefruit Seed Extract? They are two different things.
Hay Fever, Food Allergies
Posted by Sheri (Texas) on 05/25/2025
What kind of food allergies did you have? What foods did you have to avoid?