Nattokinase's Role in Effectively Treating High Cholesterol

Don't miss Art's latest update on using nattokinase, including his incredible lab results in 7 months.

https://www.earthclinic.com/cures/nattokinase-benefits-high-cholesterol-treatment.html

Thank you, Art!

Hi Sheila,

The only study done for lecithin and cholesterol that I am aware of used soy lecithin and that is what I have used and seen work. If the lecithin in water is not your cup of tea, I suggest you consider this as a very good alternative :

https://www.earthclinic.com/cures/high-dose-nattokinase-for-atherosclerosis.html

And also this :

https://www.earthclinic.com/cures/nattokinase-benefits-high-cholesterol-treatment.html

These should not only lower cholesterol, but significantly improve atherosclerosis, which is actually what doctor would like to do.

Art

Queen Bee,

Keep in mind that the nattokinase was quite effective by itself in the study. Yes, the K2M7 at 190 mcg/day was additive, but the solo results of nattokinase were still impressive.

If you are chelating heavy metals and can't make your regular chelation appointments, you might look into melatonin as a protectant to help reduce the heavy metal damage in between chelation treatments. Melatonin also helps prevent atherosclerosis via its potent antioxidative qualities as well as its vascular anti inflammatory qualities. This of course would be based on whether you tolerate higher dose melatonin or not.

Art

High FU Nattokinase

So glad I got the notice of this article today. I ordered the best nattokinase I could find ~ organic and high FU count for my thick blood and clots (of course, not wanting to take blood thinners as they give me a headache).

So yesterday, I found out I have very high cholesterol and triglycerides from my doctor and she wanted to put me on statins. (which I wasn't comfortable with).

Your report is exactly what I needed. I just received my Nattokinase.
If you're looking for organic and high potency FU nattokinase, I ordered 500 grams of Organic (made with organic soybeans from Brazil) 20,000 FU/gram powder from VitaMondo (it takes about a month to get it) at apx. $73. (way less expensive than buying that much premade, low potency capsules)

I am going to make my own capsules, they should be enteric coated (so they dissolve in the small intestine to get absorbed, not the stomach (acid) where they would just act like a normal enzyme).

I figured out to get 10,800 FU per day (1 cap 2x day/morning & evening) you would put 270 mg in each capsule (.27 grams each).

I look forward to taking for 6 mos and seeing my test results for differences.

P.S. - I am sharing the order with a couple friends one with blood clots and severe atherosclerosis, because this amount will last a good long time (taking just over 1/2 grams per day)

RedCardinal,

Please come back and let us know how you do on high dose nattokinase! Keep in mind that the original study showed that vitamin K2M7 had synergy with the nattokinase and my experience suggests that the grape seed proanthocyanidin extract (GSPE) does too. I take all three and found it very effective for the purpose.

Art

Hi Sheila,

Given the proven benefits that nattokinase has shown in terms of reversing the trend of atherosclerosis in humans, its value needs to be weighed in comparison to Eliquis. Eliquis is an anticoagulant that has bleeding as a common side effect as discussed here :

https://www.drugs.com/eliquis.html#side-effects

Nattokinase can also thin the blood and dissolve blood clots as discussed here :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5372539/#:~:text=Nattokinase is considered to be, blood and dissolving blood clots.

Here is a relevant quote :

' Nattokinase (NK), a potent blood-clot dissolving protein used for the treatment of cardiovascular diseases, is produced by the bacterium Bacillus subtilis during the fermentation of soybeans to produce Natto. NK has been extensively studied in Japan, Korea, and China. Recently, the fibrinolytic (anti-clotting) capacity of NK has been recognized by Western medicine. The National Science Foundation in the United States has investigated and evaluated the safety of NK. '

If your doctor is willing, he/she may temporarily allow you to stop Eliquis to test nattokinase or reduce your dose of Eliquis so you can use nattokinase simultaneously. The reason I am mentioning nattokinase to you is because I feel it is actually stopping CVD at its most common source, atherosclerosis. Whereas, Eliquis is mainly treating symptoms such as clotting and people can still have stroke while taking Eliquis as discussed in the following human study :

https://j-stroke.org/upload/pdf/jos-2021-02355.pdf

Here is a relevant study quote :

' A total of 651 patients (mean age, 72.5±8.7 years) received apixaban for a mean duration of 82.7±37.4 weeks. Fifty-three bleeding events occurred in 39 patients (6.0%), and 10 (1.5%) experienced major bleeding. Seventeen patients (2.6%) had major events (stroke, n=15, 2.3%; all ischemic), systemic embolism (n=1, 0.2%), and death (n=3, 0.5%). MRI data showed no significant association between white matter ischemic changes and microbleeds, and major events or bleeding. Patients with cerebral atherosclerotic lesions had a higher rate of major events than those without (4.6% [n=10/219] vs. 1.7% [n=7/409], P=0.0357), which partly explains the increased prevalence of major outcomes in this group versus patients without stroke (0.7%, P=0.0002).'

See if you can find data suggesting that Eliquis can change the trend of atherosclerosis, which is usually the underlying problem. To give you an idea of what I am talking about, look at this study using just grape seed proanthocyanidin (GSPE) :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554789/

Here is a relevant study quote :

' As anticipated, after treatment, GSPE resulted in significant reduction in MMCIMT progression (4.2% decrease after six months, 4.9% decrease after 12 months and 5.8% decrease after 24 months) and plaque score (10.9% decrease after six months, 24.1% decrease after 12 months and 33.1% decrease after 24 months) for the primary outcome, while MMCIMT and plaque score were stable and even increased with the time going on in control group. The number of plaques and unstable plaques also decreased after treatment of GSPE. Furthermore, the carotid plaque can disappear after treatment with GSPE. The incidence rate for transitory ischemic attack (TIA), arterial revascularization procedure, and hospital readmission for unstable angina in GSPE group were statistically significant lower (P = 0.02, 0.08, 0.002, respectively) compared with the control group. '

Here is a graph that gives a great visual representation of what this relatively low dose of GSPE did in this study to significantly alter the atherosclerotic trend from upward to downward :

If Eliquis could produce these same effects as GSPE while acting as an anticoagulant, that would be useful, but I can't find any data that shows that it does. If you can find such data, please share it with me. This is a major reason why I use GSPE myself. It is also worth mentioning that while GSPE can have a significant effect on on carotid plaque and plaque score, its effects on cholesterol levels are minimal.

Doctors will tell you that statins can help atherosclerosis, but statins mainly slow progression of atherosclerosis. Statins only reduce the chance of having a heart attack by 25% to 35% as discussed in this Harvard article :

https://www.health.harvard.edu/heart-health/one-in-five-people-at-risk-of-heart-disease-shuns-statins#:~:text=Cholesterol-lowering statins can reduce, common, life-threatening events.

Here is a relevant quote from the article :

' Cholesterol-lowering statins can reduce the odds of having a heart attack by about 25% to 35%, especially in people at high risk for these common, life-threatening events. '

That means that 65% to 75% of people taking statins still have the potential for a heart attack.

I believe that cholesterol is a poor marker for atherosclerosis because many people with good cholesterol levels still have heart attacks as discussed here :

https://www.cardiosmart.org/news/2017/12/half-of-patients-with-ideal-cholesterol-have-underlying-heart-risks#:~:text=Optimal cholesterol levels don't, build-up in their arteries.

Here is a relevant article quote :

' Optimal cholesterol levels don't always translate to perfect heart health, based on a recent study that found half of healthy patients with normal cholesterol levels have dangerous plaque build-up in their arteries. '

Altering the atherosclerosis trend from upward to downward makes sense since atherosclerosis is the dominant cause of cardiovascular disease which includes strokes and heart attacks among others. Cholesterol does not seem to be a great marker for atherosclerosis, but atherosclerosis is a very good marker for CVD.

Art

Hi Deb,

Thank you for reiterating the importance of CoQ10 for our health, especially at higher dosage levels!

I could definitely have worded that better, because I did not mean to dismiss the potential health benefits of CoQ10/Ubiquinol. They are real and that is why I was and still am taking higher dose ubiquinol. I only meant to point out that if the reason you are taking it is to lower LDL cholesterol and triglycerides, you will likely be disappointed in your results.

Art

Sheila,

I can't speak to the issue of "the myth of high cholesterol", but if you want to lower your cholesterol, the study I linked to in the first article suggests that nattokinase can help in that endeavor.

Your cholesterol levels seem elevated based on what is currently considered normal levels. For total cholesterol (309), below 200 mg/dl is considered acceptable. For LDL(203), below 200 is considered acceptable. For HDL (56) above 40 mg/dl is considered acceptable. For triglycerides(249), below 150 mg/dl is considered acceptable or normal. For VLDL, 2 to 30 mg/dl is considered the normal range.

CABG helps restore blood flow for the heart, but it is not a cure for atherosclerosis, so you still have to deal with the atherosclerosis that clogs the arteries in the first place.

I do not believe cholesterol levels are the most accurate indicator for atherosclerosis, but it is a lot less expensive of a test than to actually test for atherosclerosis and many insurance companies may not be willing to pay for actual atherosclerosis testing.

Imo, the fact that you needed a CABG suggests that you have established atherosclerosis.

For myself personally, because I don't want to use statins to control cholesterol levels, I am using nattokinase with vitamin K2M7 and grape seed proanthocyanidin extract(GSPE) successfully for that purpose. It isn't the only way to lower cholesterol, but it is what I chose to use and I believe that these supplements offer other potential health benefits. Statins are thought to "slow atherosclerosis progression", but I believe the three supplements I use alter the trend direction of atherosclerosis from upward to downward as illustrated by this study chart where GSPE was used in people with atherosclerosis :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4554789/

Keep in mind that this chart is for GSPE all by itself, not including K2M7 or nattokinase.

Art

Hi Hollyhock,

If you go to their website :

https://www.xtend-life.com/blogs/supplement-ingredients/nattokinase

apparently they are not the same. They claim that their product contains enzymes that have similar effects to Nattokinase, but they offer no human testing to confirm or support their claims. Here is a quote from their site :

' Nattozimes® is specifically formulated to be a more effective alternative to nattokinase. It's a protease system with the same activity as nattokinase in the laboratory, known scientifically as its in vitro activity. '

This statement makes no mention of any type of heads up study utilizing Nattozimes and Nattokinase in humans to support their idea that Nattozimes are superior to Nattokinase. All they have is a report of how they compare in a test tube. Test tube results are not the same as actual results in humans.

I will stick with nattokinase since it does have several studies to support its effectiveness in humans.

Art

Hello Art,

Please don't dismiss the importance of coq10 or ubiqionol. My daughter recovered from postpartum cardiomyopathy. She took a minimum of 800 mgs a day, along with other supplements. I know your article is about cholesterol, but people may get the wrong idea about the use of coq10. Thank you for your article! I'm taking all of the ones you suggested.

Hi Art - I have been reading your posts about granular soy lecithin. My numbers are high, and I have had success doing the following. I have been taking lecithin, food-grade orange oil, and borax...it's Ted's regimen. I am taking sunflower lecithin - soy-free. I mix the soy powder with water and the borax and orange oil. These are my questions: Is one form of lecithin better than the other? And, could I mix these 3 ingredients in a smoothie, or will that weaken their effectiveness? It's been weeks now, and I am struggling with getting the water mixture down faithfully. Thank you for your time, and I look forward to reading your reply. Sheila

Thank you for your reply. I should have stated that I am on Eliquis due to a TIA. Also a low-dose aspirin. I have been told not to take nattokinase.

Hi Lonnie,

I'm glad you enjoyed the article!

You may have missed this link to a Cleveland clinic article discussing VLDL (very low density lipoprotein) in the article, but it is pretty straightforward in showing that you want to keep this bad cholesterol form as low as possible because it is a definite contributor to atherosclerosis:

http://https//my.clevelandclinic.org/health/articles/24540-vldl-cholesterol

Low density lipoprotein (LDL) is often the focus when referring to bad cholesterol, but VLDL is also important!

Non HDL cholesterol encompasses all of the bad cholesterol, so once again, going lower in the reference range is generally better for our health. This is the reference range for non hdl cholesterol:

https://www.mayoclinic.org/diseases-conditions/high-blood-cholesterol/expert-answers/cholesterol-ratio/faq-20058006#:~:text=An optimal level of non, by your HDL cholesterol number.

A relevant article quote :

' An optimal level of non- HDL cholesterol is less than 130 milligrams per deciliter (mg/dL), or 3.37 millimoles per liter (mmol/L). Higher numbers mean a higher risk of heart disease. '

Art

Thank you Art! I will finish up this bottle, there's only a third left. I will try to find the higher strength nattokinase. I usually buy my supplements from Ih..b, but they don't seem to have the better strength. Looking forward to the great benefits of natto!

Hi Lora,

Yes, dose seems to be very important in the effective use of nattokinase. In the original study it was shown that while 10, 800 FU/day of nattokinase was effective, 3600 FU/day was not effective.

In that study it was also shown that vitamin K2 had synergy with nattokinase in terms of lowering cholesterol and triglycerides and ultimately atherosclerosis.

Nattokinase has shown some potential to have blood thinning qualities while vitamin K2 is involved in part of the clotting process. Your doctor would have to advise you on this issue. I am only reporting the study results as well as my results with what I used. I would think your doctor would be willing to be a little flexible with you, given that his/her regimen has not yet been effective for you. You would need your doctor's approval and supervision in order to help insure a safe path forward for you as well as compatibility of all components of whatever you decide to use.

Art

Hello Art

I'm still under educated when it comes to cholesterol and bringing my numbers down. My numbers are not bad but I could bring my LDL's down. I just do not want to go on synthetics and my doctor is pushing it on me. I told him I would bring my numbers down. He told me to stop eating eggs and coconut based foods. For about 5 years I have always tried to reason with him about my coconut intake. He is old school and unfortunately I can not just go out and get a new doctor with my insurance plan.

Here are my numbers and I'm well aware you are not allowed to diagnose but I do have questions in regards to NK and how to take it properly. I did order the Arthur Andrew Supplement and for the last week have been taking 3 capsules about an hour after taking my thyroid prescription.

• HDL: 97
• LDL: 112
• VLDL: 8
• TRIGLYCERIDES: 47
• TOTAL CHOLESTEROL : 242

I'm curious how one should take the supplements. Roughly 3 equal the amount needed for NK to work, so does one take these all at once, or can it be divided throughout the day?

It also seems taking high doses all at once can upset the intestines, which is not fun. I'm also wondering, when it suggests taking on an empty stomach, how long one needs to wait to eat.

Since my cholesterol is high, it has affected my TSH (5.82) and its out of range and so is my Glucose levels (103).

My Endo upped my Armour Thyroid from 30mg to 45mg 3 times a week to try and normalize it.

I need to take my Armour Thyroid on an empty stomach and wait an hour before consuming foods.

My confusion really is, since I cant take NK with other supplements/prescriptions, and need to take on an empty stomach, I need to go about 2 hours after waking to not eat?? It's already overkill waiting an hour.

My other question is, how long does one take NK for? Do you stop taking high doses once your numbers go down, or stop taking for a period of time or is this like taking medication that you need to take them every day to maintain?

Armour Thyroid is the only prescription medication I am on.

I do take an array of other supplements including a high quality fish oil.

I do have one more question and below, I will recap them so they don't get lost in my message post.

Thank You!

• If you are taking 3 NK supplements to equal about 10,000 FU, do you take them all at once or can it be divided?
• How long to wait to eat or take medication after taking doses of NK?
• How long does one take NK for?
• Do you need to change your diet completely like give up eggs. I mean eggs with yolk.

Hi Art, I enjoyed your article. The last two lab results you posted on always confuse me. I have asked my provider what they mean, and they dismiss my questions and just say, lets watch it. Can you bring more clarity to VLDL and Non-HDL?

Thanks!

Thank you, Art, for all your wise advice. I had a CABG in 8/23. I am recovering from that surgery nicely. However, it seems that I have other "problems" that have since cropped up. I now have elevated cholesterol. I am so reluctant to take any statins. My numbers are: Cholesterol 309, Triglycerides 249, LDL 203.20, VLDL 49.8, HDL 56, and cholesterol HDL ratio 56. I'm not sure if I need to be concerned about my numbers. I have read a lot about the "myth" of having high cholesterol and it being a bad thing. And the VLDL thing is completely new to me. But....I am admittedly nervous and don't completely trust my doctor's interest in my case. She seems very ready to give me another pill. I have been taking Ted's advice about cholesterol and using granulated lecithin and d-liomene 3x daily. But....haven't been doing it for a many days. And not always regularly. Any thoughts and wisdom would be very appreciated.

Are nattozimes the same as nattokinase?

I bought a bottle of nattozimes (made by Swanson) thinking it was the same as nattokinase last month. The strength is 195mg (6750 FU). I decided to go ahead and try them out. Not noticing much yet, I did notice the milia around my eyes have gone away. I will then probably next time get the real nattokinase that you suggested in the highest strength. Hoping for more mental clarity, heart, blood clots, circulation, bone health, eye health, liver, etc. It says it has the same enzimes as natto. Anyone tried this brand? Thanks

I have had stent surgeries but they keep blocking requiring more surgeries. For years I have been on Nattokinase, niacinamide and ubiquinol plus K2. Your article indicates your great lab results also using grape seed. I have not been taking the larger doses so realize this is my problem. My concern is taking K2 while on a dose of Plavix and 81 mg aspirin. Does the K2 as a coagulant create additional blockage?

Thank you Art, for your reply. My vascular surgeon does not believe in alternative medicine and is no help. He recently added Eliquis and after one week on it I ended up in hospital with bleeding. A HGB of 7.4. I also do chelation therapy but have been too sick to drive 45 miles. The last year I have had six surgeries and 3 ER visits. Now I decide. I am going on your recommended therapy and will have more lab work in 3 months.

which cholesterol you are trying to lower? LP(a) doesn't respond to anything. If your ratios are fine and inflammatory markers are normal, you don't need to lower cholesterol, unless the numbers are very high. Regular sun exposure will lower cholesterol.