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Hello, my niece developed Aplastic Anemia and received a bone marrow transplant from her father almost a year later she is developing GVHD (Graft-versus-host disease). Is there anything we can do to help?
Aplastic Anemia Remedies
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Michelle C.,
Because of the serious nature of this disease whatever you decide to do, you should include your doctor in any decisions you make regarding your niece! Here is something to discuss with her doctor. On that note, the main active constituent from different colored teas is considered to be Epigallocatechin gallate (EGCG). EGCG and in the following study, EGCG has shown benefit in GVHD models and according to the study linked to below, quercetin is helpful at increasing the uptake of EGCG while quercetin alone has no effect on GVHD, but if the quercetin allows a lower dose of the EGCG to be effective that would be helpful as there is some data that suggests that some people may have liver issues from high dose EGCG. In any case it seems worth mentioning to her doctor for review, since EGCG is a very common supplement that thousands of people use regularly with a fairly good safety profile. It also has potent antioxidant effects which would be important in GVHD. EGCG also has antiinflammatory properties which again would be of importance in GVHD.
Here is a link to a study showing potential benefit of EGCG in GVHD and based on this study, her doctor may be able to determine a functional dose for your niece. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5245838/
Here is a link to typical EGCG supplements on Amazon :
https://www.amazon.com/s?k=egcg&ref=nb_sb_noss_1
Please note that the percentage of EGCG varies considerably from product to product. Although the study is a rodent model study of GVHD, EGCG has a known safety profile in humans from other studies.
Another consideration is Curcumin which is considered to be the active component of the spice Turmeric. Here is a link to a study that suggests it may be beneficial also: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3688629/
Here is a link to typical curcumin supplements on Amazon : https://www.amazon.com/s?k=curcumin&ref=nb_sb_noss_1
One drawback to curcumin is its relatively low bioavailability, but as you review that Amazon page you will notice that there are many different formulations that offer better absorption.
Good luck to you and your niece and please keep us updated! Art
