Last Modified on Jun 18, 2014
What Is Excitotoxicity?
The pathological process by which nerve cells are damage and killed, excitotoxicity results from overstimulation. Elevated glutamate is the main culprit involved in excitotoxicity, as it is an excitatory neurotransmitter that activates the electrical signaling in nerve cells. As glutamate levels increase too rapidly, the nerve cell essentially becomes âjammedâ and is stuck in the open position. This open position allows calcium to flow into the cell without regulation, causing damage to the DNA structure of the cell and resulting in several other damaging reactions.
The main component associated with excitotoxicity is damaged nerve cells; however, this damage is typically responsible for a variety of other conditions. Several common conditions can be linked to excitotoxicity including stroke, traumatic brain injury, multiple sclerosis, amyotrophic lateral sclerosis, Alzheimer's disease and spinal injuries. The damage to nerve cells generally results in neurological symptoms that vary based on which cells are damaged and to what extent the cells are damaged.
Glutamate production is a natural function within the body; however, this increased production is what causes health concerns. Common causes of this uncontrolled phenomenon include brain and spinal injury and the intake of toxic foods.
Natural Excitotoxicity Remedies
Several natural remedies are available that facilitate the normal production of glutamate and inhibit over stimulation. Magnesium, omega-3 fatty acids and selenium assist the normal bodily functions and maintain effective levels of glutamate receptors. Likewise, red clover, zinc, milk thistle, curcumin, taurine, vitamins B1 and B6, vitamin C and vitamin E eliminate toxins in the body and support overall health, also supporting the appropriate production of glutamates. Avoiding aspartame and MSG is also important for maintaining appropriate levels of glutamate and avoiding excitotoxicity.
The controversy about Aspartic Acid (as when added to vitamin C) has caught my attention, specially with its effect as an excitotoxin. However, when I went on Wikipedia, here is what is said about it :
40% of aspartame by mass is broken down into aspartic acid (aspartate), an amino acid. At high concentrations, aspartate can act as an excitotoxin, inflicting damage on brain and nerve cells.
Humans and other primates are not as susceptible to excitotoxins as rodents; therefore, it is problematic to make conclusions about human safety from high-dose excitoxin response in rodent studies. Increases in blood plasma levels of aspartic acid after ingestion of aspartame are insufficient to cause concern for human subjects researchers."
This is found in the post on Aspartame Controversy
What do you think of this post ? I personally will not touch diet soda -or any soda for that matter; but I work in a rehab nursing center where patients and nurses drink lots of diet soda, this issue does concern me. Since I am not a chemist, it is very difficult to untangle all the interests attached to scientific findings...
A must watch video on Excitotoxins. The truth behind what we are eating. A must watch. It is a long video goes for about an hour but well worth watching if you want answers about your health.
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I have mentioned before the dangers of Excitotoxins. They are MSG and Aspartame. They damage our brains and cause cancer amongst other things. Everyone needs to research Excitotoxins. They are in ALL processed foods including Health foods. A great book to read is by Dr. Russell Blaylock, Excitotoxins, the Taste that Kills".
It is the reason kids are getting autism, and ADHD, learning difficulties, and why people are getting alzimers at an alarming rate. It is why people are getting so fat and can't lose the weight. We need to protect our families.
Here is an article of what we can take to block these so called Excitotoxins.
"How to Help Protect Your Brain From Excitotoxins:Magnesium has been discovered to help impede glutamates from overloading glutamate receptors. People with low magnesium content are the most prone to acute excitotoxicity that can cause a sudden severe digestive distress, headache, or even heart attack. Magnesium is vital to 300 biochemical functions within the body. So it is important for overall health in addition to blocking glutamate sensors or channels from excitotoxin overload. Magnesium content is high in green, leafy vegetables. It is also available in whole grains and many beans and nuts.
Omega 3 fatty acids also block excitotoxins while repairing cellular damage. Fish oils seem to be the best source of Omega 3 for this specific purpose, according to Dr. Russel Blaylock, author of Excitotoxins: The Taste That Kills, and Health and Nutrition Secrets That Can Save Your Life.
Selenium is another protector of glutamate receptors from excitotoxin invasion. It is available as a supplement. Small doses are recommended. Brazil nuts are considered a high source of selenium. Two or three Brazil nuts a day is considered sufficient for optimum selenium intake.
Red Clover was recommended by Barbara L. Minton in her September 22, 2008 Natural News article Red Clover Blocks Neurological Damage From MSG. It is basically an herb that is inexpensive and available as leaves for tea, in tinctures, liquid extracts, and capsules. According to Barbara Minton's article, lab tests demonstrated a significant decline in brain cell neuron damage when red clover's essential protective ingredient was added.
Zinc also helps obstruct the glutamate receptor channels from excessive excitotoxin absorption. Many in our society today are zinc deficient. A zinc taste test can be done to determine if one has sufficient zinc stored in his or her body. A solution of zinc sulfate is tasted for the test. If an immediate bad taste ensues, that usually indicates a sufficient zinc level in the body.
To enhance and ensure detoxification, Dr. Blaylock recommends milk thistle to help the liver eliminate all toxins. Curcumin is the essential ingredient of turmeric. It enhances bile flow as well as DNA repair enzymes. He also recommends taurine, an amino acid that contains sulfur to aid the liver, as well as vitamins B1 and B6 and vitamins C and E.
Vitamins C & E: The most important antioxidants are alpha-tocopherol or vitamin E, and ascorbic acid, also known as vitamin C. The brain normally contains one of the highest concentrations of vitamin C in the body. The advantages of these antioxidants are that they can easily enter the blood brain barrier and reach the brain cells where they are needed most. The brain is very dependent on vitamin E & C for its protection.
Read the whole article at the link: http://www.rejuvinstitute.com/excitotoxins-chemicals-destroy-health
Replied by Judy
excitotoxins and hydrolyzed plant protein
I am looking for a list of items that have these in their ingredients. I tried to do a search on the net for these items but could not find one. I found a lot of - ain't it awful articles but no list. If anyone knows where I should look it is appreciated.
Replied by Isabelle
Garden Grove, Ca Usa
Replied by Joyce
Replied by Tom
Excitotoxins: In regards to toxicity of glutamate/glutamine/gaba, how would you balance it?
I am presently on amantadine which works on glutamate receptor NMDA. But, recent books called Exitotoxins by MD Blaylock was excellent. I am taking presently to balance it with NAC and taurin. It helps. What other useful product would be good for me.
Doctor made my diagnosis as Parkinsonism, but considering everything my allergies I came to conclusion that many patients would benefit for testing of Excitotoxins since they affect whole immune system in PD and alzheimer. MSG is very bad and artificial sweeteners as well.
I would like your input, thx Maggie
Replied by Alan H