Table of Contents
- QUESTIONS & ANSWERS
- Anxiety, Panic Attacks, Intestinal Cysts
- Diluting Methylene Blue
- Fungal Infections
- General Feedback
- Mantle Cell Lymphoma
- Methylene Blue in a Nebulizer
- Multiple Cures
- Parkinson's Disease
- Swine Flu
- Using Methylene Blue
- Where to Buy
- Where to Buy: Canada
"Methylene blue is a heterocyclic aromatic chemical compound with molecular formula: C16H18N3SCl. It has many uses in a range of different fields, such as biology and chemistry. At room temperature it appears as a solid, odorless, dark green powder, that yields a blue solution when dissolved in water. The hydrated form has 3 molecules of water per molecule of MB. Methylene blue should not be confused with methyl blue, another histology stain, new methylene blue, nor with the methyl violets often used as pH indicators."
"Methylene blue was identified by Paul Ehrlich about 1891 as a successful treatment for malaria. It disappeared as an anti-malarial during the Pacific War in the tropics, since American and Allied soldiers disliked its two prominent, but reversible side effects: turning the urine green, and the sclera (the whites of the eyes) blue. Interest in its use as an anti-malarial has recently been revived, especially due to its low price. Several clinical trials are in progress, trying to find a suitable drug combination. Initial attempts to combine methylene blue with chloroquine were disappointing; however, more recent attempts have appeared more promising."
Our readers offer information and opinions on Earth Clinic, not as a substitute for professional medical prevention, diagnosis, or treatment. Please consult with your physician, pharmacist, or health care provider before taking any home remedies or supplements or following any treatment suggested by anyone on this site. Only your health care provider, personal physician, or pharmacist can provide you with advice on what is safe and effective for your unique needs or diagnose your particular medical history.
Anxiety, Panic Attacks, Intestinal Cysts
[YEA] 05/18/2013: Bennie from San Diego, California: "UPDATE; Four months of Methylene Blue.
It has no effect on chronic fatigue - doesn't give me any energy; also doesn't keep me up at night if I take it right before bed.
There are two areas where it seems to have worked magic: Cysts and Anxiety; as well as other benefits for insomnia and problem solving.
It did clear up my long term liver/kidney/diaphram/intestinal cysts, and for that, I am very grateful. I stopped taking it for about a week, and the pain radiating from what used to be the most painful cyst began to return, so I am sure this is what fixed them, although I have no idea why it came back and whether to continue taking MB indefinitely.
Anxiety: There's something about MB that fixes my generalized anxiety. It's fairly miraculous in that regard. I did not take it for anxiety, but I notice an improvement (almost total resolution) when I take it. As a result, don't need xanax. Again not sure whether it is safe to take indefinitely for anxiety.
Along with the reduced anxiety, it helps me to focus more on problem solving. Not a complete resolution but a definite improvement. I have chronic fatigue related brain fog, and it definitely gives a boost in that department so I can see why it is being used successfully in Alzheimer's patients.
I think I am sleeping better -- deeper sleep, not getting up so much in the middle of the night, because of the MB, which is huge because I've lived through 25 years of insomnia. Used to take RX sleeping pills of various kinds (4-5 days per week) but not taking them anymore.
When I first started the MB in Feb 2013, I experienced significant tingling in my head (felt like brain buzzing). I was taking several milligrams of melatonin per night, and drinking coffee during the day. Both of those were a problem while taking MB but now, after a few months, I am able to drink a regular cup of coffee now and then with no adverse reactions. I also take a much lower dose (1. 5 mg) melatonin with no side effects. For some reason, tea creates no problems.
MB had no effect on yeast/candida, herpes related virus, or fungal infections.
Other than occassional "brain buzzing", I think MB may have a negative effect on vision (blurrier, esp at higher doses). It MAY have a positive effect on acne but I've been taking a skin/nail/hair formula as well and think it is because of that that my acne has improved.
I am taking 3-5 drops of 0.1% per day.
Perhaps E.C cross post this to Anxiety/panic attacks; and intestinal cysts.
EC: Bennie's latest update has been cross posted from her thread in the Q&A section on the Methylene Blue page here: http://earthclinic.com/Remedies/methylene-blue_questions.html#Question_4567.
05/18/2013: Joy from Battleground, Wash replies: "So glad this is helping relieve some of your suffering. Curious about what intestinal cysts are. Did you get a medical picture of them? Love, JOY"
[WARNING!] 01/20/2012: Pat from Salem, Oregon: "After reading your website, I was excited to try out the methylene blue for my yeast and "brain fog". I followed instructions, taking it with powder vit c and baking soda. I took it only one time because in researching a bit more, I saw where taking Methylene blue with anti depressants can cause serious problems with the serotonin in the brain.
"Although the exact mechanism of this drug interaction is unknown, methylene blue inhibits the action of monoamine oxidase Aan enzyme responsible for breaking down serotonin in the brain. It is believed that when methylene blue is given to patients taking serotonergic psychiatric medications, high levels of serotonin can build up in the brain, causing toxicity. This is referred to as Serotonin Syndrome. " (food and drug administration webpage)
I have been on effexor for 10 years, and although I plan to go off this slowly in the summer, it looks like I will not be able to use the methylene blue as planned.
Was this on your website and I missed it? If not, you might want to add this information. I'm glad I caught it, but very disappointed I cannot benefit from taking the methylene blue. Any other suggestions?
Thank you, Pat"Replies
01/22/2012: Randy from Myrtle Beach, Sc replies: "hi Pat, Very good point you made. I know I had mentioned this in one of my previous posts. While we are on this topic... Someone also has to be careful taking Resveratrol and/or Curcumin along with any antidepressant because Resv and Curcumin also have some MAOI properties. Just a heads up."
08/29/2012: Wat from Digby, Nova Scotia replies: "more likely mis-information and half truths from FDA and Big Pharma research studies... In any event once your clean of their poisons you should have no further excuses NO! So use it then."
Diluting Methylene Blue
07/06/2011: Meera from Toronto, On, Canada: "Could someone please provide a single, lucid description of how to dilute and consume Methylene Blue? The concentration of the stuff sold at pet stores is "1, 943mg per 100ml. " How should this standard, bought solution be diluted, according to metric and Imperial systems of measurement? Measurements using cubic centimetres and the like are not much good to those of us without chemistry labs. ) Thanks."Replies
08/10/2011: David from Vicksburg, Ms, Usa replies: "1 cubic centimeter = 1 mL
1 mL = 1 g
The above are temperature dependent but work well for normal laboratory or home use. The concentration of your stock solution is 19,430 mg/L. MB solubility is approx. 1 g per 25 mL of water, 65 mL of alcohol.
At maximum solubility the concentration is 40,000 mg/L so your stock solution is a little less than 50% by volume.
Dilutions can be calculated by ratio and proportion using this formula
where M1 is the mass or concentration of stock solution. M2 is the mass or concentration of target solution. V1 is the volume of stock solution required to make target solution.
V2 is the volume you want of the target solution. for example to make 100 mL of a 0. 1% solution
50*V1 = 0.1* 100 so
V1 = 10/50
V1 = 0. 2 mL or 0. 2 grams of the stock solution
I hope this help you understand how dilutions work. I do not know what concentrations you should injest. My example is just to show you how do make the dilutions."
11/28/2012: Flora from Calgary, Alberta, Canada replies: "hi Meera ; you can purchase MB at Script pharmacy in Calgary Alberta. I am sure you have compounding pharmacys in TO. Script made mine to the concentrarion I asked for! This should make it easier for you. Hope that helps. Flora"
05/07/2011: Randa from Ontario, Canada: "I have purchased methylene blue from a pet store, it says the concentration is 1,943mg per 100ml... What concentration would that equal to?"
04/17/2011: V Kiong from Kuala Lumpur/kg Cham, Ft/kg Cham, Malaysia/cambodi: "I bought a bottle of Interpet Methylene Blue No. 10. However, nowhere was it stated the concentration. I ask the importer but they do not know. I have tried to call the company but so far have not been successful. Does anyone out there know its concentration? Thank you.
V Qiong, Kampong Cham, Cambodia"Replies
04/18/2011: Randy from Jersey City, Nj, Usa replies: "be careful with this stuff. the way I've used it is to take one drop into a gallon of water, then dilute a bit further every time I take it by filling a cup or water bottle with 1/2 or 2/3 of the MB mixture and the rest with just water. don't forget to take with 1000mg vit c"
11/30/2010: Terri from Fort Myers, Florida: "I purchased a 2.303% methylene blue solution from local pet store. Instead of going through dilutions, can anyone tell me in simpler terms such as 1-2 drops in 16 oz. Water?"Replies
11/30/2010: Self from Ny replies: "You could add one drop of 2.3% MB to 18 cups of water (which also equals one gallon and one pint of water) and take one cup of this twice a day. You do not want to take too much MB or it can make your mind too active. Don't forget to take 2,000 milligrams (or 2 grams) of vitamin C (sodium ascorbate) a day too."
11/30/2010: Tom from Regina, Sk replies: "Terri:
I'm assuming you meant to ask "... To end up at 0.1% concentration"?
If so, then this means that you need 22 times as much water volume to dilute as the amount you're wanting to dilute, since. 1% IS 1/23 of 2.3%. The total of 1 part solution and 22 parts water will equal the total watered-down volume 23 parts. To make the math a lot easier, one can just dilute 20:1, ie 20 parts water to 1 part solution and be very close. Measurement quantities:
20 metric drops per ml
5 ml per teaspoon (Tsp)
3 Tsp per tablespoon (Tbsp)
2 tablespoons per ounce
Thus 600 drops, or 30 ml, or 6 teaspoons per ounce. 1 cup= 8 oz= 4800 drops= 240 ml= 48 Tsp= 16 Tbsp
So there it is. Using the 20 ratio for dilution, to get 1 cup watered down solution, just dilute 240/20= 12 ml of 2. 3% (just use a kitchen measuring spoon of 1 Tsp= 5ml) INTO the 1 cup of water."
12/21/2010: Claudia from Calgary, Alberta , Canada replies: "I got my methylene blue from the pharmacy. The pharmacist had absolutely no idea how to provide a 0.1% solution, so what I have now is 50mg/ml. Does anyone have any idea how to convert this? TIA."
02/08/2011: Amazinggrace from Yucca Valley, Ca replies: "I don't have metric measuring instruments, so to get a 1:22 ratio, I used one Tablespoon of methylene blue and 22 Tablespoons of water. 22 Tablespoons equals 1 and a quarter cups plus 2 Tablespoons. (Derived from 16 T. = 1 Cup)"
01/09/2012: Randy from Myrtle Beach, Sc replies: "Does anyone know how many drops of the diluted. 1% of the MB one would have to take for it to have an MAOI effect?
Also, would anyone know what the conversion would equate to of X amount of drops of. 1% solution of MB to X amount of mcg's or mg's of MB?"
01/10/2012: Randy from Myrtle Beach, Sc replies: "I also should have added to my post about that I do know that MB can have MAOI properties but I do not know if it has those properties at the suggested drops of. 1% solution of anywhere between 3-8 drops on this site that is suggested. I think it would be wise if anyone could determine how many drops it would take at the. 1% solution to have MAOI effects.
Maybe Ted could weigh in on this. Reason being, if someone were to ridiculously experiment with many more drops and get in the range of it acting as an MAOI, then it is dangerous to do so if in particular that you are taking it along with an SSRI antidepressant.
To be on the safe side might as well include if taken with an NRI as well. Do your own web research to confirm this. I do take MB for added energy but I also take more drops than 8 with no adverse effects. I'm not recommending anyone else take more than 8. Everyone is different... Plus I also am not on any antidepressant. Just a word of caution here if anyone is unaware of the MAOI effects of MB and not to mix with AD's if in fact you are getting in range with the drops to have it act as an MAOI."
10/25/2012: David from Nerja, Malaga/spain replies: "I have 100mg MB powder. Do anyone know how to much 0.1 solution this will make? Do I just mix 1ml with 1l water?"
10/10/2009: Merryanne from Orange City, Florida, USA: "Hello, this is Merryanne in Central Florida,,,I order of Methylene Blue has arrived,,,I ordered a 32oz bottle,,will I have a 32oz bottle with a little bit of powder in it,,,I read the directions and your to fill with distilled water to the top. I called to find out what percentage the mix would be,,but the girl does not know..I contacted the manufacture and left a message to give me that information. I ordered form a company in OH that thinks they are the solution ...Does anyone have any clue about this,,what the mix solution might be???merryanne"Replies
10/13/2009: Merryanne from Orange City, Florida, USA replies: "This is Merryanne,,,I received a call back from the manufactor of the 32oz contanier with a little methylene blue powder in it--he said that after filling with water you have a 2.3% solution. That did answer my question,,but now I have several more (since I did not take the call my message taker did) like how long is that going to be good for, I will have to dilut some of it to 0.1%. So I am going to call him back on Wednesday (when I am off work) and find out how much of his powder it takes to make a 0.1% solution. Then I want be wasting the powder,,because 32oz of 2.3% diluted down to 0.1% is a lots, and lots of solution. And I don't think the shelf life is long enough,,I will ask if it can be frozen. I will let you know what they say.
[QUESTION] 05/02/2009: Ab from Toronto, Ontario: "Can anyone tell me how to make a 0.1% solution from 2.303% (aquatic) solution methylene blue from a pet store?
08/10/2009: Connie from Manitowoc, Wisconsin replies: "To quote Ted: "When you do buy methylene blue, the concentration may sometimes be sold as 1%, in which case you may need to dilute this to 0.1% concentration. So if a 100 cc of 1% methylene blue is bought from a local aquarium shops, I may have to add 900 cc of water (which totals) 1000 cc or 1 liter at 0.1% concentration." - end of quotation
So if you had a 2.303% solution you would use just under 50cc of 2.303% methylene blue and 900cc of water. Does that sound right?"
12/03/2009: Sarah from Los Angeles, Ca replies: "wow- this gets sooo confusing. OK- so I have the littel bottle of Meth Blue from science lab website... I am trying to convert the measurements here: If I have 100 cc, that equals 3 and 1/2 ozs., and then to mix the 1:9 ratio, I mix that 3 and 1/2 ozs. with a liter (900 ccs of water?) thanks... am trying not to poison myself...."
10/13/2010: Lis from Ny, Ny, Usa replies: "When diluting this, set up protective material underneath. MB stains! I rubbed vitamin C and water paste in the measuring glass and spills on the sink and counter and on my hands to get it out. If only I had a chemistry background to do a more pro job diluting it ;p"
03/05/2013: Luckyguys from Brighton, United Kindom: "Several posts insist that the correct dose of MTB is 60mcg three times a day. Surely it MUST be 60 mg because they seems to use Uralene Blue tablets at the beginning of the trial and these are 60mg.
I don't understand the reasoning behind the 60mcg beliefs"
01/16/2009: Joyce from Joellton, Tn: "For everyone with fungal infection:
Deirdre, you might want to get Ted's opinion and post it. I just read Ted's methylene blue for Parkinson's disease. What really caught my attention was that methylene blue is sold in aquarium shops to kill fungus in the fish. DING!!!!
The question pops up: Is Parkinson's disease a fungal infection of the brain?
Something else that pop's up is the Italian method of treating cancer patients with baking soda to kill the fungi and the cancer goes away on its own!!!
It would seem that if methylene blue kills fungi in fish, it should also kill fungal infections in most, if not all living creatures, so maybe this should be posted on cancer pages. As I recall the interview with the Italian doctor shown on Dr. Mercola's site, the Italians believe that all cancers are preceded by a fungus. If this is true and methylene blue kills fungal infections, doesn't it follow that maybe all cancer treatment should begin with a substance that wipes out fungi?
Of course common sense tells you to also change the eating habits that caused you to have the fungus problem"Replies
[YEA] 01/20/2009: Ted from Bangkok, Thailand replies: "I used methylene blue to kill fungus infections anyway. A fungus damages sensitive organs, in particular, the brain, thymus, adrenal, pancreas, spleen, thyroid, are some of the things I noticed. A fungus is killed by sodium bicarbonate because of its alkalinity, but more effectively so with potassium, magnesium, for example because it kills alkalinity intracellularly as opposed to extracellularly. This is known for ages and the doctor you have mentioned to me was Dr. Simoncini. However, I have went further to look at fungicides besides methylene blue which are more effective, such as azoxystrobin, afloxystrobin and related strobilurins. Those are much more effective at much lower dose. The depth in which baking soda is limited to extracellular fluids, but are limited in bone cancer and bone marrow where baking soda is neutralized before reaching these areas, hence the necessity to use antifungals methylene blue being one of that. The issue is not well explained at other websites WHY fungus causes cancer, but the cause is not fungus in itself, it's the toxins generated by the fungus, such as mycotoxin and aflaxtoxins are the well known cancer causing substance from fungus and perhaps mycobacterium. Hence, the toxicity of mycotoxins and aflatoxins may be reduced with the BHT, but to eliminate them effectively, a potassium should be added along with baking soda. The only issue is baking soda is not so effective because of its limited alkaline buffering capacity if we compared against the carbicarb plus potassium which goes much more deeper. The Carbicarb is a sodium carbonate plus potassium citrate (e.g. technical name is tripotassium citrate). In fact two major sodium that are more effective is the sodium citrate (e.g. trisodium citrate) and potassium citrate (e.g. tripotassium citrate) and sodium carbonate with equal mix of sodium bicarbonate (commonly called carbicarb). However the current carbicarb remedy in practice isn't that perfect and may cause some kidney pain because of sodium potassium imbalance, and hence, a potassium must be added to the carbicarb remedy to resolve this problem and larger dose can be taken.
It must be noted still that I have noted two kinds of cancer, the fast cancer and the slow cancer. The faster cancer are the metastatic cancer, which are viral in character while the slower cancer are the fungal type cancer which tends to cause bone pain and leads to osteoporosis. Still I haven't even cover how you can eliminate the tumors and this is dealt most effectively with a bloodroot tincture.
I hope this explains just a small portion of my approach to dealing with cancer.
06/06/2010: Mary from Regina, Saschewan replies: "Dear Ted:
Thank you so much for this information. Especially for the clarity on which remedy reaches intracellularly and which on can only help extracellularly. I have a friend with bone cancer right now and would really like to assist him.
I need clarity on the exact chemicals i should suggest. You seem to conclude that the optimal one is carbicarb plus potassium citrate. Is this accurate? I was not sure if I was getting what you meant. Thank you!!"
08/19/2012: Booradley from Neverland, Texas, USA replies: "Are there any over the counter supplements or medications one shouldn't take if they are also taking methylene blue? (I would be taking 8 drops twice daily of 0. 1% methylene blue solution in water.)
Supplements I take:
- ascorbic acid powder (18 grams daily)
- calcium citrate
- magnesium threonate
- b complex
- b12 (methylcobalamin)
Conditions I hope to see improvement with are Alzheimer's, arterial blockage, and severe osteoporosis. I am following Ted's suggested protocol for stopping progression of Alzheimer's. The other supplements are for osteoporosis and arterial blockage. I also follow raw foods diet rich with anti-inflammatory foods. Thanks."
08/20/2012: Mmsg from Somewhere, Europe replies: "Booradley, here on EC there is lots of talk about Coconut oil for Alzheimers. (Not to add more supplements to your long list, but this is a food! )"
08/20/2012: Gavin from Manganui, Northland, New Zealand replies: "Have you read the latest on altzhimers, that it might be type 3 diabetes, with regards to the brain being unable to metabolise insulin.. which would certainly back up coconut oil as it gives the brain energy via ketones and not sugar."
11/08/2012: Farm Girl from Tempe, Az, Usa: "Has anyone using Methylene blue (and getting a positive response) been tested for Brucella or Lyme's Disease?
Both diseases are chronic infections that are notably hard to cure, requiring 6 weeks to up to 2 years of strong antibiotics, because these pathogens replicate in cells where the antibiotics can't reach, ensuring fresh crops of pathogens about every two weeks. Also, patients may have initially bad symptoms when first taking the antibiotics because as the pathogen dies, it releases toxins.
When taking MB, or any other medicine, for infection, PLEASE take it long enough and at a high enough dose to completely eradicate the pathogen. Otherwise you may be simply creating another Superbug that neither MB nor antibiotics can cure."
01/21/2012: Robyn from Melbourne, Australia: "Methylene Blue: I just read it can help with clearing ca. Is this so? I have been using a couple of drops in a 600 ml of water. Is it effective without the vit c?"
EC: Hi Robyn,
By ca, do you mean cancer? Medical abbreviation list for Ca also includes: carcinoma, cardiac arrest, chronologic age, and cytosine arabinoside.
01/23/2012: Robyn from Melbourne, Australia replies: "sorry I mean calcium. Does it help clear excess calcium lying around in tissues, arteries, I assume causing at least part of this extreme pain ALL the time."
01/24/2012: Timh from Louisville, Ky, Usa replies: "Robyn, the amino acid Taurine helps the body use minerals, and Vit-K helps the body use Calcium in particular."
01/24/2012: Robyn from Melbourne, Australia replies: "Yes, use both taurine and K2 I've read calcium in the tissues causes pain, ca blocking the arteries causes stiffness but maybe thats not the reason for UNBELIEVABLE pain. Reading all the fibro case studies does nothing to ease my mind.
Please if anyone has got better from fibro tell us about it. If anyone has got better from chemical sensitivity tell us about it. I've now got myself too sick to get away from pollution and other chemicals. And very lonely when you can't go near people. EC it would be good if there was a way to contact people who have posted up their case study. I got some more helpers for my liver; NAC, grapefruit seed extract, milk thistle - had a huge reaction, unbelievable pain, couldn't move for a week. Stopped them and the pain is now down to I can't stand it. So if I'm taking taurine and K2 I don't know if I'm making myself worse or not.... overactive immune system?? or a crapped out liver that reacts to what's sposed to help it."
01/25/2012: Kathy from Cumberland Gap, Tn replies: "I was treated for fibromyalgia for about six years. I would pray that I would not wake up if I had to live like this the rest of my life. To make a long story short I had mercury poisoning. Had to have 14 teeth pulled due to caps and so many fillings. Went back to check book and pain began shortly after having caps put on teeth. I felt better than I had in years even though I had 14 teeth pulled the previous day. No pain since Sept 14, 2008. Hopes this helps you."
01/25/2012: Timh from Louisville, Ky, Usa replies: "Robyn, have you tried the "Chemical Injury Information Network", Member supported group of Multiple Chemical Sensitivity? I have suffered many yrs disability with environmental illness, but I somehow do no suffer the severity of symptoms of this group or fibro, so there is a big curve of individuality.
Have you done parasite cleansing? There are both chemical and natural methods but I can't imagine you haven't addressed this already but I suggest it because these buggers cannot be "detoxified" w/ the list of naturals you provided. You may have very little in the way of elimination. Have you done gallbladder and colon cleanses? Don't rule out some type of viral Hepatitis even though you haven't had that diagnosis (like myself). I have responded favorably to the St John'sWort, Lysine, Colloidal Silver only in combination. BHT seems to be helping remarkably but it's only been about 5 days now so I cannot conclude. Detox Foot Pads are quite effective for all kinds of toxins, have you tried them? You can purchase them at wholesale prices on Ebay. Hot Baths with minerals must bring you some relief. I use Baking Soda, Epsom Salt, and micronised agriculture grade multiminerals ---1/4 cup of each and ALWAYS come out the better. And to treat fungal issues add some Borax or Povidone Iodine.
Please update as you appear to need some help from these debilitating "invisible" disease conditions."
12/14/2011: Leftsidedrivetony from San Diego, California, Usa: "I just bought some methylene blue, it is for staining glass for microbiology, the product is called methylene blue aqueous solution, is that the right one for human consumption? And it is at 1% please get back to me as soon as you can. Thank you
07/28/2011: Mebeingme from Sarasota, Fl, Usa: "Does anyone know about treatment for this?? My sister has been taking IV methylene blue. She's had terrible reaction, but has been told this treatment or death
07/24/2009: Alain from Ottawa, Canada: "One of Ted's last post, I noticed methylene blue. Because it has been mentioned a few times already, I just thought it would be a good idea to add it in your list of remedies.
Keep up the good work!
EC: Thank you for the great suggestion, Alain - done!