Ubiquinol Benefits, Uses, and Side Effects

on Jul 27, 2023| Modified on Feb 02, 2024

Editor's Note: A special thanks to Art Solbrig, whose recent articles and posts on Earth Clinic have shed valuable light on the wide array of health benefits ubiquinol offers, especially at higher dosages.

In the arena of health supplements, ubiquinol is gaining recognition for its impressive antioxidant properties and its essential role in producing cellular energy. Recent studies focusing on high-dose ubiquinol, particularly at doses exceeding 1000 mg daily, have demonstrated significant benefits in cardiovascular health, neuroprotective effects, and treatment of mitochondrial disorders. This has led to ubiquinol's growing popularity among health enthusiasts, athletes, and researchers, often regarded as a superior alternative to its closely related compound, Coenzyme Q10 (CoQ10).

This article will delve into the multifaceted benefits of ubiquinol. It will shed light on its promising therapeutic potential, especially at high doses, in supporting heart function, slowing down neurodegenerative diseases, improving mitochondrial function, and why it's increasingly becoming vital in a balanced, health-conscious lifestyle.

What is Ubiquinol?

Ubiquinol is the active, reduced form of CoQ10, a compound found naturally in the body, particularly in the heart, liver, kidney, and pancreas. Ubiquinol is essential in cellular energy production and offers robust antioxidant protection, making it a vital part of a healthy lifestyle.

What is Ubiquinol Made From?

Ubiquinol supplements are derived from a carefully controlled fermentation process involving specific yeast or bacteria strains. These microorganisms help synthesize CoQ10, which is then reduced to its active form, ubiquinol.

Some supplements may contain ubiquinol extracted from natural sources like soybeans or tobacco leaves, though microbial fermentation remains the most common method.

The produced ubiquinol is typically blended with other ingredients, such as oils (e.g., sunflower or olive oil), to enhance its absorption in the body. Some formulations may include additional antioxidants or vitamins to support ubiquinol's health benefits further.

It's important to note that the quality of ubiquinol supplements can vary widely between manufacturers. Factors such as the purity of the initial CoQ10, the reduction method, and the choice of additional ingredients can influence the effectiveness of the final product.

Ubiquinol's Health Benefits

Powerful Antioxidant Protection

Ubiquinol serves as one of the body's most potent antioxidants. It neutralizes harmful free radicals, protecting cells from oxidative stress. This process is critical in maintaining overall health and slowing the aging process.

Enhanced Energy Production

As a crucial part of the electron transport chain, ubiquinol aids in the production of adenosine triphosphate (ATP), the body's primary energy source. Regular supplementation can boost energy levels and enhance physical performance.

Supports Heart Health

Clinical research has indicated ubiquinol supports heart health by improving blood lipid profiles and maintaining optimal blood pressure. It's no wonder it's becoming a key player in cardiac health maintenance.

Improved Neurological Health

Several studies suggest that ubiquinol can benefit neurological health. Its antioxidant properties may support brain function and cognitive health, making it a promising supplement for conditions like Alzheimer's and Parkinson's disease.

Enhances Immune System Function

Ubiquinol can also benefit the immune system. Protecting immune cells from oxidative damage bolsters the body's defense mechanism, ensuring robust resistance against illnesses.

Supports Healthy Vision and Hearing

Ubiquinol has been found to support eye and ear health. Studies have suggested that the antioxidant properties of ubiquinol may help slow the progression of age-related macular degeneration and prevent hearing loss.

Beneficial for Fertility

Emerging research suggests that ubiquinol may improve both male and female fertility. For men, it may enhance sperm motility, while in women, it may improve egg health.

Helps to Maintain Healthy Blood Sugar Levels

Research has shown ubiquinol supplementation may help maintain healthy blood sugar levels by improving insulin sensitivity.

Skin Health and Anti-Aging

As a powerful antioxidant, ubiquinol may support skin health by neutralizing harmful free radicals contributing to skin aging. Regular supplementation can aid in reducing wrinkles, improving skin texture, and boosting overall skin health.

Supports Lung Health

Preliminary research suggests ubiquinol may support lung health, potentially benefitting conditions like chronic obstructive pulmonary disease (COPD) by reducing oxidative stress in lung tissue.

Lowers High Blood Pressure

Ubiquinol's unique properties, as noted below, make it beneficial for those seeking to maintain a healthy blood pressure range:

1. Improved Heart Function

Ubiquinol is crucial for the efficient functioning of the heart. Supporting cellular energy production helps the heart maintain its vigorous rhythm, which is vital for maintaining healthy blood pressure levels.

2. Antioxidant Protection

Oxidative stress is linked to high blood pressure, and ubiquinol's potent antioxidant capabilities can help neutralize this oxidative stress. This aids in the preservation of the blood vessels' integrity and function, promoting healthy blood flow and, consequently, blood pressure.

3. Supports Optimal Cholesterol Levels

Emerging research suggests that ubiquinol can help maintain healthy cholesterol levels by reducing LDL ("bad") cholesterol and increasing HDL ("good") cholesterol. Balanced cholesterol levels are linked to healthier blood pressure.

4. Enhanced Nitric Oxide Levels

Ubiquinol can stimulate nitric oxide production, a molecule that helps blood vessels relax and dilate. This dilation helps reduce the pressure in the vessels, thereby aiding in blood pressure management.

The Difference Between CoQ10 and Ubiquinol

CoQ10 is available in two forms: ubiquinone (oxidized) and ubiquinol (reduced). Both forms are essential for bodily functions, yet they aren't equally effective when consumed as dietary supplements.

Ubiquinol holds an edge over ubiquinone for several reasons. First, it's more bioavailable, meaning your body can absorb and use it more efficiently. Studies show that ubiquinol is absorbed up to eight times more readily than ubiquinone, maximizing its benefits.

Secondly, ubiquinol is the 'ready to use' form of CoQ10. Once absorbed, ubiquinone has to be converted into ubiquinol to function within cells. As we age, our body's ability to make this conversion decreases, making ubiquinol the superior choice for older adults.

Potential Ubiquinol Side Effects

Ubiquinol is generally considered safe and is well-tolerated by most people. However, as with any supplement, it can potentially cause some side effects, especially when taken at higher doses.

Possible side effects may include:

  • Gastrointestinal Issues: Some individuals might experience mild digestive discomfort, such as nausea, loss of appetite, or upset stomach.
  • Skin Rashes: In rare cases, some people might develop skin rashes as a reaction to ubiquinol.
  • Low Blood Pressure: Since ubiquinol can naturally lower blood pressure, people with already low blood pressure or those on blood pressure medication should monitor their levels closely when taking this supplement.
  • Insomnia: Some people have reported sleep disturbances, especially when taking high doses of ubiquinol.

Please note that the side effects of taking high doses of ubiquinol aren't commonly observed and might differ from person to person.

Ubiquinol Dosage

There isn't a one-size-fits-all answer regarding the dosage of ubiquinol. The appropriate dose depends on several factors, including age, overall health, and specific health concerns.

That being said, the commonly recommended daily dose of ubiquinol for adults is between 100 and 200 mg. However, a healthcare professional might suggest a higher dose for specific health conditions or those over 50. People taking statin medications, which can deplete the body's natural CoQ10 levels, might require a higher dose. Similarly, athletes or highly active individuals may need a higher dose due to increased metabolic demands.

High-Dose Ubiquinol Studies: Venturing Beyond 900 mg

While typical daily doses range from 100 to 300 mg, studies exploring higher dosages of ubiquinol have surfaced, revealing promising potential for various health applications:

Multiple-System Atrophy (MSA) Study

In a significant study on patients with multiple system atrophy (MSA), a rare and progressive brain disorder, researchers explored the effects of ubiquinol, a supplement known for its role in energy production. Participants were divided into two groups, with one receiving 1500 mg of ubiquinol daily and the other a placebo. After 48 weeks, the group taking ubiquinol showed a slower decline in their symptoms than those on the placebo.

The high-dose ubiquinol group also exhibited some additional improvements in their ability to move and perform daily tasks. Importantly, the high dose of ubiquinol was well-tolerated, and the study found no significant difference in side effects between the two groups.

Cardiovascular Health

Some trials have explored the impact of high-dose ubiquinol (900-1200 mg/day) on cardiovascular function, particularly among individuals with heart failure. Preliminary results show enhanced heart function and improved blood lipid profiles.  In one 2008 study on patients with advanced congestive heart failure (CHF), ubiquinone supplementation failed to improve CoQ10 levels even at dosages up to 900 mg/day. When seven patients were switched from an average of 450 mg/day of ubiquinone to an average of 580 mg/day of ubiquinol, a remarkable improvement in plasma CoQ10 levels and heart function was observed. The clinical improvement was correlated with the near doubling of the ubiquinol dosage, emphasizing its significant effect on severe heart failure patients.1

Parkinson's Disease

Besides MSA, other neurodegenerative disorders like Parkinson's Disease have been the subject of studies. High doses of ubiquinol have shown the potential to slow down disease progression.2

Mitochondrial Disorders 

Given ubiquinol's central role in cellular energy production, studies have explored high-dose supplementation for mitochondrial disorders. A daily dose exceeding 1000 mg has improved energy levels and mitochondrial function.3

Ubiquinol for Athletes: Enhancing Performance and Recovery

Ubiquinol is an important supplement in sports nutrition due to its unique health benefits that align well with the needs of athletes.

  1. Increased Energy Production: Ubiquinol plays a pivotal role in producing adenosine triphosphate (ATP), the body's primary energy currency. Increased ATP means enhanced energy levels, endurance, and overall athletic performance.

  2. Reduced Oxidative Stress: Intense physical activity increases the production of free radicals, which can cause oxidative damage. As a potent antioxidant, ubiquinol helps neutralize these free radicals, protecting the body's cells from oxidative stress and supporting quicker recovery.

  3. Improved Cardiovascular Health: The heart is a major consumer of ATP. By optimizing ATP production, ubiquinol supports heart function, which is crucial for athletes who constantly push their cardiovascular systems during training and competitions.

  4. Enhanced Muscle Recovery: Research suggests ubiquinol may help reduce inflammation and expedite muscle recovery after strenuous exercise, potentially reducing downtime between training sessions.

Recommended Dosage for Athletes

The ideal ubiquinol dosage for athletes varies based on age, training intensity, and overall health. However, many experts recommend a higher dosage for athletes than the general population due to increased metabolic demands.

Research indicates that a daily dose of 200 mg to 300 mg may be beneficial for enhancing athletic performance and promoting recovery. Some studies suggest that the dosage could be increased up to 600 mg daily, split into two or three doses for maximum benefit.

This study published in the European Journal of Nutrition recommended a daily dose of 300 mg of ubiquinol to enhance physical performance and reduce fatigue in elite athletes.

Where to Buy

Two products on Amazon with varying per capsule milligram potency:

Jarrow - 200 mg - 60 Softgels

High-Dose Ubiquinol Capsules

800 mg  - 60 Softgel


In summary, ubiquinol has emerged as a vital component for overall health and wellness, particularly effective in high-dose supplementation. Its potent antioxidant capabilities and essential function in energy creation cover a broad spectrum of benefits, making it a powerful ally in maintaining a healthy lifestyle.

Compared with ubiquinone, ubiquinol stands out for its superior absorption, ensuring that individuals get the most from each high dose. It contributes to various aspects of health, including promoting heart health, boosting athletic performance, enhancing neurological function, and supporting healthy vision, hearing, and blood pressure. Its potential role in weight management and the increased effectiveness of high doses make ubiquinol an attractive supplement for those pursuing a balanced, health-conscious lifestyle.

Do you take ubiquinol? We would love the hear your feedback!  Continue reading below for feedback from Earth Clinic contributors.

Benefits of Ubiquinol

2 User Reviews
5 star (2) 

Posted by Art (California) on 07/31/2023 2164 posts

A Few Words About Ubiquinol, A more Bioavailable Form Of CoQ10

Since Deirdre just posted this new article about Ubiquinol/CoQ10 and its many health benefits here,


I thought I would mention that I am currently using Ubiquinol at 800 mg/day. Some of you may wonder why so high of a dose, and the reason is simply because newer studies using higher dosing than what used to be the norm, are showing more benefit. As an example, this 2023 study in Multiple System Atrophy (MSA) patients used 1500 mg/day to good effect at slowing disease progression. Keeping in mind that MSA is essentially an untreatable disease with a life expectance of just 3 to 5 years after diagnosis, this is an important study illustrating the value of higher dosing of ubiquinol.


Here is a relevant quote from the study :

' High-dose ubiquinol was well-tolerated and led to a significantly smaller decline of UMSARS part 2 score compared with placebo. '

Although ubiquinol has shown benefit in relatively short term for specific health issues, I am not taking ubiquinol to try and radically improve a specific aspect of my health, but rather similarly to melatonin, to increase my chances for better health in my later years of life and to help stave off age related diseases, of which there are many such as cancer and cardiovascular disease as two big ones.

Ubiquinol, like melatonin, works to improve mitochondrial efficiency and function. Properly functioning mitochondria supply the power for the cells to operate properly and effectively. Poor functioning mitochondria are common in many disease states. The following study confirms that poorly functioning mitochondria are seen in multiple disease states :

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7255501/#:~:text=Mitochondrial damage is implicated as, insulin resistance/type 2 diabetes.

Here is a relevant study quote :

' Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. '

Here is a study illustrating the value of ubiquinol as being beneficial in cardiovascular disease while helping to improve mitochondrial function as well as highlighting that one of the most common statins in general tends to inhibit CoQ10 availability in the body. CoQ10 also acts as an antioxidant :


Here is a relevant quote from the study :

' Although the importance of CoQ10 can mostly be attributed to its function as an essential molecule for energy transduction in mitochondria, new findings support its relevant function as an antioxidant, not only in mitochondria, but also in other cell compartments and tissues in the organism as well as in plasma lipoproteins. Endogenous CoQ10 biosynthesis supplies sufficient levels of this quinone in disease-free individuals. However, CoQ10 deficiency is not only based on genetic failure, but also on chronic and age-related diseases such as CVDs. In this context, CoQ10 deficiencies have risen in CVDs, since statins, one of the most common lipid-lowering drugs used in CVD patients, diminish endogenous CoQ10 biosynthesis because its initial steps are shared with the cholesterol biosynthesis pathway. In this context, it has been shown that CoQ10 can potentially be used as a treatment to ameliorate these deficiencies. '

So for me, I am looking more in the long term use of ubiquinol for my overall health in a similar way as I look at melatonin.


Replied by Art
2164 posts

When it comes to Ubiquinol/CoQ10, dosage matters.

In the following study (2018) using 100 mg/day dosing of ubiquinol, the study showed that ubiquinol at 100 mg/day had beneficial effects toward improved diabetic parameters in people with diabetes, but had no significant impact on cholesterol and triglycerides:


Here is a relevant quote from the study :

' After 12 weeks of supplementation, glyco Hb (HbA1c) value was significantly decreased in the liquid ubiquinol group (P=0·03), and subjects in the liquid ubiquinol group had significantly lower anti-glycaemic medication effect scores (MES) compared with those in the placebo group (P=0·03). The catalase (P<0·01) and glutathione peroxidase (P=0·03) activities were increased significantly after supplementation. Plasma coenzyme Q10 was correlated with the insulin level (P=0·05), homoeostatic model assessment-insulin resistance (P=0·07), quantitative insulin sensitivity check index (P=0·03) and the anti-hyperglycaemic agents' MES (P=0·03) after supplementation. Lipid profiles did not change after supplementation; however, the subjects in the placebo group had a significantly lower level of HDL-cholesterol after 12 weeks of intervention. '

On the other hand, this meta analysis ( December 2022) of randomized controlled trials (RCTs) showed that not only did higher dose CoQ10 lower cholesterol and triglycerides, but 400 to 500 mg/day was most effective :


Here is a relevant quote from the meta analysis of RCTs : ' Conclusion: CoQ10 supplementation decreased the TC, LDL-C, and TG levels, and increased HDL-C levels in adults, and the dosage of 400 to 500 mg/day achieved the greatest effect on TC. '

So here we see that while 100 mg/day ubiquinol has no effect on cholesterol and triglycerides, a dose of 400 to 500 mg/day definitely does have a significant lowering effect.

Proper dosing matters depending on what you are trying to achieve with ubiquinol/CoQ10.


Energy, Mental Clarity

1 User Review
4 star (1) 

Posted by kildonon (lebanon, ohio) on 02/02/2024


Ubiquinol and COq10 causes severe swelling of my feet and ankles. It does, however, help my energy levels and mental clarity.

Fatigue and Brain Fog

1 User Review
5 star (1) 

Posted by jake (chicago) on 04/21/2023

Hi Art -- I told my cousin - long suffering with long covid fatigue and brain fog -6 months at least- - about the new supplements shown in studies to show positive benefits. Last week and again this week he called to tell me - he could hardly believe he was that same person, pre our conversation. He was already taking arginine and coq10 before, but he changed over to ubiquinol and doubled to twice a day as well. He also added and took ALA along with the ubiquinol, as the studies suggest- taken together boosts the effects of each taken separately. He also takes (only) 5 mg melatonin as he does not tolerate it that well.

Thanks to you and all contributors for being the community of helpful info, sharing anecdotal successes and spreading protocols that might help others as in this case of my cousin - who can't thank me enough for bringing Art's information to him.

High Blood Pressure

3 User Reviews
5 star (3) 

Posted by Tim (OR) on 08/18/2023

My blood pressure has been high for a while, as a 61 year old male I have held off the medical establishment which wanted me on their bad drugs. I needed a tooth pulled the dentist nearly didn't do it because of the blood pressure reading. This is how they force you onto their drugs. Saw the Earth Clinic alert about Ubiquinol, decided to try it. Currently using Besibest Ubiquinol CoQ10 600MG from amazon twice a day. Four days in to this protocol, the top number which had been high at as much as 190 and the second number 115; not always but too often; Suddenly I am down to 135/87. Nothing else I have done has had this impact. I have tried the standard CoQ10 supplement but had no dramatic BP decline. I am feeling fine, no obvious negative side effects, if this continues to work so well I will happily avoid the medical establishment and one of their favorite ways to get people on drugs.

Replied by jake

I used to spike like you - over 200 systolic, over 100 diastolic -I followed Art's recommendation - carditone. from the first pill I'm normal- as long as I remember to take it - sometimes only once every 2 days

Replied by Barbara

I am glad your BP is under control, but 600 mg of Ubiquinol 2x per day is extremely high! I am 64, have borderline high BP and take 100 mg per day. I am going to increase the dosage after reading this, but please consider lowering the dosage some; maybe 600 mg per day to start. I follow Dr. Mercola and he does not advocate super-high doses. It's usually best to start small and work up to a maintainable daily dosage.

High Blood Pressure
Posted by Andrea C (Wales) on 10/01/2013

RE: High Blood pressure, Coenzeyme 10 (Qc10) will lower your blood pressure better than any Drug in the World that a DR can give you. 150milligram's 3 times a day, it can be taken along side your BP Med's if you've been scared and bullied enough by DR's to take it, it will not interfere with any Med's. I have helped Gang's of people with this, and I was one of them. My BP went fatal, last week I got it checked and I've got the BP of a super fit 18 year old and I'm 54yrs young. I never took any Med's as they cause more damage. It has to be Ubiquinol (there are many forms of Cq10), and a good Omega 3 oil is excellent too. Cq10 is made naturally by the body, but lower's with age and other factors. Statins are also evil, I met load's of people in Hospital that had heart attack's caused by Statins, an everyone I know has got heart damage from these Drug's. Its a lie about High Cholesterol, we need it. Our Brain's are made of it, Beet root juice lower's it brilliantly if you really believe it should be lowered, but it's got NOTHING to do with Heart Attack's. It's just another scare mongering tactic to sell more Drug's and make even more money for the evil one's. Do you think they take their own poison? No, they go to Health spas and eat Organic food, and natural remedies. And Detox in luxury using the money they scared everyone in to parting with for drug's. Love Andrea C xxxx

Replied by Gdhealed

I gave a family member who was on blood pressure medicine Ubiquinol: a very good brand highly absorbable, with safflower oil. After taking it, one day he dropped to his knees. Taken to emergency room he was told his blood pressure was very low. I did not know his medication prior to giving him ubiquinol. I agree with everything else in the post. How many milligrams of CoQ10 can be taken with BP medicine?

Maybe because Ubiquinol is more absorbable form of CoQ10 makes a difference? Also, same product taken by a woman with heart condition aND subject to lung blood clots caused profuse sweating. Why?

I agree with this post regarding conventional med prescribed which is why I continue with vit, and supplements.


As Ubiquinol can lower your blood pressure it's good to start with a low dose and see how your body reacts as well as take your bp measurements. If it goes too low (what's considered low bp) and you take bp meds then maybe you can reduce the bp meds to keep your bp in a more ideal range. Taking both simultaneously maybe too much of a reduction in bp.

High Cholesterol

1 User Review
5 star (1) 

Posted by Dave (Fountain Inn, Sc) on 11/03/2013

Just this morning Dr. Mercola's latest newsletter (November 3, 2013) considers the superiority of the derivative of CoQ10 which is ubiquinol on LDL oxidization. He asserts that a hundred studies say ubiquinol is more bio available than CoQ10 and he is especially worried about the millions of people on statin drugs. Someone on Earth Clinic (a poster I mean) got me on Dr. Mercola and he has excellent articles and information.

In the November 3 article on ubiquinol he discusses how ubiquinol is carried by the LDL shuttle (I discussed in my first post to you how the LDL and HDL are protein shuttles to carry cholesterol within the body, and the "shuttles" were not bad at all but in fact are essential to health; and that the only thing bad is if they "stick" to the walls of a tacky vein or artery.)

If the LDL sticks to the wall of the veins for instance, just as anything might stick to the vein, then if it oxidizes and inflames, you've got the beginning of cardio problems, including strokes as well as the blokage itself which would impact the heart. A stroke is a piece of plaque broken off a formation of the same and getting to the brain.

The point I'm making on your issue of cholesterol is:

Take ubiquinol to help neutralize the oxidizing effect because the ubiquitol "rides" on the LDL to get to its cellular destination. So, says Mercola, ubiquitol has the unique ability to stop a particular kind of oxidization...that of "stuck" LDL. And again, ANY nutrient, oil, sugar .... anything can oxidize and inflame...the essence of cardio problems. But as you fortify with the ubiquitol don't forget the Vitamin E (natural not synthetic). The E is your underlying heart protector.

Replied by Mike 62
(Denver, Colorado)

Dave: Half the time you are interesting and half the time you are interested and all the time you are an open minded intellectual. Were everybody like you the world would be a better place to live.

Cross-linked proteins accumulate, the turnover of proteins decrease, the synthesis of proteins is impaired, and the oxidation of fat, results in less carbon dioxide being produced, thereby creating the conditions for high rates of ages formation. Energy production diminishes due to the accumulative damages incured to mitochondria protein complexes. Carbon dioxide is a protective factor that prevents the above mentioned processes from occuring. The amount of carbon dioxide produced to the amount of oxygen consumed is the resiratory quotient. Sugar respiration produces the highest RQ. The stress metabolism, in stark contrast, wastes carbon dioxide. Fructose generates more heat and produces more carbon dioxide than starch, protecting glycation labile amino acids and lipids, staving off the initial step in ages formation.

Replied by Dave
(Fountain Inn, Sc)

Greetings Mike 62 from Denver,

Well, next to "Ted" you are the best technical guru we have on EC...I love to read your explantion of interactions and relationships. So your compliments are expecially valued since they come from you.

Your latest post discusses relationships between carbon dioxide reduction and the "AGES" formation, for instance. That carbon dioxide is a key issue is confusing to me and I've wondered about that especially in light of the good that nitric oxide is supposed to do for us. And just as that inter relationship is confusing to me so also is the relationship between H2O2; supposedly good for us but if we have lots of extra oxygen then isn't that a set up for extra oxidation?

I believe I know what all the nutrients/molecules that you mention do ... sort of...but how they inter relate is still maze-like to me. Just recently I've been re studying how the heart works...the kind of thing we all studied in basic biology. I just keep on being amazed; four valves? Really? And the right side sends the blue blood to the lungs and it comes back into the left atrium bright red laden with oxygen to ultimately be released by other values just in precise rhythm, some opening while some are closing and then the arteries take the blood to the upper body including brain and some to the lower body, trunk and legs, and it all goes non stop, without rest, 24/7 for up to 120 years or so (possibly), about 5, 000 beats an hour, and well over 100, 000 beats in a full day all run by an electrical system...but no batteries are needed. And the veins that return the blood to the magic pump are so different from the arteries. That pump is unlike all other muscles in the body and my little study is just the surface of the intricies going on. There are little devices on the valves that keep them in the shape they need to be, for instance.

Just a month ago I dedicated myself to studying the lympth system. Mercy. That too is so very complicated. I'd refer anyone interested to just Wikipedia the lymph system and be ready to "be amazed." The more I study, the more I realize that we are "fearfully and wonderfully made."

Back to your last post. I read and re read and think I followed your interactions. The carbon dioxide as I said is still throwing me. So please be patient with my non technical mind and help me understand how CO2 helps the body...because its DECREASE is a crucial factor in "AGES" creation...right? And how Hydrogen Peroxide is not a super oxidizer...and how nitric oxide inter relates in the metabolic process. Looking forward to being educated.

Your student,


Replied by Mike 62
(Denver, Colorado)

Dave: You always stretch the intellect, thinking of clues and angles, becoming an enlightened knowledgable wise man. Dissolved mainly as bicarbonate, carbon dioxide has a myriad of functions, mainly by way of forming carboxylated adducts with other macro molecules. As with other enzymes that employ biotin as a cofactor, pyruvate carboxylase uses carbon dioxide as a substrate to activate oxaloacetate. The enzyme catalyzing the first step of fats, acetyl CoA, uses carbon dioxide to form malonyl CoA. The formation of malonyl CoA inhibits fatty acid oxidation, promotes glucose oxidation, and insulin sensitivity. Blood clotting proteins, for their activity, require carboxylation of their glutamate residues. Fructose increases carbon dioxide by raising energy generating metabolism, more so than starch, oils, or proteins. Fructose activates the enzyme complex PDH. Fructose reduces the levels of the proinflammatory peptide leptin. Fructose keeps the voltage-gated calcium channels open, required for the secretion of insulin containing granules from B-cells of the pancreatic islets. Fructose, compared to glucose, decreases insulin 4:1 and lowers blood fatty acid concentrations. Fructose levels in the blood rarely rise more than 1% even after ingesting high doses. Fructose is converted to glucose, glycogen, lactate, and carbon dioxide.

Replied by Dave
(Fountain Inn, Sc)

To Mike 62,

On your response re the essential uses by the body of carbon dixoide...

first I'm really interested in your analysis of fructose.

Unless I misunderstand you, it is your understanding that fructose (as in refined fructose or as in fructose from eating fruits?) ...I assume you mean in the form of the refined sources, say out of sucrose which is 50 percent fructose, which is why you say refined fructose is less glycemic active than glucose? And you mention a number of other positives of fructose (again I'm assumeing fructose as in right out of a coke?). Because I've read lots of authorities, just recently Mercola who blast refined sugar, esp high fructose corn syrup and just refined fructose...He nearly calls fructose in refined for a poison.

So, I must be mistaken somewhere. I defer to you at all times on these tech points. But help me follow the fructose analysis.

And then I have a few questions about carbon dixoide and enzyme functioning which is one of the many things you explain that carbon dixoide accomplishes in the system.

Thanks for your scholarship.


Replied by Mike 62
(Denver, Colorado)


There is overwhelming observational evidence that sugar from fruit, nectar, and cane, through the mechanism of fructose, increases the the respitory quotient more than starch, oil, or protein. Butterflys that migrate from Canada to Mexico get all their fuel from the sugar in nectar. So do the hummingbirds that fly across the Carribean. An 80/10/10er who weighs 120 lbs. and runs 6 miles daily gets all her fuel from the 10lbs. of fruit she eats. The east africans have the 20 best times in the marathon. They get most of their fuel from corn gruel. Corn has way more fructose than other grains. Raw sugar is way better than cooked starches.

Increased Energy

1 User Review
5 star (1) 

Posted by Honest Man (United Kingdom) on 08/01/2023

I saw a GP on a television program talking about how COq10 i great for your heart and increases energy levels so I thought I would give it a try.

Definite improvement in energy levels without bouncing off the ceiling, sustained improvement, but it must be the ubiquinol version for better absorption. Like everything else, not overnight improvement but after a couple of weeks, and if its also benefiting my heart, all the better.