P5P: Uses and Health Benefits of Bioavailable Vitamin B-6

on Jul 20, 2021| Modified on Jul 26, 2021
Deep Sleep, Trigger Thumb
Posted by Deirdre (CT) on 07/20/2021

I started using P5P a couple of weeks ago for a trigger thumb that got aggravated again 8 months after a cortisone shot from frequently lifting and carrying one of my elderly dogs. P5P supposedly takes up to 6 months to work so slow going, but I definitely have more flexibility and less clicking in the thumb joint within 30 minutes of taking it, which lasts a few hours. Also appears to somewhat improve my cold hands and feet.

The main thing I noticed is that when 2 PHP capsules are taken with magnesium l threonate after dinner, it really zonks me out for the night. It has a deeply calming effect, which has been reported by other people too. Anyone with sleeping issues should try this P5P with Magnesium and see if it helps.

Lichen Planus
Posted by Mspatpat (Dayton, Ohio) on 06/28/2011

I have had skin Lichen Planus for about 1-1yrs. I tried all the Dr's suggestion. But it always returned just as bad. Finally and herbalist for a health food store in Atlanta Georgia call (i think) the Garden of Eden, told me to take 2000-3000mg of L-Lysine & 50mg P5P (B6) 3x per day.

And from the first 1000 mg that evening my itching & breakouts decrease about 99%!! I like the L-Lysine by Solaray that also contains vitamin C, Zinc and Vitamin B6. Hope this helps.

Posted by Penelope (Boston, Ma) on 10/24/2009

The most incredible supplements I have ever tried for acne are L-Glutathione (500 milligrams up to 3 times a day) and vitamin B6 (ONLY get the P5P form. The other form can cause neuropathy). Split a 50 milligram pill of vitamin B6 (P5P) up and take a few times a day. I would ask your doctor about going up to as high as 100 milligrams of P5P if you really need that much to keep your skin clear. My skin is completely clear as long as I take the B6 or the L-Glutathione. I do not need to take both of these supplements together to have clear skin, - both have worked separately equally as well to clear my skin in record time (about a week to see results) but test it out and see what works for you - both have amazing health benefits. I have noticed that L-Glutathione has the added benefit of also making my hair really shiny and healthy looking.

Both vitamin B6 and L-Glutathione are potent detoxifiers of the liver so go up to the dose you need VERY slowly! If you break out initially, bear with it - this is just a detox/cleansing reaction.

Try opening a capsule of vitamin B6 (P5P) and take a third of it - or half of it - and see how you do Same goes with the L-Glutathione pills or powder . You can take the same dosage up to 3 times a day. Definitely take the B6 with food because it can make you nauseous. Also, the B6 (P5P) could keep you up by giving you energy if you take it late at night.

Topically, Jojoba oil is great for acne. It moisturizes without clogging pores. I wear it all over my face and neck at night. It is the only moisturizer that does not break me out!

I have suffered with severe cystic acne and was on 3 courses of Accutane so I know what it's like to suffer with acne. With either of these supplements, thankfully I don't have to suffer anymore. I hope this info helps anyone out there who is struggling with acne.

Posted by Tim (Perth, Western Australia) on 03/13/2009

I am a 46 year old male who has suffered from regular bouts of depression for most of my adult life. These depressed episodes were not usually linked to any situational cause and indeed could be very difficult to understand for my family because there was no obvious trigger or reason why I was depressed. The symptoms presented as physical as well as mental and I would suffer from joint pain, lethargy and extreme nausea and in severe bouts even cold sweats and shivering that would last for days and sometimes a week. I have tried prescription anti-depressants but the side effects were almost as bad as the ailment so I resolved to put up with the ups and downs (I only probably had episodes bad enough to take off work maybe twice a year).

About 2 years ago someone put me on to 5 Hydroxy Tryptophan or 5-HTP as a precursor to serotonin production and I decided to give it a try (the potential for weight loss was an added incentive) and I found the results somewhat hit and miss until after some research and experimentation I hit on the combination of 5-HTP (100mg) combined with Pyridoxal 5 Phosphate (15mg) (the active enzyme version of vitamin B6 and assists in the conversion of the 5-HTP to serotonin) taken first thing in the morning on an empty stomach (I avoid eating for at least half an hour). The theory from my research into taking it on an empty stomach is that this avoids the 5-htp metabolising into serotonin in the stomach before it can be absorbed into the bloodstream. Further, I have found that the active version of B6 is more effective than the common variety version (pyridoxine) because I think I struggle to metabolise the pyridoxine variety into the active enzyme and therefore have a natural B6 deficiency (probably why I don't produce enough serotonin).

I haven't had a bout of depression for over 12 months now despite the fact that I have experienced (as many others have over the past 4 months) the most stressful and extreme anxiety creating environment of my professional life.

Apart from sharing my discovery on this excellent website I have a question about Apple Cider Vinegar and my 5-HTP regimen. I have in the past week begun to experiment with the ACV and Baking Soda remedy for Acid Reflux and I have a dilemma in that the majority of posts suggest that the ACV/BS solution should be taken on an empty stomach. If I take it first thing in the morning at the same time as the 5-HTP and B6 combo will that cause the 5-HTP to metabolise into serotonin in my stomach before it gets a chance to be absorbed (My research indicates that serotonin itself can't be absorbed). Because I don't want to jeopardise the efficacy of the depression remedy, I am waiting half an hour to drink the ACV concoction which is inconvenient to say the least as it makes me nauseas and I can't eat breakfast before having to leave for work (maybe that is the weight loss trick).

Any suggestions? By the way the ACV/BS Combo seems to be working with some interesting side effects (nausea diarrhoea and gas) but it's still too early to tell.

Cradle Cap
Posted by Dee (Australia) on 07/18/2015

B6 for Cradle cap:

Most cradle's cap is due to a deficiency of Vitamin B6 and magnesium (B6 needs magnesium to be absorbed).

*Take B6. A nursing mother should take 30mg of P5P (P5P is the best form of B6, it is active B6) supplement each day for at least a month, plus 250 milligrams of magnesium.

Topical B6 for Cradle cap.

This works very very well.

*Apply a vit-b6 salve or cream to head 2x daily for 2 to 3 days.

Topical B6 recipe:

Things You'll Need

  • Vitamin P5P (B6) capsules (or tablets)
  • 1/4 cup olive oil
  • Mortar and pestle (*if using tablets.)
  • Measuring cup


1. Using P5P capsules is best because there is less fillers in the capsules than the tablets. If using tablets, Mortar and pestle. Crush two or three Vitamin B6 tablets with a mortar and pestle until very fine.

2. Measure 1/4 cup vegetable oil and pour into a clean bowl. Add crushed B6 tablets and mix well.

3. Apply mixture to baby's scalp two times daily. The cradle cap should clear up in two days.

Trigger Finger
Posted by Mimi (San Diego ) on 06/10/2019

Hello. I had trigger finger really bad a year ago. Tried everything on this site. Did not work. I did more research and Pyridoxal 5 Phosphate (P5P) WORKS....gone gone! I took 3 a day for 7 months and GONE. I still take 1 a day and I have absolutely no stiffness. Get it at a health food store. May help arthritus.

Trigger Finger
Posted by Niecie (Covina, CA) on 05/21/2020

Trigger finger seems to be a vitamin B6 deficiency. My mom had a severe case for years. She could not bend her finger and had pain. I began giving her vitamin B6 in P-5-P (pyridoxal-5-phosphate) form. 50 mg 3x/day. Within a few weeks all pain was gone and she had full movement. I then reduced her dose to 50mg twice a day and still no symptoms. Truly a miracle! This remedy is also good for carpal tunnel syndrome.