Melatonin Lotion
Health Benefits

Melatonin Lotion for Pain Relief: Recipe + Success Stories

on Nov 13, 2023| Modified on Sep 30, 2025
The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.
New Research
Posted by Art (California) on 08/31/2025 2684 posts
★★★★★

Here is a brand new study (August 31, 2025) adding further confirmation to the idea that melatonin not only helps attenuate intervertebral disc degeneration, but it can help improve mitochondrial biogenesis and help with the repair process as discussed here :

https://link.springer.com/article/10.1007/s00018-025-05877-5

Here is an important quote from the link :

' This study demonstrated that AOPP triggered oxidative stress, exacerbated mitochondrial injury, and increased NP cell apoptosis. Additionally, melatonin enhanced mitochondrial function and protected NP cells from oxidative injury. Further studies demonstrated that melatonin enhanced mitochondrial biogenesis and modulated mitochondrial dynamics and mitophagy via the Peroxisome proliferator-activated receptorγcoactivator 1α (PGC-1α) signaling pathway, maintaining mitochondrial homeostasis and thereby decreasing excessive apoptosis and extracellular matrix (ECM) degradation. A PGC-1α inhibitor lessened melatonin's effect on the mitochondrial quality system, weakening its protective function in NP cells against oxidative stress. Furthermore, in vivo experiments confirmed that melatonin slowed the progression of IVDD. These findings provide a theoretical basis for treating IVDD by targeting mitochondrial dysfunction and modulating the mitochondrial quality control system. Melatonin could be an effective treatment for IVDD. '

These effects suggest that melatonin lotion (ML) may have synergy with the Hyaluronic Acid / Stopain remedy for degenerative disc disease (DDD) as discussed here :

https://www.earthclinic.com/cures/ddd-art-solbrig.html

Art


New Research
Posted by Art (California) on 02/13/2024 2684 posts
★★★★★

A new study came out today that shows that in spinal injuries above T8, normal melatonin secretion is negatively affected to various degrees. This suggests that melatonin lotion may be a useful tool in directly helping to restore this diminished melatonin secretion for use by the spine. Here is a link to the abstract of that study :

https://pubmed.ncbi.nlm.nih.gov/38347109/

Here is a relevant quote from the study :

' Comparing retained vs abolished secretion, only 23% (4/17) of patients with a lesion above T8 retained melatonin secretion, compared to 80% (4/5) with a lesion below T8 (p = 0.022). '

Art