★★★★★
https://link.springer.com/article/10.1007/s00018-025-05877-5
Here is an important quote from the link :
' This study demonstrated that AOPP triggered oxidative stress, exacerbated mitochondrial injury, and increased NP cell apoptosis. Additionally, melatonin enhanced mitochondrial function and protected NP cells from oxidative injury. Further studies demonstrated that melatonin enhanced mitochondrial biogenesis and modulated mitochondrial dynamics and mitophagy via the Peroxisome proliferator-activated receptorγcoactivator 1α (PGC-1α) signaling pathway, maintaining mitochondrial homeostasis and thereby decreasing excessive apoptosis and extracellular matrix (ECM) degradation. A PGC-1α inhibitor lessened melatonin's effect on the mitochondrial quality system, weakening its protective function in NP cells against oxidative stress. Furthermore, in vivo experiments confirmed that melatonin slowed the progression of IVDD. These findings provide a theoretical basis for treating IVDD by targeting mitochondrial dysfunction and modulating the mitochondrial quality control system. Melatonin could be an effective treatment for IVDD. '
These effects suggest that melatonin lotion (ML) may have synergy with the Hyaluronic Acid / Stopain remedy for degenerative disc disease (DDD) as discussed here :
https://www.earthclinic.com/cures/ddd-art-solbrig.html
Art
New Research
★★★★★
https://pubmed.ncbi.nlm.nih.gov/38347109/
Here is a relevant quote from the study :
' Comparing retained vs abolished secretion, only 23% (4/17) of patients with a lesion above T8 retained melatonin secretion, compared to 80% (4/5) with a lesion below T8 (p = 0.022). '
Art
