Our city limits require a rabies vaccination or else you get a nasty-gram from the Humane Society. Three strikes and you can no longer own pets. Anyway, that being said, I get a rabies titer every year for my dachshund. He has chronic pancreatitis and the rabies titer is allowed in lieu of a current vaccination.
Because of bad vaccination experiences, I had rabies titers done on my adopted 8-year-old Border Collie mix in place of the shot. Her titers count was much higher than the law requires, I'm sure because of having a shot (unnecessary) every year before I adopted her. Doing titers is very expensive but it's worth it to me to save my dog. Because of the high titer count, Animal Control no longer requires that my dog have an annual shot to get her license.