Enzymes, EGCG
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How to stop the body from generating malformed prions, how to remove them after they have been accumulated in the body and how to remove Amyloid plaques?
In the context of diseases like Amyloidosis or Fatal insomnia
I use enzymes and EGCG but this is not enough for me (It do help but maybe only 30%)
Thank you.
Hi James,
Human studies are lacking for both, but colloidal silver nanoparticles (AgNPs) may be helpful for Amyloidosis.
Art
Prion Disease Feedback
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Prion diseases are rare, fatal, neurodegenerative disorders/brain disorders caused by misfolded proteins that damage the brain, with Creutzfeldt-Jakob disease (CJD) being the most common form in humans; always progress to death within months to years after symptoms begin.
Causation: beef infected with Bovine Spongiform Encephalopathy (Mad Cow Disease), infected tissues during surgeries or transplants and other.
Prions and amyloid proteins are not the same, but prions are a specific type of amyloid protein that can cause infectious diseases by inducing misfolding by binding to normal proteins of the same type and forcing them into an abnormal, disease-causing shape that resists breakdown, leading to toxic clumps in the brain. While amyloids can form in various organs and are linked to several diseases, prions specifically affect the brain and are associated with neurodegenerative disorder; they can also impact other organs. Prions do not contain DNA or RNA.
Infectious: Yes, prions can transmit their misfolded shape to normal proteins, causing disease. No, amyloids are not infectious; they are aggregates that can cause disease but do not propagate. Prions: They are a subclass of amyloids all prions are amyloids, not all amyloids are prions
Internet search questions for further reading.
prions and amyloid proteins the same, phytochemicals that show prion-inhibiting activity, antiprion herbs/phytochemicals
Prion diseases include Creutzfeldt-Jakob disease (CJD), variant CJD, kuru, and Gerstmann-Sträussler-Scheinker disease. Amyloid proteins are associated with neurodegenerative diseases such as Alzheimer's disease, Parkinson's disease, and Huntington's disease.
Saliva tests are more effective than urine tests for detecting prions. I would think frequent testing would be required; for their are still unknowns about dosages for anti-prion phytochemicals.
Across diverse assays, particularly strong anti-prion phenolics include anthocyanins (Oenin, Myrtillin), chlorogenic/neochlorogenic acids, carnosic acid/carnosol, ellagic acid, pentagalloylglucose, EGCG and related catechol-type flavonoids, rosmarinic acid, myricetin, and punicalagin. Some show multi-step effects (blocking conversion, disaggregating fibrils, and reducing PrP^Sc in cells), but there is no single standardized potency ranking yet, and most data remain preclinical. Skullcap American and Chinese.
This is one disease you “DO NOT” want to treat yourself. Seek out Naturopathic Doctor, Functional Medicine Doctor or similar.
Amyloidosis coming in Part ll How to heal!
(USA)
06/15/2026
Prion Disease Part II Amyloidosis in prion diseases, amyloidosis is characterized by the accumulation of fibrils, which are aggregates of misfolded proteins. These fibrils can cluster together to form plaques, which occur in various neurodegenerative conditions. Medicinal herbs with anti-amyloid, anti-aggregative, or anti-fibrillation effects in the brain *Bacopa monnieri, Garlic, EGCG (Matcha has highest EGCg) luteolin, myricetin, silibinin. *Plaques turmeric/curcumin, Ginkgo, Salvia, Ashwagandha. *Curcumin from turmeric and rosemary, which contains carnosic acid, have shown potential in decreasing amyloid plaques and improving cognitive function. *Curcumin (from turmeric) and cinnamon have shown potential in reducing brain plaques and have shown neuroprotective properties. Internet search: medicinal herbs with anti-amyloid, anti-aggregative, or anti-fibrillation effects in the brain. Acetylcholinesterase inhibitors (AChEIs) are chemicals that block the enzyme acetylcholinesterase, preventing it from breaking down the neurotransmitter acetylcholine. In prion diseases, acetylcholine levels can drop significantly. This reduction is linked to the brain damage caused by the accumulation of misfolded proteins. Carnosic Acid and Carnosol: These compounds from rosemary have shown antioxidant and neuroprotective effects, found to have antiprion properties in prion disease contexts. Rosemary contains compounds that may inhibit the breakdown of acetylcholine along with other herbs. Internet search for more info: Carnosic Acid and Carnosol in Rosemary and Prion Disease Acetylcholine is a neurotransmitter essential for memory formation. Internet search: does acetylcholine levels drop in prions diseases. Tumeric, EGCg, Skullcap (American/Chinese) and Rosemary are all antiprion herbs. This is just my opinion with no science backing. If one would take smaller does of each. Tumeric with Bioperine 250 mg 3 times daily, EGCg 250 mg 2-3 times daily, Skullcap 250 mg of each American and Chinese 2-3 times daily and Rosemary 250 mg 2-3 times daily. All with a carrier herb like Ginger 100 to 200 mg. This would be spread though out the day taken every 2-3 hours. For example you buy both kinds of Skullcap get blank vege capsules and make your own dosage of 250 mg of each Skullcap and 100mg of Ginger and the same for the rest of herbs listed. Prions are resilient and need constant inhibitors. This would be a discussion with your Naturopathic Doctor. Have saliva test every 3-4 weeks to check prion levels to see if changes need to be made in regimen. Vitamin A through Zinc are imperative to have at functioning levels. Some may need to be taken at higher levels. ex. Vit. E, D3, Omega 3's and Choline (Sunflower Lecithin) more. Having nutrient levels checked would be essential. Antioxidants should be taken in a variety. Glutathione: deficiency in Prions Vitamin C, Vitamin E,, Coenzyme Q10, Alpha-lipoic acid, Resveratrol, and Quercetin and more on website: https://wellintruth.com/a-list-of-antioxidants/ Prion cells are not seen as a foreign body to activate immune response. Prions do cause inflammation which activates histamine. Quercetin with Bromelain lowers histamine and acts as antioxidant. Oxidative stress contributes to cell death in prion diseases by promoting iron-dependent ferroptosis. Ferroptosis can be inhibited by lipophilic radical trapping antioxidants such as ferrostatin-1, liproxstatin-1, and vitamin E, as well as by iron chelators like desferrioxamine (DFO). These inhibitors help prevent lipid peroxidation, which is crucial in the ferroptosis process. Prevent lipid peroxidation, a damaging reaction that can lead to cell death and various diseases. Lipophilic Antioxidants: Vitamin E, Carotenoids Metal Chelation: Managing metal ion levels will reduce oxidative stress, as metals like Iron, Copper, Manganese can exacerbate oxidative damage. Gut health is very important, brain/gut axis, kill off bacteria and parasites along with the biofilm they create, repair gut lining and feed it pre and pro-biotics. Treat as (leaky gut syndrome). Https://www.harvestheal.com/protocols/anti-prion-diet Findings are found in animal studies and should be discussed with Naturopathic Doctor or similar. Do Not try to treat yourself. Prions are tenacious, replicating Proteins.
