It's important that every woman do research before using any hormones, even progesterone cream (which is toted as natural). All hormones have the potential for side effects. With progesterone, the effects are cumulative since it is fat soluble. So it gets stored in tissues. Even if taking it seems fine initially, over time it may create negative side effects and disrupt your adrenal hormones, DHEA and testosterone levels. It can cause all sorts of mood swings, facial hair, weight gain, etc. If you are considering, make sure you see a doc that practices functional medicine or a naturpath who knows how to balance properly. Best to test and treat your adrenal issues first as progesterone may not be needed once corrected.