Empty Sella Syndrome
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Natural Remedies for Empty Sella Syndrome

| Modified on Sep 23, 2025
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Empty Sella Syndrome (ESS) is a condition where the pituitary gland appears flattened or small on imaging because the sella turcica (a bony cavity at the brain’s base) fills with cerebrospinal fluid. For some, it causes no issues. For others, it may lead to hormonal imbalances, headaches, or vision problems. While medical care is essential, many seek natural, supportive remedies to improve overall health and quality of life.

Quick Facts

  • ESS is often found incidentally on brain scans.
  • Some people remain symptom-free; others experience hormone or vision changes.
  • Natural approaches can support endocrine and nervous system health but should complement—not replace—medical supervision.

Diet and Nutritional Support

  • Whole-food diet: Emphasize fruits, vegetables, lean proteins, and healthy fats to support hormone balance.
  • Reduce inflammatory foods: Limiting sugar, refined carbs, and processed foods may help reduce headaches and fatigue.
  • Hydration: Adequate water intake supports cerebrospinal fluid balance and brain health.

Herbs and Nutritional Supplements

While evidence is limited, some supplements may support endocrine and nervous system function:

  • Adaptogenic herbs (ashwagandha, rhodiola, holy basil) — may help the body manage stress and support adrenal balance.
  • Vitamin D and magnesium — important for bone, nerve, and hormone health.
  • B-complex vitamins — support energy production and pituitary-adrenal function.
  • Omega-3 fatty acids — anti-inflammatory support for brain and vascular health.

⚠️ Always consult a healthcare provider before taking supplements, especially if you have confirmed hormone deficiencies or are on medication.

Lifestyle Approaches

  • Stress reduction: Meditation, yoga, or breathing exercises may help balance the hypothalamic-pituitary-adrenal (HPA) axis.
  • Regular exercise: Gentle aerobic and resistance training supports circulation, mood, and energy.
  • Sleep hygiene: Consistent, restorative sleep is critical for hormonal regulation.
  • Headache management: Natural aids like peppermint oil, hydration, or acupressure may offer relief.

Conclusion

Empty Sella Syndrome often requires monitoring by an endocrinologist or neurologist, but natural remedies can provide supportive care. Focusing on diet, supplements, lifestyle changes, and stress reduction may help improve well-being and manage symptoms safely.

Keep reading below to see which natural remedies have helped our readers find relief from this condition, and share your own experiences!

The comments below reflect the personal experiences and opinions of readers and do not represent medical advice or the views of this website. The information shared has not been evaluated by the FDA and is not intended to diagnose, treat, or prevent any disease or health condition. Always consult a qualified healthcare professional for medical concerns.
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Empty Sella Syndrome Remedies

Posted by Jackie (South Carolina) on 09/23/2025

Hello, I would like to know the best advice to treat empty sella syndrome and post long concussion syndrome and is therapy is the only way to treat extreme conditions.

Replied by Art
(California)
09/23/2025
2679 posts

Hi Jackie,

You didn't say in what you wrote if the concussion('s) was the cause of the Empty Sella Syndrome (ESS)? I ask because sometimes the cause of ESS is unknown or idiopathic.

The long post concussion syndrome (LPCS) can be considered a milder to moderate form of traumatic brain injury (TBI). You didn't mention any specific symptoms, so I can't address that, just speak in very general terms about it.

I can't tell you what to use, but I can tell you what I would use for myself if I had a form of TBI. I would use supplements that can cross the blood brain barrier (BBB), have potent anti inflammatory properties to try and counter neuroinflammation, potent anti oxidative stress effects and if possible, have anti apoptotic and mitochondrial protective effects. The intent being to potentially afford brain reparative and protective effects through multiple methods of action simultaneously. I would also give consideration to the idea that this particular group of supplements are likely to offer other potential health benefits not related to TBI.

Seven supplements that could show at least some of those benefits are :

1. Melatonin - At higher dose or to tolerance if very sensitive to melatonin, which I am not sensitive at all.

2. NAC - At 1200 mg/day in two divided doses of 600 mg at breakfast and 600 mg at dinner. A dose that has been used in multiple human studies.

3. Omega 3s - especially DHA and to a lesser extent, EPA at higher dose levels used in human studies in the area of 3 to 4 grams per day.

4. Magnesium - In a form that can effectively cross the BBB such as Magnesium L Threonate or Magnesium Taurate at the RDA for elemental magnesium For the magnesium l threonate form this could be in the 2 gram to 2.5 gram range per day depending on the manufacturer.

5. Astaxanthin - At higher dose of 24 mg/day. A dose that has previously been used in human studies.

6. Vitamin D - At a high enough dose to bring your 25 OH d level up to at least 60 to 70 ng/ml, a level that is considered high by doctors, but not too high. Lab testing will be required to reach this range.

7. CoQ10 / Ubiquinol - At 400 mg per day, a dose that has been used in human studies effectively.

I am only pointing out what I would do for myself if I had a form of TBI. If you are considering any of the above supplements, you will have to get your doctors approval and supervision before doing so, to be safe and to make sure they are compatible with any medications you are taking.

Art


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