I am very interested in this Niacin issue. I find that a 250 mg dose of Niacin will keep me warm in very cold weather. so If I am going to go out int 5 degree Fahrenheit weather, then a dose of Niacin will work. I know this works. So now the question arises whether dissolving the Niacin in the DMSO would work even better? I am off to the lab to check this out. If I don't come back, please don't send flowers.