I take ALA for blood sugar (prediabetes) and it helps, but I get side effects if I take too much. ALA binds to certain heavy metals, like mercury, which makes it one of the top supplements to chelate heavy metals. But lower dosages are safest if you have heavy metal poisoning. I open a 150 mg capsule and pour 1/3 (approx 50 mg )into a small amount of water and drink it. If I don't have any symptoms (headaches), I take another 1/3rd capsule 6-8 hours later. Very effective supplement for prediabetes.