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Non alcoholic fatty Liver Disease (NAFLD) is now called metabolic dysfunction-associated steatotic liver disease (MASLD). No matter what you call it, this new study (August 18,2025) suggests that because new insights have been found regarding how MASLD goes about its business and progresses, the known methods of action of melatonin may make it a potential remedy option as discussed here :
https://www.biomolther.org/journal/view.html?uid=1658&vmd=Full
Here is a relevant quote from the literature link :
' Currently, there is an absence of efficacious therapeutic options available for the management of MASLD. Consequently, an in-depth exploration of the roles of free fatty acids (FFAs) and ferroptosis in the progression of MASLD may reveal hitherto unidentified therapeutic targets. In the study, we established an early lesion model of MASLD, namely NAFL, and comprehensive analyses of lipid metabolism, hepatocellular injury, iron homeostasis, and ferroptosis were performed. The HFD and FFAs treatment significantly elevated the expression of enzymes associated with lipid synthesis, including ACC1 and FASN, leading to enhanced lipid accumulation in hepatocytes. Additionally, HFD and FFAs resulted in increased iron loading and a reduction in the levels of the antioxidant enzyme GPX4, which ultimately triggers ferroptosis. In contrast, the administration of melatonin effectively inhibited the activity of lipid synthesis-related enzymes, decreased hepatic lipid deposition, alleviated free fatty acid-induced iron dysregulation, and mitigated liver damage. Mechanistically, melatonin has been shown to attenuate hepatocytes ferroptosis by modulating the KEAP1/NRF2/HO-1 pathway, which in turn diminishes free fatty acids-induced oxidative stress. In conclusion, melatonin alleviates MASLD progression by curbing FFAs-induced oxidative stress and ferroptosis. These findings provide valuable insights into the mechanisms underlying MASLD progression and highlight melatonin as a potential therapeutic agent for the management of MASLD. '
MASLD, previously known as NAFLD is a common and growing health problem in humans that the medical community does not have a direct and effective treatment for so the importance of finding out that melatonin may be a potential remedy for MASLD is of significant importance!
Melatonin continues to show itself as a very highly useful and multifaceted molecule for human health, animal health and plant life health!
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