My adrenals were determined to be low from a saliva test after my alternative MD believed my fatigue was due to adrenal depletion. Results of the test were that he was correct. I had been under severe stress for years and the effect was lack of energy which no amount of vitamins, herbs etc could seem to help. My MD put me on dessicated addrenal glandulars, two with each meal.
In a month I was feeling my energy level totally return. Maintance was two a day as directed by another alternative MD (many years later).
Also in the first saliva test, my testosterone levels were also low so small "drops" were prescribed. That level also improved. With the two: adrenal supplementation and testosterone supplementation, I'm in great shape in terms of energy level, now into my mid 60s.