Low Dose Naltrexone (LDN) for MS (Multiple Sclerosis)

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(1) 
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Susan D. (MI) on 11/20/2023:
5 out of 5 stars

I concur w/U! I saw a chart a # of yrs ago noting mgs best for each autoimmune disorder. MS 3.5 mg//more is not best or necessary. Sue

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Susan D. (MI) on 11/20/2023:
5 out of 5 stars

LDN for my celiac helps great deal. I had read + saw a chart showing 3.5 mg max for MS patients helps majority MS prescribers best. May want to check that info. πŸ¦ƒπŸ‡ΊπŸ‡ΈβœοΈ

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Shell17 (Victoria, Australia) on 12/27/2022:
5 out of 5 stars

My experience with LDN... after being diagnosed with MS in 2018 (symptoms of neuropathy, fatigue, bladder problems, lack of balance, gait problems). I was put on Tysabri and had no improvement in symptoms. I developed a brain tumor in 2020 and had that removed - whether it was that drug, nobody knows.

I subsequently went on LDN in 2021 and this year (2022) the tests from my neurologist showed that I have improvements in all of my nerve tests and no new symptoms. Of course he tries to sell me new pharmaceuticals at every visit but I say no and continue with the LDN.

It must be filled at a compounding pharmacy and it costs $105 for 100 capsules in Victoria, Australia - I take 1 x 5mg tablet daily.

I found this website helpful - https://ldnresearchtrust.org/what-is-low-dose-naltrexone-ldn

It may not be a cure, but I have experienced zero side effects and the regular MS drugs have a massive list of side issues.

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Jb (Tx) on 08/06/2018:
5 out of 5 stars

When taking LDN, you work up from a dosage of 2 mg to 4.5 mg. If you feel dizzy, nauseous, or get headaches at 4.5mg, try taking your dosage back down to 3 or 3.5mg. You've arrived at your correct dosage when you feel good again. Very small people or those with poor liver function can't handle 4.5mg. Many people do well on 3mg.

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Rsw (Oh) on 02/17/2017:
5 out of 5 stars

Hi Heather,

I have been taking LDN for more than six years for autoimmune problems. When you take the LDN, it will block your opiates and opiate receptors for four to six hours, which may be why you experience an increase in pain after taking it. It is during the next 18 a 20 hours that LDN will make your body think it is in short supply of these, and it will make more of both. This is usually where the healing is found, especially with MS. If you take LDN more than once in any 24 hours, the blockade will begin again and interrupt the healing time. May I suggest you try taking 3 mg. LDN once a day, and see how it goes? You could then experiment with 4.5 mg. once a day, but if you experience any muscle cramping at 4.5 mg, which sometimes happens at this dose with MS, then go back to 3 mg once a day. I hope you have joined the Yahoo LDN Group with over 13,000 members who take LDN, about half for MS. They can give you their personal experiences and guide you with what has worked out best. Wishing you relief from your pain soon. Best wishes!

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Deb (Florida ) on 03/24/2016:
0 out of 5 stars

LDN must be prescribed by a MD & comes from a compounding pharmacy. Around $20 a month. I think you should start low to see how you react 1 to 1.5 mg, then 3 mg, then 4.5 mg if it doesn't bother you. It makes me VERY dizzy, then nauseous. Good luck!

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Rsw (Oh) on 03/24/2016:
5 out of 5 stars

Hi Hristanad,

LDN is an inexpensive prescription drug in the US. It is gaining recognition among doctors and many will prescribe it. If, however, you can't get a prescription, you can buy it overseas, online. There are also several doctors in the US who will prescribe after a phone consultation. You can buy 50mg pills that can be diluted with 50ml of distilled water to make your own solution, where 1ml of solution equals 1mg of LDN. Measure the dose with a $1,5ml dropper, available at any drug store. Very easy to do. It will keep in your refrigerator for up to 90 days. The new updated, comprehensive book, "The LDN Book" by Linda Elsegood is available on Amazon. If you join the LDN Yahoo Group and ask how to get some, the members will give you details about where you can buy it. I'm not sure that I can post it here. If you look on the www.ldninfo.org site, it will give you a list of reliable compounders in the US to use if you get a prescription and the Yahoo LDN Group address. My doctor told me LDN would be very helpful for my autoimmune problems, and to try to get some because she wouldn't prescribe it off-label. I buy mine overseas for the past six years and have never had any problems, and about half of the 12,000 members also buy their own. I think you can google "buy LDN" and you will see some sights, but most buy from the one run by Ian, who also takes it himself and donates to the LDN community. It does not come from China. If you have any further questions, please join the Yahoo Group that is listed on the LDN site listed in this post, and you will be welcomed and your questions will be thoughtfully answered. By the way, for the Crohn's people here, there are several posts right now from experiences of member users, about the current research and Dudley(the moderator) has posted links to first-hand accounts from other Crohn's users, and many links to research and helpful information. LDN is completely non-toxic, taken by mouth, with no side effects except possible short lived sleep problems, and that can be remedied by taking it in the morning. It is helpful with many autoimmune diseases, including Crohn's, IBS, Hashimotos, RA, (many others listed on the LDN site)by modulating the immune system, not killing it, is extremely helpful for MS, and mitigates the damage to healthy cells in cancer treatment. Some have successfully used it with other supplements and/or allopathic or holistic treatments for cancer. Best wishes! You have nothing to lose and much to gain.

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Serena (Clover Sc) on 02/17/2014:
5 out of 5 stars

This is to Ga_bass from Atlanta, Ga 05/01/2013 concerning friend that was diagnosed with MS. Please tell her to research low dose Naltrexone. It has stopped MS symptoms for many. Good luck and stay away from artificial sweeteners.
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Fred (South Africa) on 05/17/2013:
4 out of 5 stars

My wife was diagnosed with MS seven years ago. The Neurologist started treatment with Rebiff and ocasionally she had to go to hospital to receive a cortisone drip. She had constant headaces, fever and spasms after the injection. She was only allowed to use Panado as a pain killer. (Sometimes up to 8 every day) As time progressed and relapses ocurred the spasms headaces and body pains worsened to such an extent that she could barely walk. Speech and bladder controll was also severely affected. She was introduced to LDN little more than a year ago. We started with a daily dose of 2mg after 9 pm, and she is now on 4. 5mg per day. She has no more headaches, never had a spasm again and can walk short distances without any aid. Her speech and bladder controll also improved. Although the MS caused a lot of damage the LDN improved her quality of life to a great extent. Pity we did not know about LDN sooner
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Dudley (Virginia Beach, Va) on 12/15/2009:
5 out of 5 stars

Naltrexone is a cheap generic pharmaceutical approved by the U.S. Food and Drug Administration for treating drug and alcohol addiction. In very low doses, it is proving to be remarkably effective in treating multiple sclerosis--with minimal side effects and at a price anyone can afford.

For more information about Low Dose Naltrexone (LDN), visit

http://tinyurl.com/intro-to-ldn

The above site features links to LDN-related research, case histories, discussion groups, books, articles, and video clips.

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