Mast Cell Activation Syndrome (MCAS) is a condition in which mast cells release excessive histamine and other inflammatory chemicals, leading to a variety of symptoms such as hives, flushing, digestive issues, headaches, and anaphylaxis-like reactions.

While medical treatments often include antihistamines and mast cell stabilizers, many individuals find relief through natural remedies that support histamine metabolism, reduce inflammation, and stabilize mast cells.

Symptoms of MCAS

• Chronic hives or skin rashes
• Flushing and redness
• Swelling (edema)
• Itchy skin or eyes
• Gastrointestinal issues (bloating, diarrhea, acid reflux)
• Food and chemical sensitivities
• Frequent headaches or migraines
• Shortness of breath or wheezing
• Brain fog and anxiety

Top 7 Natural Remedies for MCAS

Managing MCAS naturally involves reducing histamine levels, stabilizing mast cells, and supporting the immune system. Below are the best natural strategies for relief.

1. Low-Histamine Diet

One of the most effective ways to manage MCAS is by following a low-histamine diet. This involves avoiding foods that trigger mast cell degranulation and increasing foods that help stabilize mast cells.

Foods to Avoid:

• Fermented foods (kimchi, sauerkraut, kombucha)
• Aged cheeses
• Processed meats (salami, bacon, sausage)
• Alcohol (especially red wine and beer)
• Tomatoes, spinach, eggplant, and avocados
• Citrus fruits (oranges, lemons, limes)

Foods to Eat:

• Fresh meats and poultry
• Leafy greens (except spinach)
• Quercetin-rich foods (onions, apples, berries)
• Ginger and turmeric
• Coconut and olive oil
• Low-histamine herbs (basil, oregano, thyme)

2. Quercetin

Quercetin is a powerful flavonoid that acts as a natural mast cell stabilizer. It prevents the release of histamine and reduces inflammation.

How to Use: Take 500-1,000 mg of quercetin twice daily, preferably with food.

3. Vitamin C

Vitamin C is a natural antihistamine and supports the immune system.

How to Use: Take 1,000-2,000 mg of vitamin C per day.

4. DAO Enzyme Supplement

Diamine Oxidase (DAO) is the enzyme responsible for breaking down histamine in the gut. A DAO supplement can be beneficial for those with MCAS and histamine intolerance.

How to Use: Take DAO before meals to help break down dietary histamine.

5. Probiotics for MCAS

Not all probiotics are beneficial for MCAS. Some probiotic strains produce histamine, while others help degrade it.

Best Probiotics for MCAS:

• Bifidobacterium infantis
• Bifidobacterium longum
• Lactobacillus rhamnosus

6. Omega-3 Fatty Acids

Omega-3 fatty acids (found in fish oil and flaxseed oil) reduce inflammation and may help stabilize mast cells.

How to Use: Take 2,000-3,000 mg of omega-3s daily.

7. Stress Management

Stress triggers mast cell degranulation, leading to histamine release. Managing stress is crucial for controlling MCAS symptoms.

Effective Stress Reduction Techniques:

• Meditation and deep breathing
• Yoga and gentle stretching
• Regular exercise (walking, swimming)
• Adequate sleep (7-9 hours per night)