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Heloise (Detroit, Michigan) on 01/29/2012
H. pylori expresses the highest level of urease seen in bacteria. The urease activity was recognized as an important parameter enabling acid survival early on in reasearch on the gastric mechanisma of H. Pylori. (Modlin I. M. , Sachs G. Acid related diseases: biology and treatment. Philadelphia: Lippincott Williams & Wilkins; 2004. P. 467)
Urea is a major end product of nitrogen metabolism by mammals. Diffusing from the blood through mucosal tissues and into the gastrointestinal tract. [... ] By metabolozing urea, H. Pylori is naturally acid resistant. [... ] When urea is added to H. Pylori cell suspensions at low pH values (down to 2. 0), bacterial survival is enhanced 10^3 - 10^6-fold compared with that in suspensions without urea, and survival is associated with rapid alkalinization of the suspensions by urease. (Brodgen, K. A. , Roth, J. A. , Stanton, T. B. , e. A. Virulence mechanisms of bacterial pathogens. Washington, D. C. : ASM Press; 2000. P. 69)
Conclusion of a study by W. H. Wang e. A. (doi:10.1136/gut.52.4.490): Aspirin inhibited the growth of H pylori, suppressed the mutagenic effect of metronidazole, and enhanced the susceptibility of H pylori to antimicrobial agents.
Be careful with the dosage: A study by E. S. Huang e. A. (doi:10.1016/j.amjmed.2010.12.022) concludes: Regular aspirin use is associated with gastrointestinal bleeding. Risk seems more strongly related to dose than duration of aspirin use. Efforts to minimize adverse effects of aspirin therapy should emphasize using the lowest effective dose among both short- and long-term users.
We showed that H. Pylori can be eradicated from human gastric xenografts after short-term administration of sulforaphane at a dose (1. 33 mg/day in each xenograft [volume, %u223C7 ml]; 0. 19 mg/ml) that can be achieved in the human diet (100 mg/day [stomach volume, 0. 5 to 1 liter]; 0. 1 to 0. 2 mg/liter). Thus, the administration of sulforaphane that can be safely delivered in the diet, particularly from broccoli sprouts, could be beneficial for the treatment of H. pylori-associated gastric diseases.
Herbal or naturalistic treatment of ulcers includes the use of cayenne pepper and licorice root, among other things. Since the population of Thailand has little or no Hpylori-caused stomach ulcers, this has lead to the belief that eating cayenne pepper is an effective H-pylori preventive. Thai children begin eating small amounts of cayenne pepper when very young and increase their intake as they age. Some studies say cayenne kills the bacteria and stimulates mucous lining development in the stomach and intestine."
The double-blind, randomized placebo-controlled trial study by Lian Zang e. A. (DOI: 10.1111/j.1523-5378.2005.00301.x) into the efficacy of cranberry juice on Helicobacter pylori infection concluded:
Regular consumption of cranberry juice can suppress H. pylori infection in endemically afflicted populations.
A study by Paolo Ruggiero e. A. "To investigate whether red wine and green tea could exert anti-H pylori or anti-VacA (VacA is a pore-forming toxin produced by H. Pylori) activity in vivo in a mouse model of experimental infection" (ISSN 1007-9327 CN 14-1219/R):
Red wine and green tea are able to prevent H pylori-induced gastric epithelium damage, possibly involving VacA inhibition. This observation supports the possible relevance of diet on the pathological outcome of H pylori infection.
Conclusion of a double-blind, placebo-controlled, randomized clinical trial by B. May e. A. (DOI: 10.1046/j.1365-2036.2003.01522.x) "to assess the efficacy and safety of enteric coated capsules containing a fixed combination of 90 mg peppermint oil and 50 mg caraway oil (PCC; Enteroplant) in patients with functional dyspepsia.":
These results demonstrate the good tolerability and the favourable risk-benefit ratio of PCC for the treatment of functional dyspepsia. And another study by B. May concludes "In our trial, however, H. pylori-positive patients given PCC showed a substantially better treatment response, and there were no interpretable differences in treatment outcome between the two sub-groups given placebo."
Try to incorporate as many of available treatments as you can into your daily diet to improve the long-term outcome of H. pylori infection.
When I feel my stomach burning or stinging in the night I take vitamin C to increase acidity which seems to stop the pain by killing the bacterium. I also take aspirin which might improve the susceptibility to various treatments. Cranberry juice, red wine, peppermint- and liquorice tea also seem to improve the treatment.
