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Art (California) on 08/15/2025
I suggested that she drink two bottles of D-Mannose water each week, spread as evenly apart as possible and that should help prevent most if not all of her monthly UTIs. I suggested drinking one bottle on Sunday morning and one bottle on Wednesday afternoon.
I told her to just take a 500 ml bottle of filtered water and add 1 1/2 teaspoons of D-Mannose powder to each bottle and shake well until dissolved and to drink two of these bottles each week. She started as soon as her D-Mannose package of bulk powder arrived.
It has been over two years since she started this regimen, so I asked her the other day how it was working out for her. She looked at me and smiled and pointed to a bag of D-Mannose powder on her counter and said she hasn't had a UTI since she started drinking it twice a week and I smiled back!
D-Mannose is said to bind to E coli. which is the most common bacteria to cause UTIs at about 80% to 90%, but her doctor had previously told her that her UTIs were caused not just by E coli., but other bacteria on occasion. So perhaps D- Mannose can bind to the others as well?
I just don't understand why doctors don't even consider something like D-Mannose, that has a good safety profile, as a preventative or treatment instead of prescribing potent antibiotics that can cause other health problems. She didn't mention having any problems with taking D-Mannose twice a week.
Art
Nick (London, UK) on 12/23/2024
Art (California) on 08/16/2020
The active component against UTIs in cranberry/cranberry juice is D-Mannose, a common supplement. D-Mannose is much more potent and works by binding to the E.coli bacteria preventing the bacteria from sticking to the urinary tract surfaces and bladder interior surface, allowing the bacteria to be safely flushed away when urinating, preventing the infection from spreading or continuing to exist. Because of this method of action, bacterial resistance to D-Mannose does not occur because D-Mannose is not attacking the virus, but rather just binding to it. This can become a major problem with antibiotics which the bacteria become resistant to.
Another issue with antibiotics is that they tend to destroy the gut bacteria both good and bad and this can contribute to more UTIs in the long run if good gut bacteria is destroyed that would normally keep E.coli controlled. Here is a link to a study where they show that D-Mannose can be used as a preventative for frequent UTIs in women who are prone to these infections, but my experience is that it is also effective in men, but women get significantly more UTIs than men :
https://pubmed.ncbi.nlm.nih.gov/32597599/
Many people who have frequent UTIs develop bacterial resistance and then stronger and stronger antibiotics are needed to try and fight the UTI, but these more potent antibiotics can bring a myriad of side effects that nobody wants or needs! For example, one highly potent antibiotic that can be used for UTIs is Ciprofloxacin / Cipro and this particular antibiotic has the well known side effect of causing torn tendons and ligaments and blown achilles tendons (OUCH!). I wrote about this serious issue in another EC post and explained how to help repair some of this ligament and tendon damage.
D-Mannose is thought to be effective only against E.coli based UTIs which means it will not likely work for all UTIs, but it will work for the majority because E.coli is the most common cause of UTIs at approximately as high as 90% of cases.
D-Mannose can also be used as a preventative against UTIs when traveling to help prevent a UTI from getting started in the first place. Here is a link to typical D-Mannose supplements and powder :
https://www.amazon.com/s?k=D-mannose&ref=nb_sb_noss_2
All you need to do is mix the powder with water and drink it down or take the capsules, all per label directions.
Two other simple preventatives is to void as soon as the urge is felt so that the urine does not sit in the bladder longer than it has to in an environment that can be conducive to bacterial growth. The second preventative is the use of probiotics such as L. rhamnosus, L. reuteri and L. casei shirota.
Art
Deb C. (East Coast, Usa) on 11/24/2016
After a while, the drugs and doctors visits were overwhelming. I found out of D-mannose on this site. It is a wonder! Now when I feel a UTI coming on, I take a couple doses of D-Mannose for a day or two and it is gone. I has changed my life for the better.
Sabrina (Houston) on 08/03/2016
Carl (London) on 06/21/2016
Gg (Denver) on 03/02/2016
Julie (Nm) on 12/02/2015
Rebecca M. (Co) on 09/02/2015
D-mannose was a game changer for me after years of recurrent UTIs!
Linda (Florida) on 04/25/2015
1st, they are caused from bacteria getting up into the urethra( the pee pee tube). When you have sex, always pee before and after because during sex, the bacteria get pushed up there.when you pee after, it pushes out the bacteria. A natural sugar found in Cranberries is called D-Mannose powder. Available at all health food stores.
If you have a UTI, take1 teaspoon every few hours for a day. Within 30-45 minutes of the first dose, the pain and fevers will be gone, and the burning. It is a miracle supplement! . It works by making the urethra walls slippery and so the bacteria can't hold on. It's so much easier and healthier than antibiotics. I take it an hour before I know I'm going to have sex with my boyfriend. Works to keep you free of urinary tract infections. Just look it up on the Internet to learn more about it. I like the powder better than the pills. The powder works faster!