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B (Munich) on 12/25/2022: 
Michele (TX) on 05/09/2021:
Cheryl (Philadelphia ) on 05/06/2017:
Trisha (Columbus, Indiana) on 07/22/2016:
Kelly (Seattle) on 06/07/2016:
In response to Cat from Nevada's post in the arthritis section regarding anxiety and heart palpitations from MSM
I began after using the MSM gel for my arthritic knees and thumb. I experienced almost immediately within 2 days better movement and no pain in my knee, hip and thumb. On the 4th day I even walked a mile with my grandchildren which I was unable to do since April of 2014. My allergies were gone, and so was brain fog, I felt fantastic and could move around and be normal but? I began experiencing heart palpitations on day 5 and felt quite uneasy. They continued until I became frightened. I wrestled with feeling fabulous or heart problems as I do not like feeling disabled at 56, but have discontinued the product. This morning my walking is worsened, the pain is coming and my allergies are terrible. So extremely sad. I was taking 1/8 teaspoon once a day and had increased to 1/4 2 times a day. Any ideas?
According to the 'inventor' of MSM, Dr. Stanley Jacobs, MSM is a "cholinesterase inhibitor. Cholinsterase is an enzyme that stops excessive passage of nerve impulses from one nerve cell to another."
So if this cholinesterase enzyme is INHIBITED by MSM, then one may develop worsening anxiety, muscle twitching, cramping, and yes, heart palpitations, etc., -- all the symptoms of excess choline or acetylcholine.
I found this out the hard way, experiencing worsening leg cramps, muscle twitching and anxiety.
It may help some who have very low levels of choline, but should be avoided by others.
Om (Hope, Bc, Canada) on 06/03/2013:
I wonder if this supplement works on the lower chakras as I have had experience with herbs and even homeopathics causing effects that, lets say, were not "wholesome" and in effect were psychedelic experiences. I believe these supplements work differently on the individual, as in old and established medicine systems it is imperative to know ones Doshas, otherwise healing can be mere guess work.
I don't like unwelcome mental experiences so I stay away from a product if this happens. Om
Kathy (Covington, Virginia) on 11/26/2010:
Tom (Regina, Sk) on 11/26/2010: 
Also, remember it takes days at least even once stopped taking any RX drug for it to be really well cleared out by the liver and kidneys. So even if one goes off the drug in order to take MSM, it is best to wait several days at least before starting MSM. (one can lessen this down to non-existent by simply slowly increasing the daily MSM dosage, a week at a time, starting at the lowest dose for body weight and then after a month or two getting up to the highest). BTW, the antidepressant RX drugs have what must be the highest placebo effect of any drug class, at least for 'depression'(placebo effect for this drug class on other prescribed conditions like OCD, anxiety, etc. not given):www.newsweek.com/2010/01/28/the-depressing-news-about-antidepressants.html
It seems I am not alone in having moral qualms about blowing the whistle on antidepressants. That first analysis, in 1998, examined 38 manufacturer-sponsored studies involving just over 3,000 depressed patients. The authors, psychology researchers Irving Kirsch and Guy Sapirstein of the University of Connecticut, saw as everyone else had that patients did improve, often substantially, on SSRIs, tricyclics, and even MAO inhibitors, a class of antidepressants that dates from the 1950s. This improvement, demonstrated in scores of clinical trials, is the basis for the ubiquitous claim that antidepressants work. But when Kirsch compared the improvement in patients taking the drugs with the improvement in those taking dummy pills clinical trials typically compare an experimental drug with a placebo he saw that the difference was minuscule. Patients on a placebo improved about 75 percent as much as those on drugs. Put another way, three quarters of the benefit from antidepressants seems to be a placebo effect. Remember this is NEWSWEEK talking, THE Establishment mass news outlet, so for them to put it out there means it's already long obvious to most.
Did you read over the ANXIETY section?:
https://www.earthclinic.com/cures/anxiety.html
If anything, there's too many things there you can try! So pick one that's cheap, easily available, and has some YAYS behind it.
Denise (Brooklyn, New York) on 08/10/2008:
Sherry (Jacksonville, North Carolina) on 11/27/2007:
Warning
I am so grateful to God for this forum. I can totally relate to DL from CA, that posting is almost a total duplicate of what I just recently experienced. I had been having constant pain in my legs and feet for over a year and had, had my fill. I did some research and came across the MSM. I was also diagnosed with osteopenia about the same time, so I decided to try it.
Two night ago I had my son take me to the ER, I was having a lot of what's been described here concerning the heart beating weird, anxiety(I guess) because I don't know how else to explain how I was feeling, shallow breathing, heaviness of chest etc. All this had been going on for some time and I normally could meditate on scriptures and it would go away, this night was different. My jaunt to the ER, showed irregular heartbeat, palpitations to be exact. However, all of my blood work came back normal, showing no previous heart attacks or heart disease. I have been referred for a stress test. I am going to discontinue my use of MSM and see what happens. I will keep you posted as to what happens after I am no longer taking this product. Oh yeah, one of the other effects is headaches. I also started getting headaches that wouldn't go away. I sorta fluffed that off figuring it was a sinus thing, however, these aren't sinus area specific. So, I'm thinking this is all related. Time will tell.
I am very happy for those folks that this works for. Of course, everybody's metabolism is different, so what works for others may not work for someone else. Anyone else that may have related info. that would be helpful to my situation please feel free to e-mail me. God Bless
