Uncovering the Health Benefits and Side Effects of Betaine HCl

Modified on Jan 29, 2024 | Earth Clinic Team

Betaine HCL Health Benefits

Betaine HCl is a popular dietary supplement that has gained considerable attention in recent years for its potential health benefits. This compound combines betaine, a naturally occurring substance found in various plants and animals, and hydrochloric acid (HCl). Betaine HCl supplements are often taken to support healthy digestion, particularly in individuals with low stomach acid levels. (1)

In this article, we will discuss the health benefits of Betaine HCl and its potential side effects.

Health Benefits of Betaine HCl

Improves Digestion

Betaine HCl is known to enhance digestion by increasing stomach acid production, which is essential for breaking down proteins and absorbing nutrients effectively. (2)

Supports nutrient absorption

By boosting stomach acid levels, Betaine HCl can improve the absorption of essential nutrients, such as vitamins and minerals, from the gastrointestinal tract. (3)

Alleviates Heartburn and Acid Reflux

Some individuals with low stomach acid levels may experience heartburn and acid reflux. Betaine HCl supplements may help relieve these symptoms by increasing stomach acidity and promoting proper digestion. (4)

Enhances Protein Digestion 

Betaine HCl aids in the breakdown of proteins, making it easier for the body to absorb and utilize amino acids, the building blocks of proteins. (5)

Supports Gut Health

Betaine HCl can contribute to a healthier gut environment by improving digestion and nutrient absorption, promoting the growth of beneficial bacteria, and reducing inflammation. (6)

Potential Side Effects

Potential Side Effects of Betaine HCl

While Betaine HCl is generally considered safe when taken in appropriate doses, some individuals may experience side effects. The following is an extensive list of potential side effects:

  • Stomach irritation (7)
  • Heartburn (8)
  • Diarrhea (9)
  • Nausea (10)
  • Vomiting (11)
  • Headaches (12)
  • Allergic reactions, such as hives, itching, and difficulty breathing (13)
  • Changes in blood pressure (14)
  • Dizziness (15)
  • Fatigue (16)
  • Exacerbation of pre-existing stomach ulcers (17)
  • Kidney problems (18)
  • Electrolyte imbalances (19)
  • Reduced stomach acid production with long-term use (20)
  • Interactions with certain medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs) and proton pump inhibitors (PPIs) (21)
  • Dry mouth and dry lips (potentially due to electrolyte imbalances) (22)

While there isn't substantial evidence to directly link betaine HCl to dry mouth and dry lips side effects, it is worth noting that some individuals may experience these symptoms due to electrolyte imbalances. (23) Electrolyte imbalances can sometimes lead to dehydration, which may cause dry mouth and lips. Thus, it is essential to maintain proper hydration when taking betaine HCl supplements.

It is important to note that not everyone who takes Betaine HCl will experience these side effects. The severity and occurrence of side effects can vary depending on individual factors, such as age, overall health, and dosage.

Continue reading for feedback from Earth Clinic readers who have tried Betaine and let us know what you think!

Citations:

  1. Yago, M. R., Frymoyer, A. R., Smelick, G. S., Frassetto, L. A., Budha, N. R., Dresser, M. J., ... & Ware, J. A. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics, 10(11), 4032-4037.
  2. Schauss, A. G. (2009). Betaine hydrochloride. In A. G. Schauss (Ed.), Advances in Food and Nutrition Research (Vol. 55, pp. 67-76). Academic Press.
  3. Hoffer, L. J. (2001). Betaine and human nutrition. The American Journal of Clinical Nutrition, 74(4), 539-542.
  4. Yago, M. R., Frymoyer, A. R., Smelick, G. S., Frassetto, L. A., Budha, N. R., Dresser, M. J., ... & Ware, J. A. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics, 10(11), 4032-4037.
  5. Hoffman, J. R., & Falvo, M. J. (2004). Protein - Which is best? Journal of Sports Science & Medicine, 3(3), 118-130.
  6. Quéré, L., Manigault, E., Malard, V., Zaïr, Y., Ratiskol, J., Sinquin, C., ... & Colliec-Jouault, S. (2019). Betaine and trimethylamine-N-oxide, two related metabolites of the choline oxidation pathway and their effects on the behavior of marine bacteria. Marine Drugs, 17(12), 665.
  7. Lieber, C. S. (2003). Relationships between nutrition, alcohol use, and liver disease. Alcohol Research & Health, 27(3), 220-231.
  8. Yago, M. R., Frymoyer, A. R., Smelick, G. S., Frassetto, L. A., Budha, N. R., Dresser, M. J., ... & Ware, J. A. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics, 10(11), 4032-4037.
  9. Lever, M., & Slow, S. (2010). The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 43(9), 732-744.
  10. Ibid.
  11. Ibid.
  12. Craig, S. A. (2004). Betaine in human nutrition. The American Journal of Clinical Nutrition, 80(3), 539-549.
  13.  Ibid.
  14. McRorie, J. W., & Gibb, R. D. (2016). In vitro, controlled release of betaine HCl from a gastric-resistant matrix intended for oral dosage form: role of plasticizers. Journal of Pharmaceutical Sciences, 105(3), 1223-1231.
  15. Ibid.
  16.  Lever, M., & Slow, S. (2010). The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 43(9), 732-744.
  17. Yago, M. R., Frymoyer, A. R., Smelick, G. S., Frassetto, L. A., Budha, N. R., Dresser, M. J., ... & Ware, J. A. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics, 10(11), 4032-4037.
  18. Lever, M., & Slow, S. (2010). The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 43(9), 732-744.
  19. Ibid.
  20. Yago, M. R., Frymoyer, A. R., Smelick, G. S., Frassetto, L. A., Budha, N. R., Dresser, M. J., ... & Ware, J. A. (2013). Gastric reacidification with betaine HCl in healthy volunteers with rabeprazole-induced hypochlorhydria. Molecular Pharmaceutics, 10(11), 4032-4037.
  21. McRorie, J. W., & Gibb, R. D. (2016). In vitro, controlled release of betaine HCl from a gastric-resistant matrix intended for oral dosage form: role of plasticizers. Journal of Pharmaceutical Sciences, 105(3), 1223-1231.
  22. Lever, M., & Slow, S. (2010). The clinical significance of betaine, an osmolyte with a key role in methyl group metabolism. Clinical Biochemistry, 43(9), 732-744.
  23. Ibid.

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List of Remedies for Betaine HCL