Art (California) on 04/16/2025

https://www.sciencedirect.com/science/article/abs/pii/S0040816625001648?via=ihub

Here are relevant quotes from the study :

Highlights

• HG inhibits the AMPK/SIRT1 pathway in endothelial cells.
• Mel activates the AMPK/SIRT1 pathway.
• Mel upregulates HIF-1α expression by activating the AMPK/SIRT1 pathway.
• Mel improves endothelial cell angiogenesis and mitochondrial function via AMPK/SIRT1/HIF-1α pathway to promote wound healing.

The study lays a theoretical foundation for a deeper understanding of the mechanism of Mel to improve diabetic wound healing.

Melatonin Gel may be a potential way to apply melatonin for this purpose. Directions how to make melatonin gel here :

https://www.earthclinic.com/supplements/melatonin-gel.html

Art