Sam-E for Depression

5 star (4) 
1 star (1) 

Mary (Arcadia, Ca) on 04/07/2014:
1 out of 5 stars


I bought Sam-e for the depression I have had for so 30 years. I got a little headache from it and then I became dizzy. I thought because it was working on my brain already. I read the ingredients and was surprised to see it had Tosylate disulfate. Which is connected to sulpha or sulphur.

I am very allergic to Sulpha drugs and about a half hour later I started to itch. I called the pharmacist where I live and explained to her what it had. She said it would only have a minute amount in it but to get benadryl if I had any side effects. I started to feel needle like picks all over my body and took care of it with the benadryl. Maybe it won't happen to you but be careful.


Karen (Ephrata, Wa - Washington) on 12/24/2012:
5 out of 5 stars

Just a word on Sam-e, it is amazing stuff. It has helped me more than any other supplement. I would like to share some information about it though. It should never be taken with any other substance that effects seratonin, such as rhodiola, 5-htp or even dextromethorphan wich is in Robotussin D.M. and many over the counter medications. And of course Prozac and other prescription medications. For me Sam-e has worked far better than anything else.

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Angel (Crawfordville, Florida) on 09/22/2008:
5 out of 5 stars

I have suffered from mild depression for about 10 years and on. As healthcare is very expensive, I never got meds from the doctor, I could not afford them. I was doing some research for natural depression cures, and came across SAM-e. With in 36 hours I felt like a new person.

I took it for 2 weeks, and noticed a that I felt "normal". I read that the reason that SAM-e works so well and most people take it and then stop for a while, is because SAM-e is one of the few meds that cross the blood-brain barrier, thus making it more effective.

After taking it for two weeks, I stopped taking it for over a month as I did not need it. Then I found this site last night while searching for a cure for a friends yeast infection, and came across Apple Cider Vinegar.

I had some here, and took it last night and WOW. I am so not a morning person, but I jumped out of bed and have felt like a million bucks all day long. I will now be taking the ACV daily as well!

Sharon (Boston, MA) on 02/04/2007:
5 out of 5 stars

My husband had a habit of waking up at 2:00am in terrible anxiety every night. The rest of the night was toss and turn, toss and turn. I started him on SamE and overnight, the pattern ceased. Now he loves it and takes it every night. No more insomnia, no more anxiety, no more depression. Good stuff!!

Shelly (Sioux City) on 03/01/2004:
5 out of 5 stars

In the fall when the time changes, I often have a very difficult time with anxiety and depression, especially as the holiday season approaches. After being on Effexor for a couple of years, I decided I needed to find a natural solution as I was tired of always feeling 2 steps behind. I experimented with the supplement SAM-e and discovered that it worked wonders fairly quickly. I also realized that some brands are better than others as it is a very unstable molecule. I took the lower dosage 2x a day for about a month. At that point I had to stop taking it for a while because it appeared that my brain chemistry had corrected itself and I no longer needed supplementation. Now I take it as needed, which is about 1 pill every few months. I hope others coming off the anti-anxiety medication will give this supplement a try. It was a wonderful discovery! By the way, doctors in Europe prescribe this remedy more often than prescription meds.
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