Sam-E for Depression

5 star (4) 
  80%
1 star (1) 
  20%

Mary (Arcadia, Ca) on 04/07/2014:
1 out of 5 stars

Warning

I bought Sam-e for the depression I have had for so 30 years. I got a little headache from it and then I became dizzy. I thought because it was working on my brain already. I read the ingredients and was surprised to see it had Tosylate disulfate. Which is connected to sulpha or sulphur.

I am very allergic to Sulpha drugs and about a half hour later I started to itch. I called the pharmacist where I live and explained to her what it had. She said it would only have a minute amount in it but to get benadryl if I had any side effects. I started to feel needle like picks all over my body and took care of it with the benadryl. Maybe it won't happen to you but be careful.

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Karen (Ephrata, Wa - Washington) on 12/24/2012:
5 out of 5 stars

Just a word on Sam-e, it is amazing stuff. It has helped me more than any other supplement. I would like to share some information about it though. It should never be taken with any other substance that effects seratonin, such as rhodiola, 5-htp or even dextromethorphan wich is in Robotussin D.M. and many over the counter medications. And of course Prozac and other prescription medications. For me Sam-e has worked far better than anything else.

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Angel (Crawfordville, Florida) on 09/22/2008:
5 out of 5 stars

I have suffered from mild depression for about 10 years now..off and on. As healthcare is very expensive, I never got meds from the doctor, I could not afford them. I was doing some research for natural depression cures, and came across SAM-e. With in 36 hours I felt like a new person.

I took it for 2 weeks, and noticed a that I felt "normal". I read that the reason that SAM-e works so well and most people take it and then stop for a while, is because SAM-e is one of the few meds that cross the blood-brain barrier, thus making it more effective.

After taking it for two weeks, I stopped taking it for over a month as I did not need it. Then I found this site last night while searching for a cure for a friends yeast infection, and came across Apple Cider Vinegar.

I had some here, and took it last night and WOW. I am so not a morning person, but I jumped out of bed and have felt like a million bucks all day long. I will now be taking the ACV daily as well!
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Sharon (Boston, MA) on 02/04/2007:
5 out of 5 stars

My husband had a habit of waking up at 2:00am in terrible anxiety every night. The rest of the night was toss and turn, toss and turn. I started him on SamE and overnight, the pattern ceased. Now he loves it and takes it every night. No more insomnia, no more anxiety, no more depression. Good stuff!!
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Shelly (Sioux City) on 03/01/2004:
5 out of 5 stars

In the fall when the time changes, I often have a very difficult time with anxiety and depression, especially as the holiday season approaches. After being on Effexor for a couple of years, I decided I needed to find a natural solution as I was tired of always feeling 2 steps behind. I experimented with the supplement SAM-e and discovered that it worked wonders fairly quickly. I also realized that some brands are better than others as it is a very unstable molecule. I took the lower dosage 2x a day for about a month. At that point I had to stop taking it for a while because it appeared that my brain chemistry had corrected itself and I no longer needed supplementation. Now I take it as needed, which is about 1 pill every few months. I hope others coming off the anti-anxiety medication will give this supplement a try. It was a wonderful discovery! By the way, doctors in Europe prescribe this remedy more often than prescription meds.
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