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Angel (Crawfordville, Florida) on 09/22/2008
5 out of 5 stars

I have suffered from mild depression for about 10 years now..off and on. As healthcare is very expensive, I never got meds from the doctor, I could not afford them. I was doing some research for natural depression cures, and came across SAM-e. With in 36 hours I felt like a new person.

I took it for 2 weeks, and noticed a that I felt "normal". I read that the reason that SAM-e works so well and most people take it and then stop for a while, is because SAM-e is one of the few meds that cross the blood-brain barrier, thus making it more effective.

After taking it for two weeks, I stopped taking it for over a month as I did not need it. Then I found this site last night while searching for a cure for a friends yeast infection, and came across Apple Cider Vinegar.

I had some here, and took it last night and WOW. I am so not a morning person, but I jumped out of bed and have felt like a million bucks all day long. I will now be taking the ACV daily as well!

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Replied By Karen (Ephrata, Wa - Washington) on 12/24/2012

Just a word on Sam-e, it is amazing stuff. It has helped me more than any other supplement. I would like to share some information about it though. It should never be taken with any other substance that effects seratonin, such as rhodiola, 5-htp or even dextromethorphan wich is in Robotussin D.M. and many over the counter medications. And of course Prozac and other prescription medications. For me Sam-e has worked far better than anything else.
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Replied By Rob (Manhattan, Ny) on 12/26/2012

Hi Karen..... thanks for your input on SAMe

1. How much do you take?
2. What time do you take it?
3. Do you take it with food or on an empty stomach?

thanks

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Replied By Rob (Manhattan, Ny) on 12/27/2012

I found a good answer to my own post... From Dr. Ray Sahelian:

"I have personally taken SAM-e just to see what it would do, and it is quite a powerful mood lifter. Perhaps I'm sensitive to nutrients, but I notice the effects on 100 mg, sometimes even less. Almost all the tablets on the market are 200 mg. If you plan to take it under medical guidance, here's a few tips your doctor may not know. It's best taken in the morning before or with breakfast. I notice within one to two hours being more alert and more motivated to do things, and in a better mood. Many of the clinical studies have used several hundred mgs but in the long run this can cause side effects. The most common are overstimulation, insomnia, and headache. You can actually feel anxious and restless if you take too much. If you wish to take a small amount, bite off half or a third of a 200 mg tablet and use the rest the next day. You may need to adjust your dose down over the next few days since it can start building up in the system, or you can take a day or two off. Each person is unique in their response."

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Replied By Mum (Qld, Australia) on 12/31/2014

I have suffered severe depression and anxiety for many years. I have been hospitalised for several weeks and attempted suicide multiple times. During my worst anxiety, I was horrible to be around and developed extreme agoraphobia. I managed to get my condition under control using medications and CBT. However the medications had negative side effects including extreme weight gain of 50Kg and sexual difficulties. The meds also made me need to sleep 10 - 11 hrs a night. Several months ago, I bravely stopped medication and moved onto a combination of SAM-e and vitamin B complex. I feel even BETTER than I did on medication and the negative side effects are gone. I am sleeping well and my family have commented how wonderful I look. I am calm and collected. I need to take 400mg of SAM-e daily, as the 200mg dosage isn't strong enough. On 200mg, my anxiety and depression creeps back in slightly. I highly recommend SAM-e. Make sure to take the vitamin B's as well. This makes it work better.
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