Robin (Minneapolis, MN) on 06/06/2009

I have had depression most of my life. Everyone's body chemistry and brain make-up is different and that is why dr's have a hard time finding the right meds for people with emotional problems. Anyway, I have just put up with it all these years as I don't like taking Rx. By accident, in taking some acetyl-l-carnitine, I finally realized I wasn't depressed anymore. Not happy, just not down in the pits for a change.
I think Americans are having to eat such nutrient deficient foods that synthetic supplements can't completely cover as good as Mother Nature can; that whole populations are having subclinical and even clinical deficiencies that are being labeled as 'this or that problem' instead of what it really is!
Anyway, I was taking 500mg/day on empty stomach. Another thing it is good for is the heart. L-carnitine is better, but this other helps some with the pressure on the chest also.
Molly (Madison, USA) on 04/11/2008

One time I purchased a bottle of 5-htp, and after taking one capsule morning & evening, just twice, I threw the bottle away. My reaction to 5-htp was horrific; upon further research I learned that high levels of serotonin are associated with SEVERE ANXIETY. I also read that the spice ginger is a serotonin antagonist, so I have a bottle on hand, just in case I ever feel so anxious ever again.
Then I read somewhere online that there is a set of people whose depression responds to Acetyl L-Carnitine, they said the depression lifted in these people when using 3-4 grams a day, and to take two grams of acetylcarnitine on an empty stomach, first thing in the morning.
This amino acid is the most amazing substance; I've never been able to take more than 2 grams per day - there is such great mental clarity, there is utter inability to be depressed, but there simultaneously is no euphoria - just calm lucid clarity. I've read that it assists the brain in making many different neurotransmitters - so it is not anything, not anything at all like 5-htp which floods the brain with serotonin - which, if you don't need it, might create severe anxiety.