DHEA for Vaginal Atrophy

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(1) 
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Deanna (Michigan, US) on 08/07/2014:
5 out of 5 stars

After much research, incredible stress and absolutely no help from traditional MD gynecologists, I found a compounding pharmacy that makes DHEA 3.25mg suppositories in a solid oil type base. I have used them for 1 year now and they have worked wonders for me! My only complaint is that they can be messy since the oil melts at body temperature and will leak out a little. But that is nothing compared to what I was going through before I used them.

My recent physical and blood tests, with a new doctor, showed great improvement in hormone levels and the pap smear came back showing not as much menopausal cellular changes. Some states require a prescription for the compounded suppositories and some do not. You will have to check in your area with a compounding pharmacy to see what the laws are. There are some compounding pharmacies on line that will ship out of state. There is one in Ohio that I use that is excellent. They ship the suppositories packed in ice packs and I haven't had any problems with that. But I live in the next state over so not an extreme distance away.

I finally found a local Osteophathic woman doctor that has been a true Godsend to me. She also prescribes a compounded progesterone cream based on my blood test. I have gone to MD gynecologists all my adult life will never go to one again. The extent of their knowledge for this condition seem to be to prescribe synthetic estrogen, and if you refuse that, recommend you get counseling and suggest an antidepressant medication. I am in no way a depressed person, I was stressed out from all the anxiety they helped cause me with their attitudes and lack of caring. Good luck and God Bless you all, I know how awful and stressful the symptoms of vaginal atrophy can be.

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Patricia (Denver, Co) on 04/28/2014:
5 out of 5 stars

I had vaginal atrophy so bad sex became out of the question. I tried everything. Even forced myself to use hormone creams they made me feel terrible. They made me feel extremely grouchy. I even tried using progesterone cream vaginally. My husband was supportive, but it still felt painful. I read about using dhea in the suppository. So I tried it. This is what I do. I use the Carlson suppositories and cut them in half and and hollow a little spot out for 1/3 of a 5 mg tablet. I started with a half and it was too strong- I am pretty sensitive. I insert this every other morning. I wish I could do it at night, but the dhea keeps me awake. On the days I do not do this I use 1/2 suppository at night - just helps keep things moisturized. I have been doing this for six months and I am amazed sometimes I do not even need to use a suppository prior to intercourse. I would have never even tried it before. This is the answer for me. I normally don't write about this, but I hope it helps someone.
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Sue (Cambridge, Oh, Guernsey) on 05/07/2013:
5 out of 5 stars

Yes, it is still working for me. I have upped the dosage, so I insert a whole 5mg tablet every other day. It works great. Believe me, I've tryed everything--estriol oil, progesterone oil, various other oils, etc. Much too messy, estriol made me spot. This takes like one second and there is nothing there after it dissolves and it dissolves pretty fast. And it's not bad for the man like estrogens. I've been doing this for a long time and have no side effects.

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James (Denver, Co, USA) on 09/09/2012:
5 out of 5 stars

Me again, with an update. We've gone from theory to experience. My wife has been using the 1 mg E3 vaginal suppositories by Bezwecken (available over the web - just search for them). She used them nightly for 2 weeks, and then tapered off to 2 times a week (last week). Happy to report that the discomfort she felt is almost totally gone. Several months ago it was actually painful for her sometimes to have sex. But last night, she reported that there's only minor tenderness. That's awesome progress. After buying these suppositories over the web, and starting to use them, she decided to meet with a Naturopath to be safe. It was fun to have her prescribe the same thing she was already using. Ideally (or supposedly) we can taper off to 1 a week. Just had to post an update, because it sure helped things.

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James (Denver, Co, Usa) on 07/15/2012:
5 out of 5 stars

So glad I found this thread. My wife's 63, and is experiencing vaginal atrophy to the point that she tells me she experiences irritation or pain everytime we're intimate. Well, just like I was the one to do the progesterone cream research several years ago, now I find myself the researcher yet again.

So I found this study that said 250 or so women used DHEA suppositories intravaginally for 12 weeks and reported that vaginal atrophy symptoms were relieved. They used varying strengths, to see if that mattered. As it turned out, the 3.25 mg DHEA ovule or suppository seemed to have pretty good results. I found a pharmacist that reported some of their customers had success with 3.25mg DHEA vaginal suppositories (or ovules), inserting 1 suppository nightly for 12 weeks, then 2-3 times per week thereafter. Has anyone tried this?

Another study I came across, the participants utilized a vaginal suppository containing hyaluronic acid sodium salt 5 mg, vitamin E acetate 1 mg, and vitamin A palmitate 1 mg. Dosing was a suppository intravaginally every night for 14 nights, then tapering to every other night for 14 nights. Of 150 women, 126 women completed the study in full. The study assessed efficacy of the study medication in the areas of burning, itching, inflammation and irritation. Results showed that any symptom that was reported as severe initially was resolved to either mild or absent at the end of four weeks. Anyone ever heard of this?

My wife's in a very demanding job, and doesn't have time to research this, so I'll be checking back to hear from you as to what works for you, while I continue to research further and report anything new I find.

REPLY   5      

Sue (Cambridge, Oh) on 06/05/2012:
5 out of 5 stars

It seems to work very well. But it hasn't done anything for my night sweats. My DHEA is not micronized and I was worried it would not work, but it works fine. Initially, I was wondering how to do this. I found two sites that have vaginal DHEA suppositories--sounds messy and they were about 2.00 each. Just using a piece of the tablet avoids the mess and the expense.

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Sue (Cambridge, Oh, Guernsey) on 05/31/2012:
5 out of 5 stars

I'm 60 and I have a histroy of fibroids and bioidentical hormone replacement. To make a long story short, I went off all hormones about 1 1/2 years ago (except for progesterone cream). Hot flashes, night sweats, and vaginal atrophy. So I got on vaginal estriol oil, which worked well until about 3 months ago when I started spotting. Went off of it and--vaginal atrophy again with painful sex, but the spotting cleared up right away.

But I have found something. DHEA inserted vaginally. I am well lubricated and it does not hurt to have sex. I bought some DHEA, 5 mg. Then I break the tablet into four pieces with a pill splitter. So I am getting a little over 1mg which is enough vaginally. Also, it does to systemic because my skin is significantly oilier. I have been on this for about six weeks with no spotting (estrogen makes my fibroids grow).

Some people say DHEA converts to estrogen and testosterone. I do not know yet if it is converting to estrogen, but my body will tell me. So with that in mind, it probably would not be good for someone with cancer or who is prone to cancer. I would say to ask your doctor, but doctors generally don't know any more about this sort of thing than a fly knows about computer programming.

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