I've had sciatica since the mid-nineties and tried everything from herbal supplements, acupuncture and chiropractic treatments but the pain remained constant, especially on cold, wet, rainy days. Then I purchased some Magnesium oil and placed some in a roll-on bottle of Vitamin E leaving about 1/3rd Vitamin E in the roll-on. The strategic area that I applied it was upon my tail-bone from 1L to 5L. It took about several weeks and I noticed a 75% reduction in pain. I've been using it daily for 6 months and notice a tremendous difference. Good luck!